Compounds > 3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole

3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole and Precancerous-Conditions

3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole has been researched along with Precancerous-Conditions* in 1 studies

Other Studies

1 other study(ies) available for 3-amino-1-4-dimethyl-5h-pyrido(4-3-b)indole and Precancerous-Conditions

Article	Year
Induction of enzyme-altered islands in rat liver by tryptophan pyrolysis products. Journal of cancer research and clinical oncology, 1979, Volume: 95, Issue:3 Two new gamma-carboline derivatives, 3-amino-1,4-dimethyl-5H pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H pyrido[4,3-b]indole (Trp-P-2), isolated from the pyrolysis products of tryptophan, were found to be potent mutagens. When weanling rats were injected with Trp-P-1 and then given diet containing phenobarbital, they developed enzyme-altered islands in the liver. Since these islands are considered to be formed by immediate progeny of "initiated cells" and cell precursors in hepatocarcinogenesis, Trp-P-1 may well be carcinogenic in rat liver. Topics: Adenosine Triphosphatases; Animals; Carbolines; Hot Temperature; Indoles; Liver; Liver Neoplasms, Experimental; Male; Mutagens; Precancerous Conditions; Rats	1979

Article

Year

Induction of enzyme-altered islands in rat liver by tryptophan pyrolysis products.

Journal of cancer research and clinical oncology, 1979, Volume: 95, Issue:3

Two new gamma-carboline derivatives, 3-amino-1,4-dimethyl-5H pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H pyrido[4,3-b]indole (Trp-P-2), isolated from the pyrolysis products of tryptophan, were found to be potent mutagens. When weanling rats were injected with Trp-P-1 and then given diet containing phenobarbital, they developed enzyme-altered islands in the liver. Since these islands are considered to be formed by immediate progeny of "initiated cells" and cell precursors in hepatocarcinogenesis, Trp-P-1 may well be carcinogenic in rat liver.

Topics: Adenosine Triphosphatases; Animals; Carbolines; Hot Temperature; Indoles; Liver; Liver Neoplasms, Experimental; Male; Mutagens; Precancerous Conditions; Rats

1979