3-7-dimethoxyflavone has been researched along with Disease-Models--Animal* in 1 studies
1 other study(ies) available for 3-7-dimethoxyflavone and Disease-Models--Animal
| Article | Year |
|---|---|
Discovery of 3,7-dimethoxyflavone that inhibits liver fibrosis based on dual mechanisms of antioxidant and inhibitor of activated hepatic stellate cell.
The important pathway toward liver fibrosis is the TGF-β1-induced activation of hepatic stellate cells (HSCs). To discover chemicals to inhibit liver fibrosis, we screened 3000 chemicals using cell array system where human HSCs line LX2 cells are activated with TGF-β1. We discovered 3,7-dimethoxyflavone (3,7-DMF) as a chemical to inhibit TGF-β1-induced activation of HSCs. In the thioacetamide (TAA)-induced mouse liver fibrosis model, 3,7-DMF treatment via intraperitoneal or oral administration prevented liver fibrosis as well as reversed the established fibrosis in the separate experiments. It also reduced liver enzyme elevation, suggesting protective effect on hepatocytes because it has antioxidant effect. Treatment with 3,7-DMF induced antioxidant genes, quenches ROS away, and improved the hepatocyte condition that was impaired by H Topics: Animals; Antioxidants; Disease Models, Animal; Hepatic Stellate Cells; Humans; Hydrogen Peroxide; Liver; Liver Cirrhosis; Mice; Reactive Oxygen Species; Transforming Growth Factor beta1 | 2023 |