3-5-dihydroxy-4--methoxystilbene has been researched along with Breast-Neoplasms* in 1 studies
1 other study(ies) available for 3-5-dihydroxy-4--methoxystilbene and Breast-Neoplasms
| Article | Year |
|---|---|
Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells.
Resveratrol, a natural product with a stilbene structure, exerts profound proapoptotic activity in human cancer cells, by triggering the accumulation of ceramide, a bioactive sphingolipid. We studied the biological effects of seven methoxylated and/or naphthalene-based resveratrol analogues and compared these compounds with resveratrol with the objective to identify an analogue with higher ceramide-mediated proapoptotic activity relative to resveratrol. Here we show that the compound with three hydroxyls and a naphthalene ring is the most effective in triggering apoptosis coupled to the induction of endogenous ceramide in human cancer cells. Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Ceramides; Drug Screening Assays, Antitumor; Female; Humans; Resveratrol; Stilbenes; Structure-Activity Relationship | 2005 |