Compounds > 3-5-bis(benzylidene)-4-piperidone

3-5-bis(benzylidene)-4-piperidone and Neoplasms

3-5-bis(benzylidene)-4-piperidone has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 3-5-bis(benzylidene)-4-piperidone and Neoplasms

Article	Year
Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones. Bioorganic & medicinal chemistry, 2016, 05-15, Volume: 24, Issue:10 A series of 1-acyl-3,5-bis(benzylidene)-4-piperidones 3-7 were designed and synthesized as novel cytotoxic agents. These compounds displayed potent cytotoxic properties towards human Molt4/C8, CEM, HSC-2, HSC-3 and HSC-4 neoplasms and also to murine L1210 cells. The majority of the compounds have sub-micromolar or very low micromolar IC50 and CC50 values and are significantly more potent than the reference alkylating drug melphalan. Evaluation of these compounds against non-malignant HGF and HPLF cells revealed the tumour-specific toxicity. In particular, 3e emerged as a promising lead cytotoxic agent which caused apoptosis and PARP1 cleavage in HSC-2 cells. Topics: Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Mice; Neoplasms; Piperidones; Structure-Activity Relationship	2016

Article

Year

Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones.

Bioorganic & medicinal chemistry, 2016, 05-15, Volume: 24, Issue:10

A series of 1-acyl-3,5-bis(benzylidene)-4-piperidones 3-7 were designed and synthesized as novel cytotoxic agents. These compounds displayed potent cytotoxic properties towards human Molt4/C8, CEM, HSC-2, HSC-3 and HSC-4 neoplasms and also to murine L1210 cells. The majority of the compounds have sub-micromolar or very low micromolar IC50 and CC50 values and are significantly more potent than the reference alkylating drug melphalan. Evaluation of these compounds against non-malignant HGF and HPLF cells revealed the tumour-specific toxicity. In particular, 3e emerged as a promising lead cytotoxic agent which caused apoptosis and PARP1 cleavage in HSC-2 cells.

Topics: Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Mice; Neoplasms; Piperidones; Structure-Activity Relationship

2016