Compounds > 3-5-bis(3-4-5-trimethoxybenzylidene)-1-methylpiperidine-4-one

3-5-bis(3-4-5-trimethoxybenzylidene)-1-methylpiperidine-4-one and Carcinogenesis

3-5-bis(3-4-5-trimethoxybenzylidene)-1-methylpiperidine-4-one has been researched along with Carcinogenesis* in 1 studies

Other Studies

1 other study(ies) available for 3-5-bis(3-4-5-trimethoxybenzylidene)-1-methylpiperidine-4-one and Carcinogenesis

Article	Year
Small-molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer. Cell death & disease, 2017, 09-14, Volume: 8, Issue:9 Triple-negative breast cancer (TNBC) has an aggressive phenotype and a poor prognosis owing to the high propensity for metastatic progression and the absence of specific targeted treatment. Here, we revealed that small-molecule RL71 targeting sarco/endoplasmic reticulum calcium-ATPase 2 (SERCA2) exhibited potent anti-cancer activity on all TNBC cells tested. Apart from apoptosis induction, RL71 triggered excessive autophagic cell death, the main contributor to RL71-induced TNBC cell death. RL71 augmented the release of Ca Topics: Animals; Apoptosis; Autophagy; Calcium Signaling; Carcinogenesis; Cell Line, Tumor; Curcumin; Diarylheptanoids; Endoplasmic Reticulum Stress; Female; Humans; Intracellular Space; Mice, Nude; Mitochondria; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Small Molecule Libraries; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays	2017

Article

Year

Small-molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer.

Cell death & disease, 2017, 09-14, Volume: 8, Issue:9

Triple-negative breast cancer (TNBC) has an aggressive phenotype and a poor prognosis owing to the high propensity for metastatic progression and the absence of specific targeted treatment. Here, we revealed that small-molecule RL71 targeting sarco/endoplasmic reticulum calcium-ATPase 2 (SERCA2) exhibited potent anti-cancer activity on all TNBC cells tested. Apart from apoptosis induction, RL71 triggered excessive autophagic cell death, the main contributor to RL71-induced TNBC cell death. RL71 augmented the release of Ca

Topics: Animals; Apoptosis; Autophagy; Calcium Signaling; Carcinogenesis; Cell Line, Tumor; Curcumin; Diarylheptanoids; Endoplasmic Reticulum Stress; Female; Humans; Intracellular Space; Mice, Nude; Mitochondria; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Small Molecule Libraries; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2017