3-4-oxoisopropylideneshikimic-acid has been researched along with Infarction--Middle-Cerebral-Artery* in 1 studies
1 other study(ies) available for 3-4-oxoisopropylideneshikimic-acid and Infarction--Middle-Cerebral-Artery
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[Experimental studies on the anti-thrombosis effect of 3,4-oxo-isopropylidene-shikimic acid].
To study the effect of 3,4-oxo-isopropylidene-shikimic acid (ISA) against arteriovenous shunt and middle cerebral artery thrombosis (MCAT) in rats.. Arteriovenous shunt model was adopted to measure thrombus weight; The neurologic deficit (ND) and the infarct size (IS) of the middle cerebral thrombosis (MCAT) model induced by FeCl3 were observed; The effect of ISA on platelet aggregation rate of rat and rabbit by giving ISA in vivo and in vitro was studied.. ISA 25, 50, 100 and 200 mg.kg-1 ig was shown to reduced the weight of thrombus in arteriovenous shunt model; ISA 50, 100 and 200 mg.kg-1 ig for 2 times in 24 hours, attenuated the ND of rats subjected to MCAT; ISA 100 and 200 mg.kg-1 reduced IS of rats after MCAT by 27.8% and 31.6%, respectively; ISA 50, 100 and 200 mg.kg-1 ig inhibited platelet aggregation of normal rats; ISA 10(-3)-10(-5) mol.L-1, inhibited rabbit platelet aggregation in vitro.. ISA inhibited thrombosis by anti-platelet-aggregation. Topics: Animals; Brain; Disease Models, Animal; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Male; Platelet Aggregation; Rabbits; Random Allocation; Rats; Rats, Wistar; Shikimic Acid | 2002 |