3,4-methylenedioxyamphetamine has been researched along with Pyrexia in 20 studies
3,4-Methylenedioxyamphetamine: An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons and has been used for that purpose experimentally.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We showed that MDMA metabolites exhibited toxicity to SH-SY5Y differentiated cells, being the GSH and NAC conjugates more toxic than their catecholic precursors and MDMA." | 1.40 | "Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites. ( Barbosa, DJ; Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Fernandes, E; Ferreira, LM; Silva, R, 2014) |
| " Our findings support the view that COMT plays a pivotal role in determining the toxic response to MDMA." | 1.40 | Catechol-o-methyltransferase and 3,4-({+/-})-methylenedioxymethamphetamine toxicity. ( Cholanians, AB; Herndon, JM; Lau, SS; Lizarraga, LE; Monks, TJ, 2014) |
| " Curiously, the approximate elimination half-life (t(1/2)) of MDMA at 18 degrees C (136 min) and 31 degrees C (144 min) was increased compared with 24 degrees C (90 min) and is most likely because of volume of distribution changes induced by core temperature alterations." | 1.34 | Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys. ( Banks, ML; Czoty, PW; Kisor, DF; Nader, MA; Nichols, DE; Sprague, JE, 2007) |
| " After repeated dosing (8 x 20 mg/kg, i." | 1.31 | Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat. ( Boland, G; Kelly, JP; O'Boyle, KM; O'Loinsigh, ED, 2001) |
| "[3H]-paroxetine binding was also decreased by 27% in the cortex, indicating that the amine loss reflected a neurodegenerative change." | 1.29 | The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. ( Colado, MI; Green, AR; Williams, JL, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 12 (60.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barbosa, DJ | 1 |
| Capela, JP | 1 |
| Silva, R | 1 |
| Ferreira, LM | 1 |
| Branco, PS | 1 |
| Fernandes, E | 1 |
| Bastos, ML | 1 |
| Carvalho, F | 1 |
| Herndon, JM | 1 |
| Cholanians, AB | 1 |
| Lizarraga, LE | 1 |
| Lau, SS | 1 |
| Monks, TJ | 1 |
| Sprague, JE | 2 |
| Banks, ML | 2 |
| Cook, VJ | 1 |
| Mills, EM | 1 |
| McNamara, R | 1 |
| Kerans, A | 1 |
| O'Neill, B | 1 |
| Harkin, A | 1 |
| Kisor, DF | 1 |
| Czoty, PW | 1 |
| Nichols, DE | 1 |
| Nader, MA | 1 |
| Colado, MI | 3 |
| Williams, JL | 1 |
| Green, AR | 3 |
| Watson, JD | 1 |
| Ferguson, C | 1 |
| Hinds, CJ | 1 |
| Skinner, R | 1 |
| Coakley, JH | 1 |
| Larner, AJ | 1 |
| Webb, C | 1 |
| Williams, V | 1 |
| Tehan, B | 1 |
| Hardern, R | 1 |
| Bodenham, A | 1 |
| Iwersen, S | 1 |
| Schmoldt, A | 1 |
| Hall, AP | 1 |
| Liberg, JP | 1 |
| Hovda, KE | 1 |
| Nordby, G | 1 |
| Jacobsen, D | 1 |
| Granados, R | 1 |
| O'Shea, E | 2 |
| Esteban, B | 2 |
| O'Loinsigh, ED | 1 |
| Boland, G | 1 |
| Kelly, JP | 1 |
| O'Boyle, KM | 1 |
| Mechan, AO | 1 |
| Elliott, JM | 1 |
| Screaton, GR | 1 |
| Singer, M | 1 |
| Cairns, HS | 1 |
| Thrasher, A | 1 |
| Sarner, M | 1 |
| Cohen, SL | 1 |
| Woods, JD | 1 |
| Henry, JA | 1 |
| Chadwick, IS | 1 |
| Curry, PD | 1 |
| Linsley, A | 1 |
| Freemont, AJ | 1 |
| Doran, B | 1 |
| Brown, C | 1 |
| Osterloh, J | 1 |
2 reviews available for 3,4-methylenedioxyamphetamine and Pyrexia
| Article | Year |
|---|---|
Exertional heat stroke induced by amphetamine analogues. Does dantrolene have a place?
Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Adult; Blood Coagulation Disorders; Dancing; Dantrolene; | 1993 |
Hyperthermia associated with 3,4-methylenedioxyethamphetamine ('Eve').
Topics: 3,4-Methylenedioxyamphetamine; Adult; Designer Drugs; Fever; Humans; Male; Poisoning; Substance-Rela | 1993 |
18 other studies available for 3,4-methylenedioxyamphetamine and Pyrexia
| Article | Year |
|---|---|
"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.
Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Caspase 3; Cell Death; Cell Differentiation; Cell Lin | 2014 |
Catechol-o-methyltransferase and 3,4-({+/-})-methylenedioxymethamphetamine toxicity.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Base Sequence; Benzophenones; Catechol O-Methyltransferase; | 2014 |
Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy).
Topics: 3,4-Methylenedioxyamphetamine; Adrenergic alpha-Antagonists; Animals; Drug Interactions; Fever; Hypo | 2003 |
Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love").
Topics: 3,4-Methylenedioxyamphetamine; Animals; Area Under Curve; Behavior, Animal; Body Temperature; Brain | 2006 |
Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Body Temperature; Deoxyepinephrine; Fever; Hallucinogens; Ma | 2007 |
The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Body Temperature Regulation; Brain; Cytochrome P-450 CYP2D6; | 1995 |
Dantrolene and 'ecstasy' overdose.
Topics: 3,4-Methylenedioxyamphetamine; Dantrolene; Designer Drugs; Fever; Humans; N-Methyl-3,4-methylenediox | 1993 |
Ecstasy intoxication: appreciation of complications and the role of dantrolene.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Dantrolene; Designer Drugs; Fever; Humans; Male; N-Methyl-3,4- | 1993 |
Two very different fatal cases associated with the use of methylenedioxyethylamphetamine (MDEA): Eve as deadly as Adam.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Designer Drugs; Fatal Outcome; Fever; Humans; Male; Psychoses, | 1996 |
Ecstasy: creatinine kinase.
Topics: 3,4-Methylenedioxyamphetamine; Creatine Kinase; Dantrolene; Designer Drugs; Fever; Humans; Multiple | 1997 |
[Ecstasy--cool dope with long-lasting effects?].
Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Adult; Female; Fever; Hallucinogens; Humans; Seizures | 1998 |
The acute effect in rats of 3,4-methylenedioxyethamphetamine (MDEA, "eve") on body temperature and long term degeneration of 5-HT neurones in brain: a comparison with MDMA ("ecstasy").
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Cerebral Cortex; Dose-Response Relation | 1999 |
Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Biogenic Monoamines; Brain; Dopamine; Fever; Locomotion; Mal | 2001 |
The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats.
Topics: 3,4-Methylenedioxyamphetamine; Acute Disease; Animals; Benzazepines; Body Temperature; Corpus Striat | 2002 |
Hyperpyrexia and rhabdomyolysis after MDMA ("ecstasy") abuse.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Fever; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; R | 1992 |
Hyperpyrexia induced by 3,4-methylenedioxyamphetamine ("Eve")
Topics: 3,4-Methylenedioxyamphetamine; Adult; Fever; Humans; Male; Substance-Related Disorders | 1992 |
Ecstasy, 3-4 methylenedioxymethamphetamine (MDMA), a fatality associated with coagulopathy and hyperthermia.
Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Designer Drugs; Disseminated Intravascular Coagulation; F | 1991 |
Multiple severe complications from recreational ingestion of MDMA ('Ecstasy')
Topics: 3,4-Methylenedioxyamphetamine; Adult; Amphetamines; Female; Fever; Hallucinations; Humans; N-Methyl- | 1987 |