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3,4-methylenedioxyamphetamine and Nervous System Disorders

3,4-methylenedioxyamphetamine has been researched along with Nervous System Disorders in 23 studies

3,4-Methylenedioxyamphetamine: An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons and has been used for that purpose experimentally.

Research Excerpts

ExcerptRelevanceReference
" For future research, challenge studies in animals using dosing regimens adapted to human consumption patterns are needed."2.42The Neuropsychopharmacology and Toxicology of 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA). ( Freudenmann, RW; Spitzer, M, 2004)
" Perhaps as a consequence of this, the toxic effects of MDMA in the monkey involve serotonergic nerve fibers as well as cell bodies, whereas in the rat, only nerve fibers are affected."2.38Studies of MDMA-induced neurotoxicity in nonhuman primates: a basis for evaluating long-term effects in humans. ( Ricaurte, GA, 1989)
"Regulation of neurotoxicants is generally based on setting allowable doses (exposures) by dividing a no observed adverse effect level (NOAEL) by uncertainty factors that hopefully account for interspecies and intraspecies differences for extrapolations of experimental results obtained in animals to humans."1.28Risk assessment for neurotoxic effects. ( Gaylor, DW; Slikker, W, 1990)
" However, a comparison of the relative toxic effects of MDMA and MBDB indicates that MBDB may be slightly less neurotoxic."1.28Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration. ( Johnson, MP; Nichols, DE, 1989)
" The central monoamine stores of rats were significantly decreased with reserpine (5 mg/kg) prior to toxic injections of MDMA."1.28Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced neurotoxicity in the rat. ( Hekmatpanah, CR; McKenna, DJ; Peroutka, SJ, 1989)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19908 (34.78)18.7374
1990's14 (60.87)18.2507
2000's1 (4.35)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Freudenmann, RW1
Spitzer, M1
Brodkin, J1
Malyala, A1
Nash, JF1
Merrill, J1
Saunders, N1
Winstock, AR1
King, LA1
Grob, CS1
Bravo, GL1
Walsh, RN1
Liester, MB1
Steele, TD2
Katz, JL1
Ricaurte, GA2
Brewster, WK1
Johnson, MP2
Nichols, DE2
Yim, GK1
Schmidt, CJ3
Black, CK2
Taylor, VL2
Gaylor, DW1
Slikker, W1
Paris, JM1
Cunningham, KA1
Markert, LE1
Roberts, DC1
Grob, C1
Bravo, G1
Walsh, R1
Gibb, JW2
Johnson, M2
Hanson, GR2
Stone, DM1
Bush, LG1
Peroutka, SJ2
Hekmatpanah, CR1
McKenna, DJ1
Barnes, DM1
Logan, BJ1
Laverty, R1
Sanderson, WD1
Yee, YB1

Reviews

3 reviews available for 3,4-methylenedioxyamphetamine and Nervous System Disorders

ArticleYear
The Neuropsychopharmacology and Toxicology of 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA).
    CNS drug reviews, 2004,Summer, Volume: 10, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Drug Administration Schedule; Drug Interactions; Europe; Hal

2004
Acute and long-term neurochemical effects of methylenedioxymethamphetamine in the rat.
    NIDA research monograph, 1989, Volume: 94

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain Chemistry; N-Methyl-3,4-methylenedioxyam

1989
Studies of MDMA-induced neurotoxicity in nonhuman primates: a basis for evaluating long-term effects in humans.
    NIDA research monograph, 1989, Volume: 94

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Humans; N-Methyl-3,4-methylenedioxyamphetamine

1989

Trials

1 trial available for 3,4-methylenedioxyamphetamine and Nervous System Disorders

ArticleYear
Second thoughts on 3,4-methylenedioxymethamphetamine (MDMA) neurotoxicity.
    Archives of general psychiatry, 1990, Volume: 47, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Clinical Trials as Topic; Designer Drugs; Huma

1990

Other Studies

19 other studies available for 3,4-methylenedioxyamphetamine and Nervous System Disorders

ArticleYear
Effect of acute monoamine depletion on 3,4-methylenedioxymethamphetamine-induced neurotoxicity.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; alpha-Methyltyrosine; Animals; Axons; Biogenic Monoamines; Brain Chem

1993
Ecstasy and neurodegeneration. Advice is that "less is more".
    BMJ (Clinical research ed.), 1996, Aug-17, Volume: 313, Issue:7054

    Topics: 3,4-Methylenedioxyamphetamine; Chronic Disease; Designer Drugs; Humans; Nervous System Diseases; Ris

1996
Ecstasy and neurodegeneration. No evidence of neurotoxicity exists.
    BMJ (Clinical research ed.), 1996, Aug-17, Volume: 313, Issue:7054

    Topics: 3,4-Methylenedioxyamphetamine; Brain Diseases; Chronic Disease; Designer Drugs; Humans; Nervous Syst

1996
Ecstasy and neurodegeneration. Tablets often contain substances in addition to, or instead of, ecstasy...
    BMJ (Clinical research ed.), 1996, Aug-17, Volume: 313, Issue:7054

    Topics: 3,4-Methylenedioxyamphetamine; Designer Drugs; Drug Contamination; Humans; Nervous System Diseases;

1996
The MDMA-neurotoxicity controversy: implications for clinical research with novel psychoactive drugs.
    The Journal of nervous and mental disease, 1992, Volume: 180, Issue:6

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Combined Modality Therapy; Designer Drugs; Humans; Mental Di

1992
Evaluation of the neurotoxicity of N-methyl-1-(4-methoxyphenyl)-2-aminopropane (para-methoxymethamphetamine, PMMA).
    Brain research, 1992, Sep-04, Volume: 589, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain Chemistry; Hallucinogens; Hydroxyindolea

1992
Assessment of the role of alpha-methylepinine in the neurotoxicity of MDMA.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Biogenic Amines; Brain Chemistry; Chromatography, High Press

1991
L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats.
    European journal of pharmacology, 1991, Oct-02, Volume: 203, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dopamine;

1991
Risk assessment for neurotoxic effects.
    Neurotoxicology, 1990,Summer, Volume: 11, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Axons; Designer Drugs; Female; Hippocampus; Hydroxyindoleace

1990
Lack of neurotoxicity after intra-raphe micro-injections of MDMA ("ecstasy").
    NIDA research monograph, 1990, Volume: 105

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Catecholamines; Chromatography, High Pressu

1990
3,4-Methylenedioxyamphetamine (MDA) self-administration and neurotoxicity.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Biogenic Monoamines; Brain Chemistry; Chromatography, High P

1991
Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine.
    European journal of pharmacology, 1990, May-31, Volume: 181, Issue:1-2

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Aromatic Amino Acid Decarboxylase Inhibitors;

1990
Neurochemical basis of neurotoxicity.
    Neurotoxicology, 1990,Summer, Volume: 11, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Animals; Biogenic Monoamines; Designer Drugs; Dopamine; Glutamates; M

1990
Glucocorticoids and 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity.
    European journal of pharmacology, 1989, Feb-28, Volume: 161, Issue:2-3

    Topics: 3,4-Methylenedioxyamphetamine; Adrenalectomy; Amphetamines; Animals; Cerebral Cortex; Corticosterone

1989
Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:1

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Monoamines; Brain Chemistry; Hydroxyi

1989
'Ecstasy': a human neurotoxin?
    Archives of general psychiatry, 1989, Volume: 46, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Nervous

1989
Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced neurotoxicity in the rat.
    Neuroscience letters, 1989, Sep-25, Volume: 104, Issue:1-2

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Cerebral Cortex; Corpus Striatum; Designer Dru

1989
New data intensify the agony over ecstasy.
    Science (New York, N.Y.), 1988, Feb-19, Volume: 239, Issue:4842

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Haplorhini; Humans; Legislation, Drug;

1988
Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) neurotoxicity.
    European journal of pharmacology, 1988, Aug-02, Volume: 152, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Monoamines; Dopamine; Male; Methoxyhy

1988