3,4-methylenedioxyamphetamine has been researched along with Encephalopathy, Toxic in 9 studies
3,4-Methylenedioxyamphetamine: An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons and has been used for that purpose experimentally.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We showed that MDMA metabolites exhibited toxicity to SH-SY5Y differentiated cells, being the GSH and NAC conjugates more toxic than their catecholic precursors and MDMA." | 1.40 | "Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites. ( Barbosa, DJ; Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Fernandes, E; Ferreira, LM; Silva, R, 2014) |
| "3,4-Methylenedioxymethamphetamine (MDMA)'s O-demethylenated metabolite, 3,4-dihydroxymethamphetamine (HHMA), has been hypothesized to serve as a precursor for the formation of toxic catechol-thioether metabolites (e." | 1.37 | Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity. ( Maldonado Adrian, C; McCann, UD; Mueller, M; Ricaurte, GA; Yuan, J, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barbosa, DJ | 1 |
| Capela, JP | 1 |
| Silva, R | 1 |
| Ferreira, LM | 1 |
| Branco, PS | 1 |
| Fernandes, E | 1 |
| Bastos, ML | 1 |
| Carvalho, F | 1 |
| Herndon, JM | 1 |
| Cholanians, AB | 1 |
| Lau, SS | 3 |
| Monks, TJ | 3 |
| Weber, GF | 1 |
| Johnson, BN | 1 |
| Yamamoto, BK | 1 |
| Gudelsky, GA | 1 |
| Mueller, M | 3 |
| Kolbrich, EA | 1 |
| Peters, FT | 2 |
| Maurer, HH | 2 |
| McCann, UD | 3 |
| Huestis, MA | 1 |
| Ricaurte, GA | 3 |
| Yuan, J | 2 |
| Felim, A | 1 |
| Neudörffer, A | 1 |
| Largeron, M | 1 |
| Maldonado Adrian, C | 1 |
| Sprague, JE | 1 |
| Banks, ML | 1 |
| Cook, VJ | 1 |
| Mills, EM | 1 |
| Jones, DC | 2 |
| Bai, F | 2 |
1 review available for 3,4-methylenedioxyamphetamine and Encephalopathy, Toxic
| Article | Year |
|---|---|
The role of metabolism in 3,4-(+)-methylenedioxyamphetamine and 3,4-(+)-methylenedioxymethamphetamine (ecstasy) toxicity.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Blood-Brain Barrier; Catechols; Hallucinogens; Humans; Illic | 2004 |
8 other studies available for 3,4-methylenedioxyamphetamine and Encephalopathy, Toxic
| Article | Year |
|---|---|
"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.
Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Caspase 3; Cell Death; Cell Differentiation; Cell Lin | 2014 |
Glial cell response to 3,4-(+/-)-methylenedioxymethamphetamine and its metabolites.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Coculture T | 2014 |
Effects of stress and MDMA on hippocampal gene expression.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Gene Expression Regulation; Hippocampus; Neurotoxicity Syndr | 2014 |
Direct comparison of (+/-) 3,4-methylenedioxymethamphetamine ("ecstasy") disposition and metabolism in squirrel monkeys and humans.
Topics: 3,4-Methylenedioxyamphetamine; Adolescent; Animals; Brain; Chromatography, High Pressure Liquid; Dru | 2009 |
Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Deoxyepinephrine; Disease Models, Animal; Male; N-Methyl-3,4 | 2009 |
Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2011 |
Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy).
Topics: 3,4-Methylenedioxyamphetamine; Adrenergic alpha-Antagonists; Animals; Drug Interactions; Fever; Hypo | 2003 |
Serotonergic neurotoxicity of 3,4-(+/-)-methylenedioxyamphetamine and 3,4-(+/-)-methylendioxymethamphetamine (ecstasy) is potentiated by inhibition of gamma-glutamyl transpeptidase.
Topics: 3,4-Methylenedioxyamphetamine; Administration, Cutaneous; Animals; Brain; Endothelium; Enzyme Inhibi | 2001 |