3-4-methylenedioxy-beta-nitrostyrene has been researched along with Colitis* in 2 studies
2 other study(ies) available for 3-4-methylenedioxy-beta-nitrostyrene and Colitis
| Article | Year |
|---|---|
Discovery of 4-((E)-3,5-dimethoxy-2-((E)-2-nitrovinyl)styryl)aniline derivatives as potent and orally active NLRP3 inflammasome inhibitors for colitis.
NLRP3 inflammasome activation plays a key role in a variety of inflammatory diseases as IBD. Here a series of pterostilbene derivatives were designed and synthesized based on previous SAR, leading to discovery of new effective NLRP3 inflammasome inhibitors with metabolic stability. Among them, the most effective compound 27 showed high inhibitory efficacy (against IL-1 β: IC Topics: Aniline Compounds; Animals; Cell Line; Colitis; Inflammasomes; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein | 2022 |
Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis.
Studies have shown that the abnormal activation of the NLRP3 inflammasome is involved in a variety of inflammatory-based diseases. In this study, a high content screening model targeting the activation of inflammasome was first established and pterostilbene was discovered as the active scaffold. Based on this finding, total of 50 pterostilbene derivatives were then designed and synthesized. Among them, compound Topics: Animals; Anti-Inflammatory Agents; Cell Line; Colitis; Dextran Sulfate; Female; Humans; Inflammasomes; Interleukin-1beta; Macrophages; Male; Mice, Inbred C57BL; Molecular Structure; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Stilbenes; Structure-Activity Relationship | 2021 |