Compounds > 3-4-methylenedioxy-3--4--5--trimethoxy-chalcone

3-4-methylenedioxy-3--4--5--trimethoxy-chalcone and Tuberculosis

3-4-methylenedioxy-3--4--5--trimethoxy-chalcone has been researched along with Tuberculosis* in 1 studies

Other Studies

1 other study(ies) available for 3-4-methylenedioxy-3--4--5--trimethoxy-chalcone and Tuberculosis

Article	Year
Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23 In the search for lead compounds for new drugs for tuberculosis, the activity of 38 synthetic chalcones were assayed for their potential inhibitory action towards a protein tyrosine phosphatase from Mycobacterium tuberculosis--PtpA. The compounds were obtained by aldolic condensation between aldehydes and acetophenones, under basic conditions. Five compounds presented moderate or good activity. The structure-activity analysis reveals that the predominant factor for the activity is the molecule planarity/hydrophobicity and the nature of the substituents. Topics: Bacterial Proteins; Chalcones; Combinatorial Chemistry Techniques; Drug Resistance, Bacterial; Molecular Structure; Mycobacterium tuberculosis; Protein Tyrosine Phosphatases; Structure-Activity Relationship; Tuberculosis	2008

Article

Year

Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.

Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23

In the search for lead compounds for new drugs for tuberculosis, the activity of 38 synthetic chalcones were assayed for their potential inhibitory action towards a protein tyrosine phosphatase from Mycobacterium tuberculosis--PtpA. The compounds were obtained by aldolic condensation between aldehydes and acetophenones, under basic conditions. Five compounds presented moderate or good activity. The structure-activity analysis reveals that the predominant factor for the activity is the molecule planarity/hydrophobicity and the nature of the substituents.

Topics: Bacterial Proteins; Chalcones; Combinatorial Chemistry Techniques; Drug Resistance, Bacterial; Molecular Structure; Mycobacterium tuberculosis; Protein Tyrosine Phosphatases; Structure-Activity Relationship; Tuberculosis

2008