Compounds > 3-4-dihydroxyphenylpropionic-acid

3-4-dihydroxyphenylpropionic-acid and Breast-Neoplasms

3-4-dihydroxyphenylpropionic-acid has been researched along with Breast-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for 3-4-dihydroxyphenylpropionic-acid and Breast-Neoplasms

Article	Year
Anticancer activity of phenolic acids of natural or synthetic origin: a structure-activity study. Journal of medicinal chemistry, 2003, Dec-04, Volume: 46, Issue:25 Several phenolic acids-caffeic and gallic acid derivatives-were synthesized and screened for their potential antiproliferative and cytotoxic properties, in different human cancer cell lines: mammary gland and cervix adenocarcinomas and lymphoblastic leukemia. The selected phenols were structurally related, which allowed us to gather important information regarding the structure-activity relationships underlying the biological activity of such compounds. This is proposed to be due to a balance between the antioxidant and pro-oxidant properties of this kind of agent. Distinct effects were found for different cell lines, which points to a significant specificity of action of the drugs tested. It was verified, for the types of cancer investigated, that the trihydroxylated derivatives yielded better results than the dihydroxylated ones. Tests in noncancerous cells, human lung fibroblasts, were also undertaken, in view of determining the toxic side effects of the compounds studied. Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Caffeic Acids; Cell Division; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Female; Gallic Acid; Humans; Leukemia, Lymphoid; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Phenols; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Uterine Cervical Neoplasms	2003
Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids. Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:1 Ten esters each of caffeic acid and dihydrocaffeic acid have recently been synthesized. Cytotoxicity evaluations of these esters versus L1210 leukemia and MCF-7 breast cancer cells in culture have led to the delineation of substantially different QSAR for each series. The L1210 QSAR for dihydrocaffeic acid esters resembles the QSAR obtained for simple phenols and estrogenic phenols. However, the QSAR pertaining to the caffeic acid esters differs considerably from its sister QSAR. This difference may be attributed to the presence of the olefinic linkage in the side chain. The octyl ester of caffeic acid is nearly ten times as toxic to the leukemia cells than the widely studied phenethyl ester, CAPE. Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Caffeic Acids; Cell Division; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Esters; Leukemia L1210; Mice; Models, Theoretical; Structure-Activity Relationship; Tumor Cells, Cultured	2001

Article

Year

Anticancer activity of phenolic acids of natural or synthetic origin: a structure-activity study.

Journal of medicinal chemistry, 2003, Dec-04, Volume: 46, Issue:25

Several phenolic acids-caffeic and gallic acid derivatives-were synthesized and screened for their potential antiproliferative and cytotoxic properties, in different human cancer cell lines: mammary gland and cervix adenocarcinomas and lymphoblastic leukemia. The selected phenols were structurally related, which allowed us to gather important information regarding the structure-activity relationships underlying the biological activity of such compounds. This is proposed to be due to a balance between the antioxidant and pro-oxidant properties of this kind of agent. Distinct effects were found for different cell lines, which points to a significant specificity of action of the drugs tested. It was verified, for the types of cancer investigated, that the trihydroxylated derivatives yielded better results than the dihydroxylated ones. Tests in noncancerous cells, human lung fibroblasts, were also undertaken, in view of determining the toxic side effects of the compounds studied.

Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Caffeic Acids; Cell Division; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Female; Gallic Acid; Humans; Leukemia, Lymphoid; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Phenols; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Uterine Cervical Neoplasms

2003

Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids.

Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:1

Ten esters each of caffeic acid and dihydrocaffeic acid have recently been synthesized. Cytotoxicity evaluations of these esters versus L1210 leukemia and MCF-7 breast cancer cells in culture have led to the delineation of substantially different QSAR for each series. The L1210 QSAR for dihydrocaffeic acid esters resembles the QSAR obtained for simple phenols and estrogenic phenols. However, the QSAR pertaining to the caffeic acid esters differs considerably from its sister QSAR. This difference may be attributed to the presence of the olefinic linkage in the side chain. The octyl ester of caffeic acid is nearly ten times as toxic to the leukemia cells than the widely studied phenethyl ester, CAPE.

Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Caffeic Acids; Cell Division; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Esters; Leukemia L1210; Mice; Models, Theoretical; Structure-Activity Relationship; Tumor Cells, Cultured

2001