3,4-dihydroxyphenylglycol and Fragile X Syndrome

Topics: Animals; Fragile X Mental Retardation Protein; Fragile X Syndrome; Hippocampus; Methoxyhydroxyphenylglycol; Mice, Inbred C57BL; Neuronal Plasticity; Peptide Elongation Factor 2; Protein Binding; Protein Biosynthesis; Receptors, Metabotropic Glutamate; Ribosomes; RNA 5' Terminal Oligopyrimidine Sequence; Signal Transduction; Tuberous Sclerosis Complex 2 Protein

Topics: Adenosine; Animals; Baclofen; Data Interpretation, Statistical; Electrophysiological Phenomena; Excitatory Postsynaptic Potentials; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA Agonists; Hippocampus; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Neurons; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Synapses

Topics: Case-Control Studies; Cells, Cultured; Child; Child, Preschool; Cytokines; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fragile X Mental Retardation Protein; Fragile X Syndrome; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Methoxyhydroxyphenylglycol; Mitogens; Phytohemagglutinins; Pyridines; Receptors, Metabotropic Glutamate; Statistics, Nonparametric; Thiazoles; Trinucleotide Repeat Expansion

Topics: Animals; Cell Differentiation; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Fragile X Syndrome; Humans; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neural Stem Cells; Pyridines; Receptor, Metabotropic Glutamate 5

Topics: Age Factors; Animals; Biophysics; CA3 Region, Hippocampal; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Fragile X Mental Retardation Protein; Fragile X Syndrome; In Vitro Techniques; Long-Term Synaptic Depression; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses

Topics: Adaptor Proteins, Signal Transducing; Animals; CA1 Region, Hippocampal; Carrier Proteins; Cell Cycle Proteins; Cognition Disorders; Disease Models, Animal; Eukaryotic Initiation Factor-4A; Eukaryotic Initiation Factors; Excitatory Postsynaptic Potentials; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Expression Regulation; Immunoprecipitation; In Vitro Techniques; Long-Term Synaptic Depression; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Receptors, Metabotropic Glutamate; Serine; Signal Transduction; Sirolimus

Topics: Analysis of Variance; Animals; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Dendrites; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Hippocampus; Humans; Immunoprecipitation; Luminescent Proteins; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Models, Biological; Neurons; Phosphatidylinositol 3-Kinases; Protein Subunits; Receptors, AMPA; Red Fluorescent Protein; RNA, Messenger; Synapses; Synaptosomes; Transfection

Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Benzopyrans; Cells, Cultured; Dendritic Spines; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Hippocampus; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Neurons; Pyridines; Receptors, Metabotropic Glutamate; Signal Transduction; Silver Staining

Topics: Aminoquinolines; Analysis of Variance; Animals; Brain; Dendrites; Dendritic Spines; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Expression Regulation; In Vitro Techniques; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Patch-Clamp Techniques; Pyrimidines; rac1 GTP-Binding Protein; Signal Transduction; Silver Staining; Synapses

Topics: Action Potentials; Animals; Cortical Synchronization; Fragile X Mental Retardation Protein; Fragile X Syndrome; gamma-Aminobutyric Acid; Interneurons; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Mice, Knockout; Neural Inhibition; Organ Culture Techniques; Phenotype; Pyramidal Cells; Receptors, Metabotropic Glutamate; Somatosensory Cortex; Somatostatin; Synaptic Transmission

Topics: Analysis of Variance; Animals; Carrier Proteins; Cycloheximide; Disease Models, Animal; Electric Stimulation; Exploratory Behavior; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Expression Regulation; Hippocampus; Homer Scaffolding Proteins; Immunoprecipitation; In Vitro Techniques; Long-Term Potentiation; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Net; Patch-Clamp Techniques; Peptides; Physics; Protein Synthesis Inhibitors; Rats; Rats, Long-Evans; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Serine; Signal Transduction; TOR Serine-Threonine Kinases

Topics: Adaptor Proteins, Signal Transducing; Animals; Behavior, Animal; Disease Models, Animal; DNA Copy Number Variations; Excitatory Amino Acid Antagonists; Fragile X Syndrome; Gene Order; Genotype; Haploinsufficiency; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Nerve Tissue Proteins; Phenotype; Protein Biosynthesis; Receptors, Glutamate

Topics: Analysis of Variance; Animals; Behavior, Animal; Biophysics; Dendritic Spines; Disease Models, Animal; Electric Stimulation; Excitatory Postsynaptic Potentials; Exploratory Behavior; Extracellular Signal-Regulated MAP Kinases; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Interpersonal Relations; Long-Term Synaptic Depression; Male; Maze Learning; Membrane Potentials; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Mutation; Neurons; Patch-Clamp Techniques; Phenotype; Phosphorylation; Recognition, Psychology; Ribosomal Protein S6 Kinases, 70-kDa; Rotarod Performance Test; Synapses; TOR Serine-Threonine Kinases

Topics: 2-Amino-5-phosphonovalerate; Animals; Anisomycin; Blotting, Western; Disease Models, Animal; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Fragile X Mental Retardation Protein; Fragile X Syndrome; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Neurons; Protein Biosynthesis; Protein Synthesis Inhibitors; Receptors, Metabotropic Glutamate