3-4-dihydroxyphenylethanol-elenolic-acid-dialdehyde and Inflammation

3-4-dihydroxyphenylethanol-elenolic-acid-dialdehyde has been researched along with Inflammation* in 2 studies

Other Studies

2 other study(ies) available for 3-4-dihydroxyphenylethanol-elenolic-acid-dialdehyde and Inflammation

Article	Year
Oleacein Attenuates Lipopolysaccharide-Induced Inflammation in THP-1-Derived Macrophages by the Inhibition of TLR4/MyD88/NF-κB Pathway. International journal of molecular sciences, 2022, Jan-21, Volume: 23, Issue:3 Topics: Aldehydes; Anti-Inflammatory Agents; Cytokines; Humans; Inflammation; Lipopolysaccharides; Macrophages; Myeloid Differentiation Factor 88; NF-kappa B; Phenols; Signal Transduction; Toll-Like Receptor 4	2022
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation. Nutrients, 2019, Nov-21, Volume: 11, Issue:12 Inflammation of the adipose tissue plays an important role in the development of several chronic diseases associated with obesity. Polyphenols of extra virgin olive oil (EVOO), such as the secoiridoids oleocanthal (OC) and oleacein (OA), have many nutraceutical proprieties. However, their roles in obesity-associated adipocyte inflammation, the NF-κB pathway and related sub-networks have not been fully elucidated. Here, we investigated impact of OC and OA on the activation of NF-κB and the expression of molecules associated with inflammatory and dysmetabolic responses. To this aim, fully differentiated Simpson-Golabi-Behmel syndrome (SGBS) adipocytes were pre-treated with OC or OA before stimulation with TNF-α. EVOO polyphenols significantly reduced the expression of genes implicated in adipocyte inflammation (IL-1β, COX-2), angiogenesis (VEGF/KDR, MMP-2), oxidative stress (NADPH oxidase), antioxidant enzymes (SOD and GPX), leukocytes chemotaxis and infiltration (MCP-1, CXCL-10, MCS-F), and improved the expression of the anti-inflammatory/metabolic effector PPARγ. Accordingly, miR-155-5p, miR-34a-5p and let-7c-5p, tightly connected with the NF-κB pathway, were deregulated by TNF-α in both cells and exosomes. The miRNA modulation and NF-κB activation by TNF-α was significantly counteracted by EVOO polyphenols. Computational studies suggested a potential direct interaction between OC and NF-κB at the basis of its activity. This study demonstrates that OC and OA counteract adipocyte inflammation attenuating NF-κB activation. Therefore, these compounds could be novel dietary tools for the prevention of inflammatory diseases associated with obesity. Topics: Adipocytes; Aldehydes; Cells, Cultured; Cyclopentane Monoterpenes; Exosomes; Gene Expression Regulation; Humans; Inflammation; MicroRNAs; NF-kappa B; Phenols; Signal Transduction	2019

Article

Year

Oleacein Attenuates Lipopolysaccharide-Induced Inflammation in THP-1-Derived Macrophages by the Inhibition of TLR4/MyD88/NF-κB Pathway.

International journal of molecular sciences, 2022, Jan-21, Volume: 23, Issue:3

Topics: Aldehydes; Anti-Inflammatory Agents; Cytokines; Humans; Inflammation; Lipopolysaccharides; Macrophages; Myeloid Differentiation Factor 88; NF-kappa B; Phenols; Signal Transduction; Toll-Like Receptor 4

2022

The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation.

Nutrients, 2019, Nov-21, Volume: 11, Issue:12

Inflammation of the adipose tissue plays an important role in the development of several chronic diseases associated with obesity. Polyphenols of extra virgin olive oil (EVOO), such as the secoiridoids oleocanthal (OC) and oleacein (OA), have many nutraceutical proprieties. However, their roles in obesity-associated adipocyte inflammation, the NF-κB pathway and related sub-networks have not been fully elucidated. Here, we investigated impact of OC and OA on the activation of NF-κB and the expression of molecules associated with inflammatory and dysmetabolic responses. To this aim, fully differentiated Simpson-Golabi-Behmel syndrome (SGBS) adipocytes were pre-treated with OC or OA before stimulation with TNF-α. EVOO polyphenols significantly reduced the expression of genes implicated in adipocyte inflammation (IL-1β, COX-2), angiogenesis (VEGF/KDR, MMP-2), oxidative stress (NADPH oxidase), antioxidant enzymes (SOD and GPX), leukocytes chemotaxis and infiltration (MCP-1, CXCL-10, MCS-F), and improved the expression of the anti-inflammatory/metabolic effector PPARγ. Accordingly, miR-155-5p, miR-34a-5p and let-7c-5p, tightly connected with the NF-κB pathway, were deregulated by TNF-α in both cells and exosomes. The miRNA modulation and NF-κB activation by TNF-α was significantly counteracted by EVOO polyphenols. Computational studies suggested a potential direct interaction between OC and NF-κB at the basis of its activity. This study demonstrates that OC and OA counteract adipocyte inflammation attenuating NF-κB activation. Therefore, these compounds could be novel dietary tools for the prevention of inflammatory diseases associated with obesity.

Topics: Adipocytes; Aldehydes; Cells, Cultured; Cyclopentane Monoterpenes; Exosomes; Gene Expression Regulation; Humans; Inflammation; MicroRNAs; NF-kappa B; Phenols; Signal Transduction

2019