3,4-dihydroxyphenylacetic acid has been researched along with Nervous System Disorders in 21 studies
3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.
(3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Most studies on E neuroprotection use chronic administration of the steroid to evaluate its beneficial effect." | 1.32 | Dopamine transporter as a marker of neuroprotection in methamphetamine-lesioned mice treated acutely with estradiol. ( D'Astous, M; Di Paolo, T; Dluzen, DE; Gajjar, TM, 2004) |
| " We show in this study that repin is highly toxic to C57BL/6J mice and Sprague-Dawley rats and acutely induces uncoordinated locomotion associated with postural tremors, hypothermia, and inability to respond to sonic and tactile stimuli." | 1.30 | Repin-induced neurotoxicity in rodents. ( Choi, BH; Han, B; Kim, RC; Robles, M; Santa Cruz, K, 1998) |
| "Patients with neurogenic orthostatic hypotension can have deficits in sympathetic neural function at any of several levels of the sympathetic neuraxis." | 1.28 | Patterns of plasma levels of catechols in neurogenic orthostatic hypotension. ( Biaggioni, I; Brown, RT; Garty, M; Goldstein, DS; Kopin, IJ; Polinsky, RJ; Robertson, D; Stull, R, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (38.10) | 18.7374 |
| 1990's | 9 (42.86) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, X | 1 |
| Zhang, L | 1 |
| Fu, S | 1 |
| Li, N | 1 |
| Aubin, N | 1 |
| Barneoud, P | 1 |
| Carter, C | 1 |
| Caille, D | 1 |
| Sontag, N | 1 |
| Marc, C | 1 |
| Lolivier, J | 1 |
| Gardes, A | 1 |
| Perron, C | 1 |
| Le Kim, A | 1 |
| Charieras, T | 1 |
| Pandini, M | 1 |
| Burnier, P | 1 |
| Puech, F | 1 |
| Jegham, S | 1 |
| George, P | 1 |
| Scatton, B | 1 |
| Curet, O | 1 |
| D'Astous, M | 1 |
| Gajjar, TM | 1 |
| Dluzen, DE | 2 |
| Di Paolo, T | 1 |
| Seiden, LS | 1 |
| Vosmer, G | 1 |
| Vizuete, ML | 1 |
| Steffen, V | 1 |
| Machado, A | 1 |
| Cano, J | 1 |
| Oishi, T | 1 |
| Hasegawa, E | 1 |
| Murai, Y | 1 |
| Hastings, TG | 1 |
| Lewis, DA | 1 |
| Zigmond, MJ | 1 |
| Robles, M | 1 |
| Choi, BH | 1 |
| Han, B | 1 |
| Santa Cruz, K | 1 |
| Kim, RC | 1 |
| Wakata, N | 1 |
| Araki, Y | 1 |
| Sugimoto, H | 1 |
| Iguchi, H | 1 |
| Kinoshita, M | 1 |
| Garrett, MC | 1 |
| Soares-da-Silva, P | 1 |
| Naudin, B | 1 |
| Saligaut, C | 1 |
| Costentin, J | 1 |
| O'Dell, SJ | 1 |
| Weihmuller, FB | 1 |
| Marshall, JF | 1 |
| Carr, LA | 1 |
| Rowell, PP | 1 |
| Goldstein, DS | 1 |
| Polinsky, RJ | 1 |
| Garty, M | 1 |
| Robertson, D | 1 |
| Brown, RT | 1 |
| Biaggioni, I | 1 |
| Stull, R | 1 |
| Kopin, IJ | 2 |
| Fuller, RW | 1 |
| Hemrick-Luecke, SK | 1 |
| Johnson, EA | 1 |
| Wu, EY | 1 |
| Rollema, H | 2 |
| Booth, RG | 2 |
| Trevor, AJ | 1 |
| Castagnoli, N | 2 |
| Corsini, GU | 1 |
| Pintus, S | 1 |
| Chiueh, CC | 1 |
| Weiss, JF | 1 |
| Youngster, SK | 1 |
| Sonsalla, PK | 1 |
| Heikkila, RE | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Norepinephrine Transporter Blockade as a Pathophysiological Biomarker in Neurogenic Orthostatic Hypotension[NCT01316666] | 50 participants (Actual) | Observational | 2011-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
21 other studies available for 3,4-dihydroxyphenylacetic acid and Nervous System Disorders
| Article | Year |
|---|---|
Co-involvement of psychological and neurological abnormalities in infertility with polycystic ovarian syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anxiety; Checklist; Depression; Diagnostic Self Evaluation; Dopamine | 2011 |
SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Brain; Corpus Striatum; Disease Models, Anim | 2004 |
Dopamine transporter as a marker of neuroprotection in methamphetamine-lesioned mice treated acutely with estradiol.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Chromatography, High Pressure Liquid; Coca | 2004 |
Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single large dose of methylamphetamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caudate Nucleus; Dopamine; Hydroxydopamines; Male; Methamph | 1984 |
1-Methyl-4-phenylpyridinium has greater neurotoxic effect after selenium deficiency than after vitamin E deficiency in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Weight; Dopamine; Eating; Free Radicals; Glutathione P | 1994 |
Sulfhydryl drugs reduce neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striat | 1993 |
Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Catecholamine | 1996 |
Reactive dopamine metabolites and neurotoxicity: implications for Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catechols; Cysteine; Dopamine; Free Radicals; Histocytochem | 1996 |
Repin-induced neurotoxicity in rodents.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cytotoxins; Dopamine; Encephalomalacia; Glutathione; Immuno | 1998 |
IDPN-induced monoamine and hydroxyl radical changes in the rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Dopamine; Homovanillic Acid; Hy | 2000 |
Increased cerebrospinal fluid dopamine and 3,4-dihydroxyphenylacetic acid levels in Huntington's disease: evidence for an overactive dopaminergic brain transmission.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Biogenic Amines; Brain; Dopamine; Female; Humans; Huntington | 1992 |
Influence of oxygen availability on the neurotoxic effect of 6-hydroxydopamine on nigro-striatal dopaminergic neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Atmospheric Pressure; Chromatography, High Pressure Liquid; | 1991 |
Multiple methamphetamine injections induce marked increases in extracellular striatal dopamine which correlate with subsequent neurotoxicity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caudate Nucleus; Corpus Striatum; Dialysis; Dopamine; Extra | 1991 |
Attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity by tobacco smoke.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striat | 1990 |
Patterns of plasma levels of catechols in neurogenic orthostatic hypotension.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Catecholamines; Dihydroxyphenylalanine; Humans; Hypotension, | 1989 |
A high dose of MPTP overcomes the protective effect of selegiline against dopaminergic neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striat | 1989 |
1-methyl-4-phenylpyridinium (MPP+) analogs: in vivo neurotoxicity and inhibition of striatal synaptosomal dopamine uptake.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dialysis; Dop | 1989 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by pretreatment with diethyldithiocarbamate.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amin | 1985 |
In vivo dopaminergic neurotoxicity of the 2-beta-methylcarbolinium ion, a potential endogenous MPP+ analog.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Carbolines; Corpus Striatum; D | 1988 |
Evaluation of the biological activity of several analogs of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Corpus | 1987 |
Differential neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Swiss-Webster mice from different sources.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemist | 1985 |