3,4-dihydroxyphenylacetic acid has been researched along with Lesch-Nyhan Syndrome in 5 studies
3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.
(3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tschirner, SK | 1 |
| Gutzki, F | 1 |
| Kaever, V | 1 |
| Seifert, R | 1 |
| Schneider, EH | 1 |
| Bavaresco, CS | 1 |
| Chiarani, F | 1 |
| Duringon, E | 1 |
| Ferro, MM | 1 |
| Cunha, CD | 1 |
| Netto, CA | 1 |
| Wyse, AT | 1 |
| Smith, DW | 2 |
| Jinnah, HA | 3 |
| Wojcik, BE | 1 |
| Hunt, M | 1 |
| Narang, N | 1 |
| Lee, KY | 1 |
| Goldstein, M | 1 |
| Wamsley, JK | 1 |
| Langlais, PJ | 1 |
| Friedmann, T | 2 |
| Visser, JE | 1 |
| Moy, SS | 1 |
| Breese, GR | 1 |
| Rothstein, JD | 1 |
5 other studies available for 3,4-dihydroxyphenylacetic acid and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Altered histamine neurotransmission in HPRT-deficient mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Histamine; Homovanillic Acid; Hypoxanthine | 2015 |
Intrastriatal injection of hypoxanthine reduces striatal serotonin content and impairs spatial memory performance in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Hydroxyindole | 2007 |
Role of neuronal nitric oxide in the dopamine deficit of HPRT-deficient mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Female; Homovanillic Acid; Hypoxanthine Phosphori | 2007 |
Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain; Caudate Nucleus; Disease Models, Animal; Dopa | 1994 |
Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aconitate Hydratase; Animals; Cell Death; Disease Models, Animal; Do | 2002 |