3,4-dihydroxyphenylacetic acid has been researched along with Hypertension in 39 studies
3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.
(3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of the intravenous administration of dihydroergotoxine (6 micrograms/kg) on arterial blood pressure, heart rate, and plasma concentrations of norepinephrine and 3,4-dihydroxyphenylacetic acid (the deaminated dopamine metabolite) was studied in 20 subjects with essential hypertension (8 men and 12 women aged 32-68 years old, World Health Organization Class I-II)." | 5.06 | Peripheral dopamine receptors in the antihypertensive action of dihydroergotoxine in humans. ( Cherchi, A; Gessa, G; Mercuro, G; Rivano, CA; Rossetti, ZL; Ruscazio, M; Tocco, L, 1987) |
| " The plasma concentrations of the rat natriuretic hormone oxytocin, which has implications for the development of hypertension, and vasopressin (AVP) were also measured." | 3.73 | CNS-induced natriuresis, neurohypophyseal peptides and renal dopamine and noradrenaline excretion in prehypertensive salt-sensitive Dahl rats. ( Hansell, P; Lee, SL; Sjöquist, M, 2005) |
| " In SHR, phenylephrine-induced hypertension produced no significant changes in the extracellular norepinephrine (NE) and dihydroxyphenylacetic acid concentrations, whereas a significant increase in the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) concentration was observed." | 3.69 | Extracellular catechol and indole turnover in the nucleus of the solitary tract of spontaneously hypertensive and Wistar-Kyoto normotensive rats in response to drug-induced changes in arterial blood pressure. ( Dev, BR; Philip, L, 1996) |
| " To test the hypothesis that LY171555 inhibits in vivo release of DA and its metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), from central dopaminergic neurons of the conscious, freely moving rat by activation of presynaptic DA receptors in the central nervous system and that this mechanism may be altered in the desoxycorticosterone acetate (DOCA)/NaCl model of hypertension, we used the in vivo push-pull perfusion method to study the effect of LY171555 on central DA release in normotensive and DOCA/NaCl-hypertensive rats." | 3.67 | Enhanced response to the inhibitory action of LY171555, a dopamine D2-agonist, on in vivo striatal dopamine release in DOCA/NaCl-hypertensive rats. ( Chen, YF; Oparil, S, 1987) |
| " To test the hypotheses that quinpirole inhibits in vivo release of DA from central dopaminergic neurons by activation of DA receptors in the central nervous system (CNS) and that this mechanism may be altered in the desoxycorticosterone acetate (DOCA)/NaCl model of hypertension, we examined the effects of quinpirole on stores of DA and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in brain regions of 4-week DOCA/NaCl-hypertensive rats and their normotensive controls." | 3.67 | Altered responsiveness of regional brain dopamine and DOPAC levels to systemic administration of quinpirole, a dopamine D2 agonist, in DOCA/NaCl-hypertensive rats. ( Chen, YF; Gist, R; Jin, HK; Oparil, S, 1987) |
| "This study on the role of the sympathetic nervous system in the development of hypertension involves the measurement of dopamine and norepinephrine accumulation in various tissues of the hypertensive and random-bred normotensive strains of mice at basal levels, and following a pargyline-L-dopa treatment." | 3.67 | L-dopa metabolism in genetically hypertensive mice: effect of pargyline. ( Buu, NT; Duhaime, J; Kuchel, O; Racz, K; Schlager, G, 1987) |
| " Its bioavailability is, however, low and, therefore, its metabolites could rather be responsible for this effect." | 1.56 | A Mixture of Phenolic Metabolites of Quercetin Can Decrease Elevated Blood Pressure of Spontaneously Hypertensive Rats Even in Low Doses. ( Mladěnka, P; Najmanová, I; Pourová, J, 2020) |
| "The hypertensive patients with chronic renal failure shared with their hypertensive counterparts without chronic renal failure an impaired DOPA decarboxylation to dopamine." | 1.29 | Dopaminergic abnormalities in hypertension associated with moderate renal insufficiency. ( Kuchel, OG; Shigetomi, S, 1994) |
| " Compared to WKY, the dose-response curve for the inhibition of dopamine release by quinpirole was shifted to the left in SHR and the maximal inhibition in response to the highest dose was significantly greater." | 1.28 | Effect of the dopamine D2 receptor agonist quinpirole on the in vivo release of dopamine in the caudate nucleus of hypertensive rats. ( De Jong, W; De Lang, H; Linthorst, AC; Versteeg, DH, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (43.59) | 18.7374 |
| 1990's | 16 (41.03) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Najmanová, I | 2 |
| Pourová, J | 2 |
| Mladěnka, P | 2 |
| Vopršalová, M | 1 |
| Migkos, T | 1 |
| Pilařová, V | 1 |
| Applová, L | 1 |
| Nováková, L | 1 |
| Sjöquist, M | 1 |
| Lee, SL | 1 |
| Hansell, P | 2 |
| Höcht, C | 2 |
| Opezzo, JA | 2 |
| Taira, CA | 2 |
| Mayer, MA | 1 |
| Peredo, HA | 1 |
| Navacchia, D | 1 |
| Fernández, BE | 1 |
| Puyó, AM | 1 |
| Neff, NH | 2 |
| Karoum, F | 2 |
| Hadjiconstantinou, M | 1 |
| Howes, LG | 1 |
| Rowe, PR | 1 |
| Summers, RJ | 1 |
| Louis, WJ | 1 |
| Weinberger, MH | 1 |
| Luft, FC | 1 |
| Henry, DP | 1 |
| Hoffmann, P | 1 |
| Elam, M | 1 |
| Thorén, P | 1 |
| Hjorth, S | 1 |
| Lambert, GW | 1 |
| Ferrier, C | 1 |
| Kaye, DM | 1 |
| Kalff, V | 1 |
| Kelly, MJ | 1 |
| Cox, HS | 1 |
| Turner, AG | 1 |
| Jennings, GL | 1 |
| Esler, MD | 1 |
| Kirouac, GJ | 1 |
| Ganguly, PK | 1 |
| Linthorst, AC | 3 |
| van Giersbergen, PL | 1 |
| Gras, M | 1 |
| Versteeg, DH | 2 |
| de Jong, W | 3 |
| Kuchel, OG | 1 |
| Shigetomi, S | 2 |
| Yao, H | 1 |
| Nagao, T | 1 |
| Ooboshi, H | 1 |
| Matsumoto, T | 1 |
| Hirano, M | 1 |
| Nakahara, T | 1 |
| Sadoshima, S | 1 |
| Uchimura, H | 1 |
| Fujishima, M | 1 |
| Sanada, H | 1 |
| Watanabe, H | 1 |
| Fukuchi, S | 1 |
| Versteeg, HG | 1 |
| Möller, B | 1 |
| Dev, BR | 1 |
| Philip, L | 1 |
| Kuchel, O | 3 |
| Pestana, M | 1 |
| Jardim, H | 1 |
| Correia, F | 1 |
| Vieira-Coelho, MA | 1 |
| Soares-da-Silva, P | 1 |
| Lütold, BE | 1 |
| De Lang, H | 1 |
| Ghosh, D | 1 |
| Anyanwu, BO | 1 |
| Guilford, J | 1 |
| Henderson, LL | 1 |
| Dawson, R | 3 |
| Wallace, DR | 1 |
| Yu, ZJ | 1 |
| Lim, DK | 1 |
| Hoskins, B | 1 |
| Rockhold, RW | 1 |
| Ho, IK | 1 |
| Sim, MK | 1 |
| Hsu, TP | 1 |
| Oparil, S | 3 |
| Meldrum, MJ | 1 |
| Bhaskaran, D | 1 |
| Freed, CR | 1 |
| McKeon, TW | 1 |
| Hendley, ED | 1 |
| Chen, YF | 2 |
| Jin, HK | 1 |
| Gist, R | 1 |
| Koulu, M | 1 |
| Saavedra, JM | 1 |
| Niwa, M | 1 |
| Linnoila, M | 1 |
| Luthringer, C | 1 |
| Trouvin, JH | 1 |
| Laurant, P | 1 |
| Jacquot, C | 1 |
| Berthelot, A | 1 |
| Buu, NT | 2 |
| Duhaime, J | 1 |
| Racz, K | 2 |
| Schlager, G | 1 |
| Debinski, W | 1 |
| Falardeau, P | 1 |
| Mercuro, G | 2 |
| Rossetti, Z | 1 |
| Rivano, AC | 1 |
| Tocco, L | 2 |
| Ruscazio, M | 2 |
| Stefanini, E | 1 |
| Gessa, GL | 1 |
| Cherchi, A | 2 |
| Rossetti, ZL | 1 |
| Rivano, CA | 1 |
| Gessa, G | 1 |
| Denoroy, L | 1 |
| Sautel, M | 1 |
| Sacquet, J | 1 |
| Vincent, M | 1 |
| Sassard, J | 1 |
2 reviews available for 3,4-dihydroxyphenylacetic acid and Hypertension
| Article | Year |
|---|---|
Dopamine-containing small intensely fluorescent cells and sympathetic ganglion function.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Fluorescence; Ganglia, Sympathetic; Hypertension; | 1983 |
Renal dopaminergic mechanisms in renal parenchymal diseases and hypertension.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Pressure; Disease Models, Animal; Dopamine; Homovanil | 2001 |
1 trial available for 3,4-dihydroxyphenylacetic acid and Hypertension
| Article | Year |
|---|---|
Peripheral dopamine receptors in the antihypertensive action of dihydroergotoxine in humans.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Blood Pressure; Depression, Chemical; Dihydroergotoxine | 1987 |
36 other studies available for 3,4-dihydroxyphenylacetic acid and Hypertension
| Article | Year |
|---|---|
A Mixture of Phenolic Metabolites of Quercetin Can Decrease Elevated Blood Pressure of Spontaneously Hypertensive Rats Even in Low Doses.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antihypertensive Agents; Biological Availability; Blood Pre | 2020 |
Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antihypertensive Agents; Aorta, Thoracic; Arterial Pressure | 2018 |
CNS-induced natriuresis, neurohypophyseal peptides and renal dopamine and noradrenaline excretion in prehypertensive salt-sensitive Dahl rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cerebrospinal Fluid; Dopamine; Hypertension; Male; Natriure | 2005 |
Hypothalamic antihypertensive effect of metoprolol in chronic aortic coarctated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antihypertensive Agents; Aortic Coarctation; Female; Heart | 2005 |
Role of hypothalamic alpha-adrenoceptor activity in fructose-induced hypertension.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anterior Hypothalamic Nucleus; Antibody Formation; Blood Pr | 2006 |
Age related changes of catecholamines and their metabolites in central nervous system regions of spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Blood Pressure; Brain Chemistry; Brain Stem; C | 1984 |
The role of the sympathetic nervous system in the modulation of sodium excretion.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Catecholamines; Dopamine; Humans; Hypertension; Kidney; Male; | 1982 |
Effects of long-lasting voluntary running on the cerebral levels of dopamine, serotonin and their metabolites in the spontaneously hypertensive rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Hydroxyindoleacetic Acid; Hypertension; Ma | 1994 |
Monoaminergic neuronal activity in subcortical brain regions in essential hypertension.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Biogenic Monoamines; Brain; Cerebrovascular Circulation; Homo | 1994 |
Cholecystokinin-induced release of dopamine in the nucleus accumbens of the spontaneously hypertensive rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Pressure; Cholecystokinin; Dopamine; Histocytochemist | 1995 |
The nigrostriatal dopamine system: role in the development of hypertension in spontaneously hypertensive rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Pressure; Caudate Nucleus; Dopamine; Heart Rate; Homo | 1994 |
Dopaminergic abnormalities in hypertension associated with moderate renal insufficiency.
Topics: 3,4-Dihydroxyphenylacetic Acid; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Diastole; Dih | 1994 |
Ischemia-induced changes in brain monoamine metabolism in aged spontaneously hypertensive rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Biogenic Monoamines; Brain; Corpus Striatum; Dopamin | 1993 |
Gene expression of aromatic L-amino acid decarboxylase mRNA in the kidney of normotensive and hypertensive rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Gene Expression Regul | 1995 |
The nigrostriatal dopamine system and the development of hypertension in the spontaneously hypertensive rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caudate Nucleus; Dopamine; Homovanillic Acid; Hypertension; | 1995 |
Sodium and dopamine excretion in prehypertensive Dahl rats during severe hypervolaemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Pressure; Blood Volume; Dopamine; Glomerular Filtrati | 1995 |
Extracellular catechol and indole turnover in the nucleus of the solitary tract of spontaneously hypertensive and Wistar-Kyoto normotensive rats in response to drug-induced changes in arterial blood pressure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Pressure; Hydroxyindoleacetic Acid; Hypertension; Hyp | 1996 |
Differential catecholamine responses to protein intake in healthy and hypertensive subjects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Dietary Prot | 1998 |
Deficient dopamine metabolism in the celiac ganglion of spontaneously hypertensive rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Pressure; Catecholamines; Dopamine; Ganglia, Autonomi | 1979 |
Effect of the dopamine D2 receptor agonist quinpirole on the in vivo release of dopamine in the caudate nucleus of hypertensive rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Pressure; Caudate Nucleus; Desoxycorticosterone; Dial | 1991 |
Effects of L-tryptophan on the brainstem indole and catecholamine metabolites in spontaneously hypertensive rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Stem; Catecholamines; Hypertension; Indoles; Male; Ra | 1991 |
Neural-renal interactions in the hypertension induced by papillary necrosis: role of dietary salt intake.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Glands; Animals; Blood Pressure; Dopamine; Ethylamines; Hype | 1990 |
Effects of acute and subacute cocaine administration on the CNS dopaminergic system in Wistar-Kyoto and spontaneously hypertensive rats: I. Levels of dopamine and metabolites.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cocaine; Corpus Striatum; Dopamine; Homovanillic Acid; Hype | 1990 |
Levels of dopamine and 3,4-dihydroxyphenylacetic acid in the adenohypophysis of normo- and hypertensive rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography; Dopamine; Homovanillic Acid; Hypertension; | 1990 |
Genetic and salt-related alterations in monoamine neurotransmitters in Dahl salt-sensitive and salt-resistant rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Pressure; Catecholamines; Hydroxyindoleacetic Acid; H | 1986 |
Increased 3,4-dihydroxyphenylacetic acid (DOPAC) levels in spontaneously hypertensive rats (SHR) during the development of hypertension.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Homovanillic Acid; Hydroxyindoleacetic Acid; Hypertension; | 1988 |
Changes in neurotransmitter turnover in locus coeruleus produced by changes in arterial blood pressure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Pressure; Hydroxyindoleacetic Acid; Hypertension; Hyp | 1988 |
Brain monoamines and metabolites in hypertensive and hyperactive rat strains.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Biogenic Monoamines; Brain Chemistry; Dopamine; Fema | 1988 |
Enhanced response to the inhibitory action of LY171555, a dopamine D2-agonist, on in vivo striatal dopamine release in DOCA/NaCl-hypertensive rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography; Corpus Striatum; Desoxycorticosterone; Dopa | 1987 |
Altered responsiveness of regional brain dopamine and DOPAC levels to systemic administration of quinpirole, a dopamine D2 agonist, in DOCA/NaCl-hypertensive rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Desoxycorticosterone; Dopamine; Ergolines; | 1987 |
Increased catecholamine metabolism in the locus coeruleus of young spontaneously hypertensive rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Stem; Catecholamines; Dihydroxyphenylalanine; Dopamin | 1986 |
Effects of high magnesium intake on central catecholamines in spontaneously hypertensive rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Catecholamines; Diet; Dopamine; Homovanillic Acid; H | 1988 |
L-dopa metabolism in genetically hypertensive mice: effect of pargyline.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Weight; Brain; Dopamine; Dopamine beta-Hydroxylase; Dr | 1987 |
Contrasting dopaminergic patterns in two forms of genetic hypertension.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Glands; Animals; Dopamine; Dopamine beta-Hydroxylase; Gangli | 1987 |
[Peripheral presynaptic dopamine receptors control the release of norepinephrine and arterial pressure in humans].
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Apomorphine; Blood Pressure; Bromocriptine; Dihydroergotoxine | 1987 |
Brain, spinal cord and adrenal catecholamine concentrations in neonate rats of the Lyon hypertensive strain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Medulla; Animals; Catecholamines; Central Nervous System; Do | 1985 |