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3,4-dihydroxyphenylacetic acid and Hepatic Encephalopathy

3,4-dihydroxyphenylacetic acid has been researched along with Hepatic Encephalopathy in 4 studies

3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.
(3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
"Intracerebral microdialysis was applied to monitor the neocortical extracellular levels of the aromatic amino acids phenylalanine, tyrosine, and tryptophan, the neurotransmitters dopamine (DA), noradrenaline (NA), and serotonin (5-HT), and the metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole-3-acetic acid (5-HIAA) in rats with various forms of experimental hepatic encephalopathy (HE)."3.69Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt. ( Bengtsson, F; Bergqvist, PB; Bosman, DK; Chamuleau, RA; Hjorth, S; Maas, MA; Vogels, BA, 1995)
"Acute hepatic encephalopathy (HE) is associated with disturbances in motor functions, but the underlying mechanisms remain obscure."1.30N-methyl-D-aspartate-evoked changes in the striatal extracellular levels of dopamine and its metabolites in vivo in rats with acute hepatic encephalopathy. ( Albrecht, J; Borkowska, HD; Hilgier, W; Oja, OS; Oja, SS; Saransaari, P, 1999)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bergqvist, PB1
Vogels, BA1
Bosman, DK1
Maas, MA1
Hjorth, S1
Chamuleau, RA1
Bengtsson, F1
Hadesman, R1
Wiesner, RH1
Go, VL1
Tyce, GM1
Bergeron, M1
Swain, MS1
Reader, TA1
Butterworth, RF1
Borkowska, HD1
Oja, SS1
Oja, OS1
Saransaari, P1
Hilgier, W1
Albrecht, J1

Other Studies

4 other studies available for 3,4-dihydroxyphenylacetic acid and Hepatic Encephalopathy

ArticleYear
Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt.
    Journal of neurochemistry, 1995, Volume: 64, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acute Disease; Amino Acids; Ammonia; Animals; Biogenic Monoamines; B

1995
Concentrations of 3,4-dihydroxyphenylalanine and catecholamines and metabolites in brain in an anhepatic model of hepatic encephalopathy.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Chemistry; Catecholamines; Dihydroxyphenylalan

1995
Regional alterations of dopamine and its metabolites in rat brain following portacaval anastomosis.
    Neurochemical research, 1995, Volume: 20, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Anastomosis, Surgical; Animals; Brain; Dopamine; Hepatic Encephalopa

1995
N-methyl-D-aspartate-evoked changes in the striatal extracellular levels of dopamine and its metabolites in vivo in rats with acute hepatic encephalopathy.
    Neuroscience letters, 1999, Jun-25, Volume: 268, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists;

1999