Compounds > 3,4-dihydroxyphenylacetic acid
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3,4-dihydroxyphenylacetic acid and Drug Withdrawal Symptoms

3,4-dihydroxyphenylacetic acid has been researched along with Drug Withdrawal Symptoms in 39 studies

3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.
(3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.

Research Excerpts

ExcerptRelevanceReference
"The effects of GB-115 dipeptide, a retroanalog of endogenous CCK-4, on the behavioral indices in "elevated plus maze" (EPM) test and on the content of biogenic amines in the brain structures after discontinuation of a chronic administration of benzodiazepine (BZ) derivatives phenazepam (2."1.37[Effect of GB-115 dipeptide on anxiety in rats with model benzodiazepine withdrawal syndrome]. ( Gudasheva, TA; Kadnikov, IA; Kolik, LG; Seredenin, SB; Zhukov, VN, 2011)
"Triadimefon (TDF) is a triazole fungicide that blocks the reuptake of dopamine (DA) and leads to increased locomotor activity levels in mice and rats, effects similar to those of indirect DA agonists such as cocaine."1.32Development of behavioral sensitization to the cocaine-like fungicide triadimefon is prevented by AMPA, NMDa, DA D1 but not DA D2 receptor antagonists. ( Cory-Slechta, DA; Reeves, R; Thiruchelvam, M, 2004)
" In the present work we have studied the effects of acute and chronic administration of the kappa agonist U-50,488H as well as the influence of U-50,488H withdrawal on the activity of hypothalamic NA and dopamine (DA) neurons and on the activity of hypothalamic-pituitary-adrenal (HPA) axis."1.31Effects of U-50,488H and U-50,488H withdrawal on catecholaminergic neurons of the rat hypothalamus. ( Laorden, ML; Milanés, MV, 2000)
"Morphine withdrawal was precipitated by naltrexone administration to morphine-treated rats."1.31NO synthase inhibitors attenuate locus coeruleus catecholamine metabolism and behavior induced by morphine withdrawal. ( Bérod, A; Javelle, N; Lambás-Señas, L; Renaud, B, 2002)
"Morphine treatment also increased the glutamate/GABA ratio in the striatum."1.29Effects of morphine treatment and withdrawal on striatal and limbic monoaminergic activity and ascorbic acid oxidation in the rat. ( De Natale, G; Desole, MS; Enrico, P; Esposito, G; Fresu, L; Miele, E; Miele, M; Migheli, R; Mura, MA, 1996)
"Rats treated with haloperidol also showed an increase in 5-HIAA levels, possibly due to enhanced serotonin turnover."1.27Dopamine and serotonin metabolites in rat cerebroventricular fluid following withdrawal of haloperidol or electroshock treatment. ( Barkai, AI; Kowalik, S; Reches, A, 1984)
"Fluphenazine decanoate was administered chronically to rats on a schedule for which marked tolerance developed to acute fluphenazine effects on several parameters of dopaminergic neuronal function."1.26Tolerance to fluphenazine and supersensitivity to apomorphine in central dopaminergic systems after chronic fluphenazine decanoate treatment. ( Roth, RH; Wheeler, SC, 1980)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199012 (30.77)18.7374
1990's12 (30.77)18.2507
2000's9 (23.08)29.6817
2010's6 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhao, Z1
Kim, SC1
Zhao, R1
Wu, Y1
Zhang, J1
Liu, H1
Kim, YW1
Zhu, X1
Gu, C1
Lee, CW1
Lee, BH1
Jang, EY1
Ko, HL1
Yang, CH1
Hirth, N1
Meinhardt, MW1
Noori, HR1
Salgado, H1
Torres-Ramirez, O1
Uhrig, S1
Broccoli, L1
Vengeliene, V1
Roßmanith, M1
Perreau-Lenz, S1
Köhr, G1
Sommer, WH1
Spanagel, R1
Hansson, AC1
Natividad, LA1
Tejeda, HA1
Torres, OV1
O'Dell, LE1
Kolik, LG1
Kadnikov, IA1
Zhukov, VN1
Gudasheva, TA1
Seredenin, SB1
Yong, Z1
Yan, L1
Zhou, P1
Yu, G1
Dong, H1
Gong, Z1
Okamoto, R1
Itoh, Y1
Murata, Y1
Kobayashi, D1
Hosoi, M1
Mine, K1
Cerezo, M1
Laorden, ML4
Milanés, MV4
Reeves, R1
Thiruchelvam, M1
Cory-Slechta, DA1
Carlson, JN1
Drew Stevens, K1
Barkai, AI1
Kowalik, S1
Reches, A1
Clow, A1
Theodorou, A1
Jenner, P1
Marsden, CD1
Ahluwalia, P1
Singhal, RL3
Allikmets, LKh1
Nurk, AM1
Wheeler, SC1
Roth, RH2
Honkanen, A1
Piepponen, TP1
Ahtee, L3
Karoum, F1
Egan, MF1
Wyatt, RJ1
Paulson, PE1
Robinson, TE1
Desole, MS1
Esposito, G1
Fresu, L1
Migheli, R1
Enrico, P1
Mura, MA1
De Natale, G1
Miele, E1
Miele, M1
Javelle, N2
Renaud, B2
Lambás-Señas, L2
Hildebrand, BE4
Nomikos, GG3
Hertel, P1
Schilström, B1
Svensson, TH4
Ghosh, S1
Patel, AH1
Cousins, M1
Grasing, K1
Panagis, G2
Salminen, O1
Seppä, T1
Gäddnäs, H1
Fuertes, G1
Fuente, T1
Zhou, Q1
Nyberg, F1
Bérod, A1
Rastogi, RB2
Lapierre, YD2
Gramsch, C1
Bläsig, J1
Herz, A1
Gil, E1
Colado, I1
Lopez, F1
Fernandez-Briera, A1
Fernandez-Lopez, A1
Calvo, P1
Carey, RJ1
Attila, LM1
Carlson, KR1
Haikala, H1
Bagdy, G1
Perényi, A1
Frecska, E1
Révai, K1
Papp, Z1
Fekete, MI1
Arató, M1
Lewis, SJ1
Rowe, P1
Jarrott, B1
Ida, Y1

Other Studies

39 other studies available for 3,4-dihydroxyphenylacetic acid and Drug Withdrawal Symptoms

ArticleYear
The tegmental-accumbal dopaminergic system mediates the anxiolytic effect of acupuncture during ethanol withdrawal.
    Neuroscience letters, 2015, Jun-15, Volume: 597

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acupuncture Therapy; Animals; Anxiety; Dopamine; Ethanol; Male; Nucl

2015
Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, Mar-15, Volume: 113, Issue:11

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Alcohol Abstinence; Alcoholism; Animals; Benzazepines;

2016
Nicotine withdrawal produces a decrease in extracellular levels of dopamine in the nucleus accumbens that is lower in adolescent versus adult male rats.
    Synapse (New York, N.Y.), 2010, Volume: 64, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Bicuculline; Dopamine; Extracellular Space; GABA Ant

2010
[Effect of GB-115 dipeptide on anxiety in rats with model benzodiazepine withdrawal syndrome].
    Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:10

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Anxiety Diso

2011
Effects of thienorphine on release of dopamine and noradrenalin: an in vivo microdialysis study in rats.
    Neuroscience letters, 2012, Apr-04, Volume: 513, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analgesics, Opioid; Animals; Buprenorphine; Corpus Striatum; Dopamin

2012
Reduction of group II metabotropic glutamate receptors during development of benzodiazepine dependence.
    Pharmacology, 2013, Volume: 91, Issue:3-4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzodiazepines; Cerebral Cortex; Dopamine; Flumazenil; GAB

2013
Inhibition of protein kinase C but not protein kinase A attenuates morphine withdrawal excitation of rat hypothalamus-pituitary-adrenal axis.
    European journal of pharmacology, 2002, Sep-27, Volume: 452, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analgesics, Opioid; Animals; Blood-Brain Barrier; Catecholamines; Ch

2002
Development of behavioral sensitization to the cocaine-like fungicide triadimefon is prevented by AMPA, NMDa, DA D1 but not DA D2 receptor antagonists.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 79, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; B

2004
Individual differences in ethanol self-administration following withdrawal are associated with asymmetric changes in dopamine and serotonin in the medial prefrontal cortex and amygdala.
    Alcoholism, clinical and experimental research, 2006, Volume: 30, Issue:10

    Topics: 3,4-Dihydroxyphenylacetic Acid; Alcohol Drinking; Amygdala; Animals; Behavior, Animal; Central Nervo

2006
Dopamine and serotonin metabolites in rat cerebroventricular fluid following withdrawal of haloperidol or electroshock treatment.
    Psychopharmacology, 1984, Volume: 84, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Electroshock; Haloperidol; Homovanillic Acid; Hum

1984
Cerebral dopamine function in rats following withdrawal from one year of continuous neuroleptic administration.
    European journal of pharmacology, 1980, May-02, Volume: 63, Issue:2-3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Bindi

1980
Comparison of the changes in central catecholamine systems following short- and long-term lithium treatment and the consequences of lithium withdrawal.
    Neuropsychobiology, 1984, Volume: 12, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Dopamine; Homovanillic Aci

1984
[Effect of chronic administration of lithium chloride on the development of dopamine receptor sensitivity during morphine withdrawal in rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 92, Issue:11

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chlorides; Corpus Striatum; Dopamine; Homovanillic Acid; Hu

1981
Tolerance to fluphenazine and supersensitivity to apomorphine in central dopaminergic systems after chronic fluphenazine decanoate treatment.
    Naunyn-Schmiedeberg's archives of pharmacology, 1980, Volume: 312, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Brain; Brain Chemistry; Cerebral Cortex; Corpu

1980
Morphine-stimulated metabolism of striatal and limbic dopamine is dissimilarly sensitized in rats upon withdrawal from chronic morphine treatment.
    Neuroscience letters, 1994, Oct-24, Volume: 180, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Limbic System

1994
Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure.
    European journal of pharmacology, 1994, Mar-11, Volume: 254, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cocaine; Dopamine; Hypothalamus; Male; Prefrontal Cortex; R

1994
Regional differences in the effects of amphetamine withdrawal on dopamine dynamics in the striatum. Analysis of circadian patterns using automated on-line microdialysis.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1996, Volume: 14, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Caudate Nucleus; Circadian Rhythm; Dopamine; F

1996
Effects of morphine treatment and withdrawal on striatal and limbic monoaminergic activity and ascorbic acid oxidation in the rat.
    Brain research, 1996, Jun-03, Volume: 723, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Amines; Animals; Ascorbic Acid; Corpus Striatum; Dopamine; gamma-Ami

1996
Monoamine metabolism in the locus coeruleus measured concurrently with behavior during opiate withdrawal: an in vivo microdialysis study in freely moving rats.
    Journal of neurochemistry, 1997, Volume: 68, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analgesics, Opioid; Animals; Behavior, Animal; Biogenic Monoamines;

1997
Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome.
    Brain research, 1998, Jan-01, Volume: 779, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Behavior, Animal; Dopamine; Homovanil

1998
Different effects of opiate withdrawal on dopamine turnover, uptake, and release in the striatum and nucleus accumbens.
    Neurochemical research, 1998, Volume: 23, Issue:6

    Topics: 3,4-Dihydroxyphenylacetic Acid; 4-Aminopyridine; Animals; Corpus Striatum; Dopamine; Male; Morphine;

1998
Nicotine withdrawal in the rat: role of alpha7 nicotinic receptors in the ventral tegmental area.
    Neuroreport, 1999, Mar-17, Volume: 10, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dopamine; Homovani

1999
The effects of acute nicotine on the metabolism of dopamine and the expression of Fos protein in striatal and limbic brain areas of rats during chronic nicotine infusion and its withdrawal.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Sep-15, Volume: 19, Issue:18

    Topics: 3,4-Dihydroxyphenylacetic Acid; Amygdala; Animals; Caudate Nucleus; Corpus Striatum; Cotinine; Dopam

1999
Behavioral and biochemical manifestations of mecamylamine-precipitated nicotine withdrawal in the rat: role of nicotinic receptors in the ventral tegmental area.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 21, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Hydroxyindoleacetic Acid; Male; Mecamylamine; Mot

1999
Noradrenergic and dopaminergic activity in the hypothalamic paraventricular nucleus after naloxone-induced morphine withdrawal.
    Neuroendocrinology, 2000, Volume: 71, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Chroni

2000
Catecholaminergic activity and 3',5'-cyclic adenosine monophosphate levels in heart right ventricle after naloxone induced withdrawal.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 361, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Catecholamines; Cyclic AMP; Dopamine; Hea

2000
Effects of U-50,488H and U-50,488H withdrawal on catecholaminergic neurons of the rat hypothalamus.
    Life sciences, 2000, Jan-21, Volume: 66, Issue:9

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydr

2000
Intraaccumbal mecamylamine infusion does not affect dopamine output in the nucleus accumbens of chronically nicotine-treated rats.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:8-9

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Chronic Disease; Dopamine; Extracellular

2000
Injection of substance P (SP) N-terminal fragment SP(1-7) into the ventral tegmental area modulates the levels of nucleus accumbens dopamine and dihydroxyphenylacetic acid in male rats during morphine withdrawal.
    Neuroscience letters, 2002, Mar-08, Volume: 320, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Extracellular Space; Male; Microdialysis; Morphin

2002
NO synthase inhibitors attenuate locus coeruleus catecholamine metabolism and behavior induced by morphine withdrawal.
    Neuroreport, 2002, Apr-16, Volume: 13, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Catecholamines; Enzyme Inhibitors; Locus

2002
Evidence for the role of brain norepinephrine and dopamine in "rebound" phenomenon seen during withdrawal after repeated exposure to benzodiazepines.
    Journal of psychiatric research, 1977, Volume: 13, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Anxiety Agents; Body Weight; Brain; Brain Chemistry; B

1977
Some neurochemical correlates of "rebound" phenomenon observed during withdrawal after long-term exposure to 1, 4-benzodiazepines.
    Progress in neuro-psychopharmacology, 1978, Volume: 2, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Anxiety Agents; Brain; Brain Chemistry; Bromazepam; Di

1978
Changes in striatal dopamine metabolism during precipitated morphine withdrawal.
    European journal of pharmacology, 1977, Aug-01, Volume: 44, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzomorphans; Catechol O-Methyltransferase; Corpus Striatu

1977
Effects of chronic treatment with ethanol and withdrawal of ethanol on levels of dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid in the striatum of the rat. Influence of benzodiazepines, barbiturate and somatostatin.
    Neuropharmacology, 1992, Volume: 31, Issue:11

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Barbiturates; Benzodiazepines; Chromatography, High Pressur

1992
Chronic L-dopa treatment in the unilateral 6-OHDA rat: evidence for behavioral sensitization and biochemical tolerance.
    Brain research, 1991, Dec-24, Volume: 568, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Carbidopa; Corpus Striatum; Denervation; Drug

1991
Changes in brain monoamine metabolism during withdrawal from chronic oral self-administration of morphine and in response to a morphine challenge in the withdrawn state.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Biogenic Amines; Brain; Dopamine; Hyd

1989
Decrease in dopamine, its metabolites and noradrenaline in cerebrospinal fluid of schizophrenic patients after withdrawal of long-term neuroleptic treatment.
    Psychopharmacology, 1985, Volume: 85, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Antipsychotic Agents; Chronic Disease; Dopamine; Female; Halo

1985
Involvement of hypothalamic adrenaline in the clonidine withdrawal syndrome in normotensive and spontaneously hypertensive rats.
    Clinical and experimental pharmacology & physiology, 1988, Volume: 15, Issue:10

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clonidine; Dopamine; Epinephrine; Female; Hypothalamus; Med

1988
The activation of mesoprefrontal dopamine neurons by FG 7142 is absent in rats treated chronically with diazepam.
    European journal of pharmacology, 1987, Jun-04, Volume: 137, Issue:2-3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Appetite Depressants; Carbolines; Cerebral Cortex; Diazepam

1987