3,4-dihydroxyphenylacetic acid has been researched along with Depression in 41 studies
3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.
(3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Depression is one of the most common associated diseases, which aggravates psoriatic skin lesions and affects the life quality of patients." | 5.56 | Depressive-like behaviors in mice with Imiquimod-induced psoriasis. ( Di, T; Guo, J; Guo, X; Li, P; Liu, Y; Meng, Y; Qi, C; Wang, Y; Zhang, L; Zhao, J, 2020) |
| "We have measured the concentrations of dopamine, and the dopamine metabolites homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC), in five brain regions from suicide victims with a firm retrospective diagnosis of depression, and matched controls." | 3.69 | Reduced dopamine turnover in the basal ganglia of depressed suicides. ( Bowden, C; Cheetham, SC; Crompton, MR; Horton, RW; Katona, CL; Lowther, S, 1997) |
| "The authors report cerebrospinal fluid (CSF) concentrations of five monoamine metabolites before and after probenecid administration in normal subjects and patients with depression and schizophrenia." | 3.66 | CSF monoamine metabolites in depression and schizophrenia. ( Anderson, PJ; Barchas, JD; Berger, PA; Davis, KL; Faull, KF; Kilkowski, J; Kraemer, H, 1980) |
| "Depression is one of the most common associated diseases, which aggravates psoriatic skin lesions and affects the life quality of patients." | 1.56 | Depressive-like behaviors in mice with Imiquimod-induced psoriasis. ( Di, T; Guo, J; Guo, X; Li, P; Liu, Y; Meng, Y; Qi, C; Wang, Y; Zhang, L; Zhao, J, 2020) |
| "Depression is one of the main non-motor symptoms of PD." | 1.51 | Curcumin restores rotenone induced depressive-like symptoms in animal model of neurotoxicity: assessment by social interaction test and sucrose preference test. ( Haider, S; Madiha, S, 2019) |
| "In humans, depression is associated with altered rapid eye movement (REM) sleep." | 1.38 | Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats. ( Huang, ZL; Li, R; Qu, WM; Tu, ZC; Urade, Y; Wang, YQ; Xu, XY, 2012) |
| " Taken together, our data indicate that chronic use of stanozolol significantly affects brain monoamines leading to neurochemical modifications possibly involved in depression and stress-related states." | 1.38 | Neurochemical consequence of steroid abuse: stanozolol-induced monoaminergic changes. ( Colaianna, M; Cuomo, V; Morgese, MG; Schiavone, S; Trabace, L; Tucci, P; Zotti, M, 2012) |
| "Patients with Parkinson's disease have a decrement in homovanillic acid that is reversed by treatment with L-3,4-dihydroxyphenylalanine." | 1.27 | Monoamine metabolites in human cerebrospinal fluid. HPLC/ED method. ( Aguado, EG; de Yebenes, JG; Mena, MA, 1984) |
| "50 pmol/ml) did not change after 1 wk of Li dosing (1." | 1.27 | Differences in lithium effects in depressed and healthy subjects. ( Karoum, F; Linnoila, M; Potter, WZ; Ross, RJ; Rudorfer, MV, 1985) |
| "Two cases of depression are presented: One which responded to psychotherapy and the other which responded to medication." | 1.26 | Repertory grid and biochemical characterization of depression: a comparison of case reports. ( Berger, PA; Slater, P; Yesavage, JA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (17.07) | 18.7374 |
| 1990's | 6 (14.63) | 18.2507 |
| 2000's | 10 (24.39) | 29.6817 |
| 2010's | 12 (29.27) | 24.3611 |
| 2020's | 6 (14.63) | 2.80 |
| Authors | Studies |
|---|---|
| Bajaj, J | 1 |
| Dwivedi, J | 1 |
| Sahu, R | 1 |
| Dave, V | 1 |
| Verma, K | 1 |
| Joshi, S | 1 |
| Sati, B | 1 |
| Sharma, S | 1 |
| Seidel, V | 1 |
| Mishra, AP | 1 |
| de Melo Martins, GM | 1 |
| Petersen, BD | 1 |
| Rübensam, G | 1 |
| da Silva, JMK | 1 |
| Gaspary, KV | 1 |
| Wiprich, MT | 1 |
| Altenhofen, S | 1 |
| Bonan, CD | 1 |
| Tian, P | 1 |
| Zhang, W | 1 |
| Li, KY | 1 |
| Li, HW | 1 |
| Ma, K | 1 |
| Han, DE | 1 |
| Becker, M | 1 |
| Abaev, K | 1 |
| Shmerkin, E | 1 |
| Weinstein-Fudim, L | 1 |
| Pinhasov, A | 1 |
| Ornoy, A | 1 |
| Możdżeń, E | 1 |
| Babińska, I | 1 |
| Wójcikowski, J | 1 |
| Antkiewicz-Michaluk, L | 2 |
| Guo, J | 1 |
| Liu, Y | 1 |
| Guo, X | 2 |
| Meng, Y | 1 |
| Qi, C | 1 |
| Zhao, J | 1 |
| Di, T | 1 |
| Zhang, L | 2 |
| Wang, Y | 2 |
| Li, P | 1 |
| Monchaux De Oliveira, C | 1 |
| Pourtau, L | 1 |
| Vancassel, S | 1 |
| Pouchieu, C | 1 |
| Capuron, L | 1 |
| Gaudout, D | 1 |
| Castanon, N | 1 |
| Fujikawa, R | 1 |
| Higuchi, S | 1 |
| Ikedo, T | 1 |
| Nagata, M | 1 |
| Hayashi, K | 1 |
| Yang, T | 1 |
| Miyata, T | 1 |
| Yokode, M | 1 |
| Minami, M | 1 |
| Romańska, I | 1 |
| Wąsik, A | 1 |
| Michaluk, J | 1 |
| Khnychenko, LK | 1 |
| Yakovleva, EE | 1 |
| Bychkov, ER | 1 |
| Shabanov, PD | 1 |
| Madiha, S | 1 |
| Haider, S | 1 |
| Valles-Colomer, M | 1 |
| Falony, G | 1 |
| Darzi, Y | 1 |
| Tigchelaar, EF | 1 |
| Wang, J | 1 |
| Tito, RY | 1 |
| Schiweck, C | 1 |
| Kurilshikov, A | 1 |
| Joossens, M | 1 |
| Wijmenga, C | 1 |
| Claes, S | 1 |
| Van Oudenhove, L | 1 |
| Zhernakova, A | 1 |
| Vieira-Silva, S | 1 |
| Raes, J | 1 |
| Yu, Q | 1 |
| Teixeira, CM | 1 |
| Mahadevia, D | 1 |
| Huang, Y | 1 |
| Balsam, D | 1 |
| Mann, JJ | 1 |
| Gingrich, JA | 1 |
| Ansorge, MS | 1 |
| Topic, B | 1 |
| Oitzl, MS | 1 |
| Meijer, OC | 1 |
| Huston, JP | 1 |
| de Souza Silva, MA | 1 |
| Jaehne, EJ | 1 |
| Majumder, I | 1 |
| Salem, A | 1 |
| Irvine, RJ | 1 |
| Shi, X | 1 |
| Fu, S | 1 |
| Li, N | 1 |
| Wang, YQ | 1 |
| Tu, ZC | 1 |
| Xu, XY | 1 |
| Li, R | 1 |
| Qu, WM | 1 |
| Urade, Y | 1 |
| Huang, ZL | 1 |
| Tucci, P | 1 |
| Morgese, MG | 1 |
| Colaianna, M | 1 |
| Zotti, M | 1 |
| Schiavone, S | 1 |
| Cuomo, V | 1 |
| Trabace, L | 1 |
| Browne, CA | 1 |
| Clarke, G | 1 |
| Hanke, J | 1 |
| Dinan, TG | 1 |
| Schwegler, H | 1 |
| Yilmazer-Hanke, DM | 1 |
| Cryan, JF | 1 |
| Miura, H | 2 |
| Qiao, H | 2 |
| Ohta, T | 2 |
| Renard, CE | 1 |
| Dailly, E | 1 |
| David, DJ | 1 |
| Hascoet, M | 1 |
| Bourin, M | 1 |
| Wang, JX | 1 |
| Zhang, JJ | 1 |
| Zhong, GS | 1 |
| Zhang, DQ | 1 |
| Hu, SM | 1 |
| Li, W | 1 |
| Ou, LN | 1 |
| Gao, XM | 1 |
| Hellweg, R | 1 |
| Zueger, M | 1 |
| Fink, K | 1 |
| Hörtnagl, H | 1 |
| Gass, P | 1 |
| Krzyzowski, J | 1 |
| Lewicka-Wysocka, H | 1 |
| Lukaszewska, B | 1 |
| Marcjan, K | 1 |
| Pacyna, M | 1 |
| Pietruszewska, I | 1 |
| Roguska, E | 1 |
| Stencka, K | 1 |
| Mena, MA | 1 |
| Aguado, EG | 1 |
| de Yebenes, JG | 1 |
| Karoum, F | 2 |
| Chuang, LW | 1 |
| Eisler, T | 1 |
| Calne, DB | 1 |
| Liebowitz, MR | 1 |
| Quitkin, FM | 1 |
| Klein, DF | 1 |
| Wyatt, RJ | 1 |
| Berger, PA | 2 |
| Faull, KF | 1 |
| Kilkowski, J | 1 |
| Anderson, PJ | 1 |
| Kraemer, H | 1 |
| Davis, KL | 1 |
| Barchas, JD | 1 |
| Rossetti, ZL | 1 |
| Lai, M | 1 |
| Hmaidan, Y | 1 |
| Gessa, GL | 1 |
| Berlin, I | 1 |
| Said, S | 1 |
| Spreux-Varoquaux, O | 1 |
| Olivares, R | 1 |
| Launay, JM | 1 |
| Puech, AJ | 1 |
| Hickie, I | 1 |
| Hickie, C | 1 |
| Bennett, B | 1 |
| Wakefield, D | 1 |
| Silove, D | 1 |
| Mitchell, P | 1 |
| Lloyd, A | 1 |
| Bowden, C | 1 |
| Cheetham, SC | 1 |
| Lowther, S | 1 |
| Katona, CL | 1 |
| Crompton, MR | 1 |
| Horton, RW | 1 |
| Yamashita, K | 1 |
| Kitayama, I | 1 |
| Hamanaka, K | 1 |
| Nomura, J | 1 |
| Sallinen, J | 1 |
| Haapalinna, A | 1 |
| MacDonald, E | 1 |
| Viitamaa, T | 1 |
| Lähdesmäki, J | 1 |
| Rybnikova, E | 1 |
| Pelto-Huikko, M | 1 |
| Kobilka, BK | 1 |
| Scheinin, M | 1 |
| Ronan, PJ | 1 |
| Steciuk, M | 1 |
| Kramer, GL | 1 |
| Kram, M | 1 |
| Petty, F | 1 |
| Yadid, G | 1 |
| Overstreet, DH | 1 |
| Zangen, A | 1 |
| Ventura, R | 1 |
| Cabib, S | 1 |
| Puglisi-Allegra, S | 1 |
| Pallis, E | 1 |
| Thermos, K | 1 |
| Spyraki, C | 1 |
| Yesavage, JA | 1 |
| Slater, P | 1 |
| Goodwin, FK | 1 |
| Post, RM | 1 |
| Rudorfer, MV | 1 |
| Ross, RJ | 1 |
| Potter, WZ | 1 |
| Linnoila, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101] | 120 participants (Anticipated) | Observational | 2022-01-27 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 3,4-dihydroxyphenylacetic acid and Depression
| Article | Year |
|---|---|
Studies of amine metabolites in affective illness and in schizophrenia: a comparative analysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depressio | 1975 |
1 trial available for 3,4-dihydroxyphenylacetic acid and Depression
| Article | Year |
|---|---|
Monoamine oxidase A and B activities in heavy smokers.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Blood Platelets; Blood Pressure; Cotinine; Depression; | 1995 |
39 other studies available for 3,4-dihydroxyphenylacetic acid and Depression
| Article | Year |
|---|---|
Antidepressant activity of Spathodea campanulata in mice and predictive affinity of spatheosides towards type A monoamine oxidase.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents; Bignoniaceae; Binding, Competitive; | 2021 |
Physical exercise prevents behavioral alterations in a reserpine-treated zebrafish: A putative depression model.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents; Behavior, Animal; COVID-19; Depressi | 2022 |
[Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents; Chromatography, Liquid; Depression; | 2022 |
Prenatal SAMe Treatment Induces Changes in Brain Monoamines and in the Expression of Genes Related to Monoamine Metabolism in a Mouse Model of Social Hierarchy and Depression, Probably via an Epigenetic Mechanism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Catecholamines; Depression; Dop | 2022 |
1-Methyl-1,2,3,4-tetrahydroisoquinoline - The toxicological research on an exo/endogenous amine with antidepressant-like activity - In vivo, in vitro and in silico studies.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amines; Animals; Antidepressive Agents; Brain; Depression; Depressiv | 2019 |
Depressive-like behaviors in mice with Imiquimod-induced psoriasis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; | 2020 |
Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Antidepressive Agents; Anxiety; Behav | 2021 |
Behavioral abnormalities and reduced norepinephrine in EP4 receptor-associated protein (EPRAP)-deficient mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, An | 2017 |
Antidepressant-Like Effect of the Endogenous Neuroprotective Amine, 1MeTIQ in Clonidine-Induced Depression: Behavioral and Neurochemical Studies in Rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Biogenic Monoamines; Brain; Brain Che | 2017 |
Effects of Fluorencarbonic Acid Derivative on the Levels of Monoamines and Their Metabolites in Brain Structures of Rats with Modeled Depression-Like State.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Chromatography, High Pressure L | 2017 |
Curcumin restores rotenone induced depressive-like symptoms in animal model of neurotoxicity: assessment by social interaction test and sucrose preference test.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Choice Behavior; Corpus Striatum; Curcumi | 2019 |
The neuroactive potential of the human gut microbiota in quality of life and depression.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Bacteria; Cohort Studies; Depression; Dopamine; Feces; Female | 2019 |
Dopamine and serotonin signaling during two sensitive developmental periods differentially impact adult aggressive and affective behaviors in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Affect; Aggression; Amphetamine; Animals; Anxiety; Brain; Central Ne | 2014 |
Differential susceptibility to extinction-induced despair and age-dependent alterations in the hypothalamic-pituitary-adrenal axis and neurochemical parameters.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Behavior, Animal; Biomarkers; Depression; Dopamine; | 2008 |
Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Arousal; Body Temperature Regulation; Brain; Cerebral Corte | 2011 |
Co-involvement of psychological and neurological abnormalities in infertility with polycystic ovarian syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anxiety; Checklist; Depression; Diagnostic Self Evaluation; Dopamine | 2011 |
Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antidepressive Agents, Second-Generat | 2012 |
Neurochemical consequence of steroid abuse: stanozolol-induced monoaminergic changes.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Depression; Dopamine; Hippocampus; Homovan | 2012 |
Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liqu | 2013 |
Influence of aging and social isolation on changes in brain monoamine turnover and biosynthesis of rats elicited by novelty stress.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Biogenic Monoamines; Brain; Chromatography, High Pre | 2002 |
Monoamine metabolism changes following the mouse forced swimming test but not the tail suspension test.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Chromatography, High Pressure L | 2003 |
[Effects of Guanyu capsule on the behavior and cerebral cortex monoamine neurotransmitters in depressive model of olfactory bulb damage rats].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Biogenic Monoamines; Cerebral Cortex; Cur | 2005 |
Olfactory bulbectomy in mice leads to increased BDNF levels and decreased serotonin turnover in depression-related brain areas.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Brain-Deriv | 2007 |
[Metabolism of peripheral catecholamines and indole amines in healthy persons. Clinico-biochemical correlates].
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Carboxylic Acids; Catecholamines; Depression; Female; Glycols | 1981 |
Monoamine metabolites in human cerebrospinal fluid. HPLC/ED method.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alzheimer Disease; Chromatography, High Pressure Liquid; Depression; | 1984 |
Metabolism of (-) deprenyl to amphetamine and methamphetamine may be responsible for deprenyl's therapeutic benefit: a biochemical assessment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Amphetamines; Biogenic Amines; Carbidopa; Depression; Drug Co | 1982 |
CSF monoamine metabolites in depression and schizophrenia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Mal | 1980 |
Depletion of mesolimbic dopamine during behavioral despair: partial reversal by chronic imipramine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Depression; Disease Models, Animal; Dopami | 1993 |
Biochemical correlates of in vivo cell-mediated immune dysfunction in patients with depression: a preliminary report.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Depression; Epinephrine; Female; Humans; Hydrocortisone | 1995 |
Reduced dopamine turnover in the basal ganglia of depressed suicides.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Adult; Aged; Antidepressive Agents; Basal Ganglia; Chrom | 1997 |
Effect of reserpine on 3-methoxy-4-hydroxyphenylethyleneglycol and 3,4-dihydroxyphenylacetic acid in the hippocampus of depression-model rats: an in vivo microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Depression; Female; Hippocampus; Kinetics; Methoxyhydroxyph | 1998 |
Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Cortico | 1999 |
Increased septal 5-HIAA efflux in rats that do not develop learned helplessness after inescapable stress.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Depression; Dopamine; Helplessness, Learned; Hydroxyindolea | 2000 |
Limbic dopaminergic adaptation to a stressful stimulus in a rat model of depression.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adaptation, Physiological; Animals; Depression; Disease Models, Anim | 2001 |
Opposite genotype-dependent mesocorticolimbic dopamine response to stress.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Depression; Disease Models, Animal; Dopam | 2001 |
Chronic desipramine treatment selectively potentiates somatostatin-induced dopamine release in the nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents, Tricyclic; Depression; Desipramine; | 2001 |
Attenuating effects of the isolated rearing condition on increased brain serotonin and dopamine turnover elicited by novelty stress.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Depression; Dopamine; Exploratory Behavior; Homovani | 2002 |
Repertory grid and biochemical characterization of depression: a comparison of case reports.
Topics: 3,4-Dihydroxyphenylacetic Acid; Depression; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic | 1979 |
Differences in lithium effects in depressed and healthy subjects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Depression; Dopamine; Homovanillic Acid; Humans; Hydroxyindol | 1985 |