3,4-dihydroxyphenylacetic acid has been researched along with Brain Ischemia in 38 studies
3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.
(3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Excerpt | Relevance | Reference |
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"The possible neuroprotector effects of pentoxifylline (P), a methylxanthine derivative and phosphodiesterase inhibitor, were studied on male Wistar rats subjected to a model of transient brain ischemia." | 7.75 | Pentoxifylline treatment improves neurological and neurochemical deficits in rats subjected to transient brain ischemia. ( Batista, TM; Bruno, Rde B; Cunha, GM; de Arruda, KG; Lima, JC; Lima, PF; Marques, TF; Santos, Nda S; Viana, GS; Vitor, HV, 2009) |
"The effects of clorgyline, the MAO-A inhibitor, and lazabemide, the MAO-B inhibitor, on the levels of the hydroxyl radicals appearing in the cerebral ventricles of mice during brain ischemia/reperfusion were examined by using a salicylate trapping method." | 7.69 | MAO inhibitors, clorgyline and lazabemide, prevent hydroxyl radical generation caused by brain ischemia/reperfusion in mice. ( Akaike, N; Himori, N; Suzuki, T; Tanaka, Y; Ueno, K, 1995) |
"Valproic acid (VA) is an antiepileptic that is also used for the treatment of bipolar disorders." | 5.48 | Neuroprotective effects of valproic acid on brain ischemia are related to its HDAC and GSK3 inhibitions. ( Correia, AO; Costa, RO; da Silva Ribeiro, AE; de Barros Viana, GS; de Siqueira, KP; Dos Santos, GCA; Lima, DGS; Lucetti, DL; Lucetti, ECP; Moura, JA; Neves, KRT; Parente, LLT; Silva, MR, 2018) |
"In rats with cerebral ischemia, a low dose (10 mg/kg, i." | 5.27 | Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia. ( Kakihana, M; Nagai, Y; Nagaoka, A; Nagawa, Y; Narumi, S; Yamazaki, N, 1985) |
"The possible neuroprotector effects of pentoxifylline (P), a methylxanthine derivative and phosphodiesterase inhibitor, were studied on male Wistar rats subjected to a model of transient brain ischemia." | 3.75 | Pentoxifylline treatment improves neurological and neurochemical deficits in rats subjected to transient brain ischemia. ( Batista, TM; Bruno, Rde B; Cunha, GM; de Arruda, KG; Lima, JC; Lima, PF; Marques, TF; Santos, Nda S; Viana, GS; Vitor, HV, 2009) |
"The effects of clorgyline, the MAO-A inhibitor, and lazabemide, the MAO-B inhibitor, on the levels of the hydroxyl radicals appearing in the cerebral ventricles of mice during brain ischemia/reperfusion were examined by using a salicylate trapping method." | 3.69 | MAO inhibitors, clorgyline and lazabemide, prevent hydroxyl radical generation caused by brain ischemia/reperfusion in mice. ( Akaike, N; Himori, N; Suzuki, T; Tanaka, Y; Ueno, K, 1995) |
"During 30 minutes of global forebrain ischemia in rats, striatal intracellular levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) increase at the same time extracellular levels, measured by microdialysis, decrease." | 3.69 | Ischemia increases tissue and decreases extracellular levels of acid dopamine metabolites in the rat striatum: further evidence for active transport of metabolites. ( Clemens, JA; Mincy, RE; Phebus, LA, 1995) |
"The effect of omega-conotoxin GVIA (CgTX), an N-and L-type voltage-sensitive calcium channel (VSCC) blocker, on the release of dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum before and during transient cerebral ischemia in spontaneously hypertensive rats was studied using an in vivo brain dialysis technique." | 3.68 | Inhibition of ischemia-induced dopamine release by omega-conotoxin, a calcium channel blocker, in the striatum of spontaneously hypertensive rats: in vivo brain dialysis study. ( Fujishima, M; Nakahara, T; Ooboshi, H; Sadoshima, S; Uchimura, H; Yao, H, 1992) |
"Rat striatal extracellular fluid levels of dopamine, serotonin, 3-methoxytyramine (3-MT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were measured before, during and after transient, global cerebral ischemia in awake rats using in vivo brain microdialysis." | 3.67 | Effects of transient, global, cerebral ischemia on striatal extracellular dopamine, serotonin and their metabolites. ( Clemens, JA; Phebus, LA, 1989) |
"Valproic acid (VA) is an antiepileptic that is also used for the treatment of bipolar disorders." | 1.48 | Neuroprotective effects of valproic acid on brain ischemia are related to its HDAC and GSK3 inhibitions. ( Correia, AO; Costa, RO; da Silva Ribeiro, AE; de Barros Viana, GS; de Siqueira, KP; Dos Santos, GCA; Lima, DGS; Lucetti, DL; Lucetti, ECP; Moura, JA; Neves, KRT; Parente, LLT; Silva, MR, 2018) |
"Vannucci, Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage, Pediatr." | 1.30 | Anoxic and hypoxic immature rat model for measurement of monoamine using in vivo microdialysis. ( Ishida, A; Nakajima, W; Takada, G, 1999) |
"Whereas anoxia decreased extracellular 3,4-dihydroxyphenylacetic acid levels by 50%, aglycemia doubled it, and ischemia returned this aglycemia-induced enhancement to its control level." | 1.30 | Anoxia-induced dopamine release from rat striatal slices: involvement of reverse transport mechanism. ( Büyükuysal, RL; Mete, B, 1999) |
"Pretreatment with tetrodotoxin (TTX, 5 microM), (+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine hydrogen maleato (MK801, 1 microM) or muscimol (1 microM) inhibited SNP-induced increases in extracellular DA and decreases in DOPAC (TTX, complete block; MK801, 75% inhibition; muscimol, 80% inhibition)." | 1.29 | [Effect of nitric oxide on central dopaminergic neurons]. ( Nakahara, K; Shigemori, M; Tanaka, M; Yokoo, H; Yoshida, M, 1994) |
"Cerebral ischemia was induced by permanent occlusion of left middle cerebral artery." | 1.29 | GM1 reduces infarct volume after focal cerebral ischemia. ( Koga, T; Lazzaro, A; Manev, H; Schiavo, N; Seren, MS; Zanoni, R, 1994) |
" In time course and dose-response experiments with ET-1 and in comparisons with ET-3, the volume of the lesions has been determined based mainly on the disappearance of striatal nerve cells, using a computer assisted morphometrical analysis." | 1.28 | Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat. ( Agnati, LF; Cintra, A; Fuxe, K; Goiny, M; Hallström, A; Kurosawa, N; Rosén, L; Ungerstedt, U, 1992) |
"Our results indicate that during cerebral ischemia a large increase in extracellular dopamine concentration in the caudate nucleus occurs, probably as a result of energy failure of the cell membranes." | 1.27 | Striatal dopamine in acute cerebral ischemia of stroke-resistant rats. ( Kawano, T; Miyake, H; Mori, K; Tsutsumi, K, 1988) |
"In rats with cerebral ischemia, a low dose (10 mg/kg, i." | 1.27 | Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia. ( Kakihana, M; Nagai, Y; Nagaoka, A; Nagawa, Y; Narumi, S; Yamazaki, N, 1985) |
"The homovanillic acid (HVA) content was decreased significantly at 12 h after occlusion." | 1.27 | Changes in the content of dopamine and its metabolites in the basal ganglia following right middle cerebral artery occlusion and reflow in monkeys. ( Abraham, J; Cherian, R; Kuruvilla, A; Theodore, D, 1987) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 12 (31.58) | 18.7374 |
1990's | 20 (52.63) | 18.2507 |
2000's | 5 (13.16) | 29.6817 |
2010's | 1 (2.63) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Silva, MR | 1 |
Correia, AO | 1 |
Dos Santos, GCA | 1 |
Parente, LLT | 1 |
de Siqueira, KP | 1 |
Lima, DGS | 1 |
Moura, JA | 1 |
da Silva Ribeiro, AE | 1 |
Costa, RO | 1 |
Lucetti, DL | 1 |
Lucetti, ECP | 1 |
Neves, KRT | 1 |
de Barros Viana, GS | 1 |
Bruno, Rde B | 1 |
Marques, TF | 1 |
Batista, TM | 1 |
Lima, JC | 1 |
de Arruda, KG | 1 |
Lima, PF | 1 |
Santos, Nda S | 1 |
Cunha, GM | 1 |
Vitor, HV | 1 |
Viana, GS | 1 |
Xu, MS | 1 |
Fang, C | 1 |
Xu, J | 1 |
Zhang, GF | 1 |
Ge, LB | 1 |
Goyagi, T | 1 |
Bhardwaj, A | 2 |
Koehler, RC | 1 |
Traystman, RJ | 1 |
Hurn, PD | 1 |
Kirsch, JR | 1 |
Mitsuyo, T | 1 |
Adachi, N | 3 |
Yorozuya, T | 1 |
Tabo, E | 1 |
Nagaro, T | 2 |
Arai, T | 3 |
Suzuki, T | 1 |
Akaike, N | 1 |
Ueno, K | 1 |
Tanaka, Y | 1 |
Himori, N | 1 |
Nakahara, K | 1 |
Yokoo, H | 1 |
Yoshida, M | 1 |
Tanaka, M | 1 |
Shigemori, M | 1 |
Strasser, A | 1 |
Yasuma, Y | 1 |
McCarron, RM | 1 |
Ishii, H | 1 |
Stanimirovic, D | 1 |
Spatz, M | 1 |
Lazzaro, A | 1 |
Seren, MS | 1 |
Koga, T | 1 |
Zanoni, R | 1 |
Schiavo, N | 1 |
Manev, H | 1 |
Ooboshi, H | 2 |
Sadoshima, S | 2 |
Ibayashi, S | 1 |
Yao, H | 2 |
Uchimura, H | 2 |
Fujishima, M | 2 |
Takagi, N | 1 |
Miyake, K | 1 |
Ohiwa, A | 1 |
Nukaga, R | 1 |
Takeo, S | 1 |
Phebus, LA | 2 |
Mincy, RE | 1 |
Clemens, JA | 2 |
Huang, XX | 1 |
Hu, D | 1 |
Qu, ZW | 1 |
Zhang, JT | 1 |
Feng, YP | 1 |
Pastuszko, P | 1 |
Wilson, DF | 1 |
Lei, B | 1 |
Nakajima, W | 1 |
Ishida, A | 1 |
Takada, G | 1 |
Büyükuysal, RL | 1 |
Mete, B | 1 |
Liu, X | 1 |
Zhu, XZ | 1 |
Lesser, JB | 1 |
Koorn, R | 1 |
Vloka, JD | 1 |
Kuroda, MM | 1 |
Thys, DM | 1 |
Terao, K | 1 |
Otsuka, R | 1 |
Luthman, J | 1 |
Lindqvist, E | 1 |
Dell'Anna, E | 1 |
Kojima, H | 1 |
Shiotani, T | 1 |
Tachizawa, H | 1 |
Olson, L | 1 |
Fuxe, K | 1 |
Kurosawa, N | 1 |
Cintra, A | 1 |
Hallström, A | 1 |
Goiny, M | 1 |
Rosén, L | 1 |
Agnati, LF | 1 |
Ungerstedt, U | 1 |
Heyes, MP | 1 |
Nowak, TS | 1 |
Bao, WL | 1 |
Sun, FY | 1 |
Tong, JF | 1 |
Zhang, LM | 1 |
Zhang, AZ | 1 |
Nakahara, T | 1 |
Brannan, T | 1 |
Weinberger, J | 3 |
Nieves-Rosa, J | 1 |
Ogura, K | 2 |
Shibuya, M | 2 |
Kanamori, M | 2 |
Suzuki, Y | 2 |
Harada, T | 1 |
Okada, T | 1 |
Tanoi, C | 1 |
Kageyama, N | 1 |
Kawano, T | 2 |
Miyake, H | 2 |
Tsutsumi, K | 2 |
Mori, K | 2 |
Narumi, S | 1 |
Nagai, Y | 1 |
Kakihana, M | 1 |
Yamazaki, N | 1 |
Nagaoka, A | 1 |
Nagawa, Y | 1 |
Matsumoto, T | 1 |
Obrenovitch, TP | 1 |
Sarna, GS | 1 |
Symon, L | 1 |
Ikegaki, I | 1 |
Oishi, R | 1 |
Itoh, Y | 1 |
Nishibori, M | 1 |
Watanabe, T | 1 |
Nishi, H | 1 |
Saeki, K | 1 |
Slivka, A | 1 |
Brannan, TS | 1 |
Knott, PJ | 1 |
Cohen, G | 1 |
Kuruvilla, A | 2 |
Cherian, R | 2 |
Theodore, D | 1 |
Abraham, J | 2 |
Theodore, DR | 1 |
38 other studies available for 3,4-dihydroxyphenylacetic acid and Brain Ischemia
Article | Year |
---|---|
Neuroprotective effects of valproic acid on brain ischemia are related to its HDAC and GSK3 inhibitions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Ischemia; Cyclooxygenase 2 Inhibitors; Dopamin | 2018 |
Pentoxifylline treatment improves neurological and neurochemical deficits in rats subjected to transient brain ischemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Avoidance Learning; Brain; Brain Ischemia; Cognition; Dopam | 2009 |
[Dynamic changes of dopamine and its metabolite levels in the rat striatum after cerebral ischemia-reperfusion and electroacupuncture].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Dopamine; Electroacupuncture; Extracellular | 2009 |
Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Gas Analysis; Body Temperature; Brain Chemistry; Brai | 2003 |
Facilitation of ischemia-induced release of dopamine and neuronal damage by dexamethasone in the rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Cortex Hormones; Animals; Biogenic Monoamines; Blood Pressur | 2003 |
MAO inhibitors, clorgyline and lazabemide, prevent hydroxyl radical generation caused by brain ischemia/reperfusion in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Clorgyline; Dopamine; Hydroxyl Radical; Mal | 1995 |
[Effect of nitric oxide on central dopaminergic neurons].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Chromatography, High Pressure Liquid; Corpu | 1994 |
Effect of nitro-L-arginine on cerebral blood flow and monoamine metabolism during ischemia/reperfusion in the mongolian gerbil.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Arginine; Biogenic Monoamines; Body T | 1994 |
GM1 reduces infarct volume after focal cerebral ischemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Edema; Brain Ischemia; Caudate Nucleus; Cerebral Infa | 1994 |
Isradipine attenuates the ischemia-induced release of dopamine in the striatum of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Gas Analysis; Brain Ischemia; Cerebrovascular Circula | 1993 |
Effects of delayed treatment with nafronyl oxalate on microsphere embolism-induced changes in monoamine levels of rat brain regions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Brain Ischemia; Dopamine; Hydro | 1996 |
Ischemia increases tissue and decreases extracellular levels of acid dopamine metabolites in the rat striatum: further evidence for active transport of metabolites.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biological Transport, Active; Brain Ischemia; Corpus Striat | 1995 |
[Effect of dl-3-butylphthalide on the striatum extracellular amino acid and dopamine contents in the rat during cerebral ischemia].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzofurans; Brain Ischemia; Corpus Striatum; Dopamine; Ext | 1996 |
Activation of tyrosine hydroxylase in striatum of newborn piglets in response to hypocapnic ischemia and recovery.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Brain Ischemia; Corpus Striatum; Dihydrox | 1997 |
The effect of dopamine depletion on the H2O2 production in the rat striatum following transient middle cerebral artery occlusion.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Cerebral Arteries; Dopamine; Homovanillic A | 1997 |
Anoxic and hypoxic immature rat model for measurement of monoamine using in vivo microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Brain; Brain Chemistry; Brain Ischemia; C | 1999 |
Anoxia-induced dopamine release from rat striatal slices: involvement of reverse transport mechanism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biological Transport; Brain Ischemia; Corpus Striatum; Dizo | 1999 |
Basic fibroblast growth factor protected forebrain against ischemia-reperfusion damage in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Corpus Striatum; Dopamine; Female; Fibrobla | 1998 |
The interaction of temperature with thiopental and etomidate on extracellular dopamine and glutamate levels in Wistar-Kyoto rats subjected to forebrain ischemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anesthetics, Intravenous; Animals; Blood Pressure; Brain Ischemia; C | 1999 |
Histaminergic H(2) blockade facilitates ischemic release of dopamine in gerbil striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Corpus Striatum; Dopamine; Gerbillinae; His | 2002 |
Effects of DM-9384, a pyrrolidone derivative, on ischemia-induced changes in the central monoamine systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain Chemistry; Brain Ischemia; Centr | 1992 |
Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Cerebrovascular Circulation; Corpus Striatu | 1992 |
Delayed increases in regional brain quinolinic acid follow transient ischemia in the gerbil.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Dopamin | 1990 |
[Antagonistic effect of phencyclidine on cerebral ischemic damage of rats].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Ischemia; Catecholamines; Cerebral Cortex; Dop | 1991 |
Inhibition of ischemia-induced dopamine release by omega-conotoxin, a calcium channel blocker, in the striatum of spontaneously hypertensive rats: in vivo brain dialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Calcium Channel Blockers; Dialysis; Dopamin | 1992 |
Pentobarbital inhibits extracellular release of dopamine in the ischemic striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Corpus Striatum; Depression, Chemical; Dopa | 1990 |
Metabolism of monoamine neurotransmitters in the evolution of infarction in ischemic striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Brain Ischemia; Carotid Arteries; Cerebral | 1987 |
[Measurements of monoamine neurotransmitter metabolism by in vivo voltammetry].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Brain; Brain Ischemia; Dopamine; Electrodi | 1987 |
[Sequential changes in dopamine and monoamine metabolites in ischemic rat caudate nucleus. In vivo dialysis coupled with high-performance liquid chromatography with electrochemical detection].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Brain Ischemia; Caudate Nucleus; Chromatog | 1988 |
Striatal dopamine in acute cerebral ischemia of stroke-resistant rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Caudate Nucleus; Cerebrovascular Disorders; | 1988 |
Effects of transient, global, cerebral ischemia on striatal extracellular dopamine, serotonin and their metabolites.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Corpus Striatum; Dopamine; Extracellular Sp | 1989 |
Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzoquinones; Biogenic Amines; Brain; Brain Ischemia; Chro | 1985 |
[Extracellular concentration of dopamine and dopamine metabolites in the rat striatum during cerebral ischemia and reperfusion].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Chromatography, High Pressure Liquid; Corpu | 1989 |
Changes in striatal dopamine metabolism measured by in vivo voltammetry during transient brain ischemia in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulatio | 1989 |
Effect of MCI-186 on ischemia-induced changes in monoamine metabolism in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipyrine; Biogenic Monoamines; Brain; Brain Edema; Brain | 1989 |
Increase in extracellular dopamine in the striatum during cerebral ischemia: a study utilizing cerebral microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Ischemia; Carotid Arteries; Corpus Striatum; Dialysis | 1988 |
Changes in the content of dopamine and its metabolites in the basal ganglia following right middle cerebral artery occlusion and reflow in monkeys.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Basal Ganglia; Brain Ischemia; Cerebral Arteries; Constrict | 1987 |
Temporal profile of tissue levels of dopamine and its metabolites, HVA and DOPAC following focal cerebral ischaemia in anaesthetized primates.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Basal Ganglia; Brain Ischemia; Dopamine; Female; Homovanill | 1986 |