Compounds > 3-4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2h)-isoquinolinone

3-4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2h)-isoquinolinone and Parkinson-Disease

3-4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2h)-isoquinolinone has been researched along with Parkinson-Disease* in 1 studies

Other Studies

1 other study(ies) available for 3-4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2h)-isoquinolinone and Parkinson-Disease

Article	Year
Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation. Cell death and differentiation, 2017, Volume: 24, Issue:1 The Parkinson's disease (PD)-related protein F-box only protein 7 (Fbxo7) is the substrate-recognition component of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex. We have recently shown that PD-associated mutations in Fbxo7 disrupt mitochondrial autophagy (mitophagy), suggesting a role for Fbxo7 in modulating mitochondrial homeostasis. Here we report that Fbxo7 deficiency is associated with reduced cellular NAD Topics: Adenosine Triphosphate; Cells, Cultured; Electron Transport Complex I; F-Box Proteins; Humans; Iodoacetic Acid; Isoquinolines; Membrane Potential, Mitochondrial; Mitochondria; Mitophagy; NAD; Oxygen Consumption; Parkinson Disease; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Polymorphism, Single Nucleotide; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sodium Cyanide	2017

Article

Year

Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation.

Cell death and differentiation, 2017, Volume: 24, Issue:1

The Parkinson's disease (PD)-related protein F-box only protein 7 (Fbxo7) is the substrate-recognition component of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex. We have recently shown that PD-associated mutations in Fbxo7 disrupt mitochondrial autophagy (mitophagy), suggesting a role for Fbxo7 in modulating mitochondrial homeostasis. Here we report that Fbxo7 deficiency is associated with reduced cellular NAD

Topics: Adenosine Triphosphate; Cells, Cultured; Electron Transport Complex I; F-Box Proteins; Humans; Iodoacetic Acid; Isoquinolines; Membrane Potential, Mitochondrial; Mitochondria; Mitophagy; NAD; Oxygen Consumption; Parkinson Disease; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Polymorphism, Single Nucleotide; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sodium Cyanide

2017