3-4-dicarboxyphenylglycine and Epilepsy--Tonic-Clonic

3-4-dicarboxyphenylglycine has been researched along with Epilepsy--Tonic-Clonic* in 1 studies

Other Studies

1 other study(ies) available for 3-4-dicarboxyphenylglycine and Epilepsy--Tonic-Clonic

Article	Year
Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology, 2001, Volume: 40, Issue:5 The 3,4-dicarboxyphenylglycines (3,4-DCPG) inhibit sound-induced seizures in DBA/2 mice with the racemate being notably more potent than either isomer (ED(50) (nmol, i.c.v.)): (RS)-3,4-DCPG (0.004; 86 mg/kg, i.p.)>>the mGlu(8) agonist (S)-3,4-DCPG (0.11)>the AMPA antagonist (R)-3,4-DCPG (0.38). A potentiation of anticonvulsant activity between AMPA and mGlu(8) receptors was confirmed by combining (R)-3,4-DCPG with the mGlu(8) agonist (RS)-4-phosphonophenylglycine. This potentiating mechanism provides a novel strategy for the treatment of epileptic seizures. Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzoates; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Antagonists; Female; Glycine; Male; Mice; Mice, Inbred DBA; Receptors, AMPA; Receptors, Metabotropic Glutamate; Stereoisomerism	2001

Article

Year

Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice.

Neuropharmacology, 2001, Volume: 40, Issue:5

The 3,4-dicarboxyphenylglycines (3,4-DCPG) inhibit sound-induced seizures in DBA/2 mice with the racemate being notably more potent than either isomer (ED(50) (nmol, i.c.v.)): (RS)-3,4-DCPG (0.004; 86 mg/kg, i.p.)>>the mGlu(8) agonist (S)-3,4-DCPG (0.11)>the AMPA antagonist (R)-3,4-DCPG (0.38). A potentiation of anticonvulsant activity between AMPA and mGlu(8) receptors was confirmed by combining (R)-3,4-DCPG with the mGlu(8) agonist (RS)-4-phosphonophenylglycine. This potentiating mechanism provides a novel strategy for the treatment of epileptic seizures.

Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzoates; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Antagonists; Female; Glycine; Male; Mice; Mice, Inbred DBA; Receptors, AMPA; Receptors, Metabotropic Glutamate; Stereoisomerism

2001