Compounds > 3-4-di-o-caffeoylquinic-acid

3-4-di-o-caffeoylquinic-acid and Fatty-Liver

3-4-di-o-caffeoylquinic-acid has been researched along with Fatty-Liver* in 1 studies

Other Studies

1 other study(ies) available for 3-4-di-o-caffeoylquinic-acid and Fatty-Liver

Article	Year
In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid. Journal of medicinal food, 2005,Fall, Volume: 8, Issue:3 Pretreatment with a methanolic extract of Ligularia fischeri var. spiciformis (Compositae) herb inhibited hepatotoxicities caused by CCl4, D-galactosamine (GalN), alpha-naphthylisothiocyanate (ANIT), and DL-ethionine in rats. An ethyl acetate (EtOAc) extract fractionated from the methanolic extract showed a strong inhibitory effect. A major component, 3,4-dicaffeoylquinic acid (DCQA), isolated from the methanolic extract was examined for antihepatotoxicity. Pretreatment with DCQA (5 and 10 mg/kg, p.o.) significantly reduced serum aminotransferases (alanine and aspartate), sorbitol dehydrogenase, gamma-glutamyltransferase, alkaline phosphatase, and lactate dehydrogenase activities during CCl4- or GalN-induced hepatotoxicity, suggesting that DCQA is a major principle for the antihepatotoxic activity of L. fischeri var. spiciformis. DCQA also partially restored bile flow and reduced total bilirubin and cholic acid concentrations in rats with ANIT-induced cholestasis. Treatment with DCQA inhibited the increase in triglyceride, cholesterol, and total lipids in DL-ethionine-induced fatty liver. These results support the traditionally held belief that this plant can be used for the treatment of jaundice and hepatic failure. Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Asteraceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorogenic Acid; Ethionine; Fatty Liver; Galactosamine; gamma-Glutamyltransferase; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Lipids; Liver; Liver Diseases; Male; Plant Leaves; Rats; Rats, Sprague-Dawley	2005

Article

Year

In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid.

Journal of medicinal food, 2005,Fall, Volume: 8, Issue:3

Pretreatment with a methanolic extract of Ligularia fischeri var. spiciformis (Compositae) herb inhibited hepatotoxicities caused by CCl4, D-galactosamine (GalN), alpha-naphthylisothiocyanate (ANIT), and DL-ethionine in rats. An ethyl acetate (EtOAc) extract fractionated from the methanolic extract showed a strong inhibitory effect. A major component, 3,4-dicaffeoylquinic acid (DCQA), isolated from the methanolic extract was examined for antihepatotoxicity. Pretreatment with DCQA (5 and 10 mg/kg, p.o.) significantly reduced serum aminotransferases (alanine and aspartate), sorbitol dehydrogenase, gamma-glutamyltransferase, alkaline phosphatase, and lactate dehydrogenase activities during CCl4- or GalN-induced hepatotoxicity, suggesting that DCQA is a major principle for the antihepatotoxic activity of L. fischeri var. spiciformis. DCQA also partially restored bile flow and reduced total bilirubin and cholic acid concentrations in rats with ANIT-induced cholestasis. Treatment with DCQA inhibited the increase in triglyceride, cholesterol, and total lipids in DL-ethionine-induced fatty liver. These results support the traditionally held belief that this plant can be used for the treatment of jaundice and hepatic failure.

Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Asteraceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorogenic Acid; Ethionine; Fatty Liver; Galactosamine; gamma-Glutamyltransferase; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Lipids; Liver; Liver Diseases; Male; Plant Leaves; Rats; Rats, Sprague-Dawley

2005