3-4-5-trihydroxybenzamidoxime has been researched along with Leukemia-P388* in 1 studies
1 other study(ies) available for 3-4-5-trihydroxybenzamidoxime and Leukemia-P388
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Potentiation of the activity of cisplatin and cyclophosphamide by trimidox, a novel ribonucleotide reductase inhibitor, in leukemia-bearing mice.
We describe the use of the new ribonucleotide reductase inhibitor, trimidox (TDX), in combination chemotherapy under in vitro and in vivo conditions with cisplatin and cyclophosphamide. In vitro, the combination of TDX and cisplatin was tested in L1210 cells. The combination caused concentration dependent antagonistic or additive effects. However, the combination of TDX-cisplatin-cyclophosphamide in vivo is highly synergistic in both, the L1210 and P388D1 leukemia mouse models. Both combinations, TDX with cisplatin or TDX with cyclophosphamide were also synergistic in the L1210 and P388D1 leukemia animal models. Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamidines; Cisplatin; Cyclophosphamide; Drug Synergism; Enzyme Inhibitors; Leukemia L1210; Leukemia P388; Male; Mice; Mice, Inbred DBA; Ribonucleotide Reductases | 2006 |