3-4--dihydroxyflavone and Melanoma
3-4--dihydroxyflavone has been researched along with Melanoma* in 1 studies
Other Studies
1 other study(ies) available for 3-4--dihydroxyflavone and Melanoma
Article | Year |
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3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells.
Flavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. A series of flavonols and their 3-methyl ether derivatives were synthesized and assessed for cytotoxicity. It was found that 3'-hydroxy-3,4'-dimethoxyflavone (flavonoid 7a) displayed strong cytotoxicity against human SK-MEL-1 melanoma cells and blocked tubulin polymerization, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. Our analyses showed that flavonoid 7a induces G Topics: Apoptosis; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flavones; Humans; Melanoma; Microscopy, Fluorescence; Molecular Structure; Polymerization; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured | 2017 |