3,3'-diindolylmethane has been researched along with Neoplasms in 9 studies
3,3'-diindolylmethane: anti-inflammatory from edible cruciferous vegetables; a cytochrome P-450 antagonist
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The landscape of cancer has changed considerably in past several years, due mainly to aggressive screening, accumulation of data from basic and epidemiological studies, and the advances in translational research." | 2.53 | The bounty of nature for changing the cancer landscape. ( Ahmad, A; Li, Y; Sarkar, FH, 2016) |
| "The hallmarks of EMT in cancer cells include changed cell morphology and increased metastatic capabilities in cell migration and invasion." | 2.53 | Roles of Dietary Phytoestrogens on the Regulation of Epithelial-Mesenchymal Transition in Diverse Cancer Metastasis. ( Choi, KC; Hwang, KA; Lee, GA, 2016) |
| "The antioxidative and anticancer effects of these natural agents make them strong candidates for chemoprevention and/or therapy against human malignancies." | 2.49 | Antioxidant function of isoflavone and 3,3'-diindolylmethane: are they important for cancer prevention and therapy? ( Ahmad, A; Bao, B; Kong, D; Li, Y; Sarkar, FH, 2013) |
| " However, some of these agents have poor bioavailability and many of the in-depth studies into their mechanisms of action have been carried out in vitro using doses which are unachievable in humans." | 2.44 | Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals. ( Andreadi, CK; Foreman, BE; Howells, LM; Hudson, EA; Manson, MM; Moiseeva, EP; Neal, CP; Sun, YY, 2007) |
| "Metastasis of cancer is a multifactorial disease and is the main cause of death in patients with malignancy." | 1.37 | 3,3'-diindolylmethane inhibits migration and invasion of human cancer cells through combined suppression of ERK and AKT pathways. ( Geliebter, J; Moscatello, A; Rajoria, S; Schantz, SP; Suriano, R; Tiwari, RK; Wilson, YL, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 3 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Ahmad, A | 2 |
| Sarkar, FH | 2 |
| Fujioka, N | 1 |
| Fritz, V | 1 |
| Upadhyaya, P | 1 |
| Kassie, F | 1 |
| Hecht, SS | 1 |
| Lee, GA | 1 |
| Hwang, KA | 1 |
| Choi, KC | 1 |
| Rajoria, S | 1 |
| Suriano, R | 1 |
| Wilson, YL | 1 |
| Schantz, SP | 1 |
| Moscatello, A | 1 |
| Geliebter, J | 1 |
| Tiwari, RK | 1 |
| Kong, D | 1 |
| Bao, B | 1 |
| Minich, DM | 1 |
| Bland, JS | 1 |
| Howells, LM | 1 |
| Moiseeva, EP | 2 |
| Neal, CP | 1 |
| Foreman, BE | 1 |
| Andreadi, CK | 1 |
| Sun, YY | 1 |
| Hudson, EA | 1 |
| Manson, MM | 2 |
| Almeida, GM | 1 |
| Jones, GD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-Blinded, Placebo-Controlled Study With Immunotype Specific Dietary Supplements to Improve Inflammatory Age® by Edifice Health[NCT04983017] | 750 participants (Anticipated) | Interventional | 2021-08-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for 3,3'-diindolylmethane and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
The bounty of nature for changing the cancer landscape.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Curcumin; Dietary Supplements; Epigenesi | 2016 |
Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biomarkers; Brassicaceae; Carcinogens; Cell Line, | 2016 |
Roles of Dietary Phytoestrogens on the Regulation of Epithelial-Mesenchymal Transition in Diverse Cancer Metastasis.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Cell Line, Tumor; Epithelial-Mesenchymal Transition; | 2016 |
Antioxidant function of isoflavone and 3,3'-diindolylmethane: are they important for cancer prevention and therapy?
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Biological Factors; Humans; I | 2013 |
A review of the clinical efficacy and safety of cruciferous vegetable phytochemicals.
Topics: Anticarcinogenic Agents; Brassicaceae; Consumer Product Safety; Humans; Indoles; Neoplasms; Phytoest | 2007 |
Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Catechin | 2007 |
2 other studies available for 3,3'-diindolylmethane and Neoplasms
| Article | Year |
|---|---|
3,3'-diindolylmethane inhibits migration and invasion of human cancer cells through combined suppression of ERK and AKT pathways.
Topics: Anticarcinogenic Agents; Cell Movement; Cell Proliferation; Down-Regulation; Drug Evaluation, Precli | 2011 |
Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Catechin; Cell Cycle; Cell Line, Tu | 2007 |