3,3'-diindolylmethane has been researched along with Invasiveness, Neoplasm in 15 studies
3,3'-diindolylmethane: anti-inflammatory from edible cruciferous vegetables; a cytochrome P-450 antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although 3,3'-diindolylmethane (DIM) has been suggested to reduce the risk of colorectal cancer, the underlying biological mechanism is not clearly understood." | 7.81 | FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethane inhibits migration and invasion of human colorectal cancer cells. ( Jin, H; Kim, SM; Li, XJ; Park, MH, 2015) |
| "Late stage hepatocellular carcinoma (HCC) usually has a low survival rate because it has high potential of metastases and there is no effective cure." | 5.42 | 3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling. ( Chen, LP; Li, JT; Li, WX; Liu, HZ; Sun, MY; Zhu, W, 2015) |
| "Although 3,3'-diindolylmethane (DIM) has been suggested to reduce the risk of colorectal cancer, the underlying biological mechanism is not clearly understood." | 3.81 | FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethane inhibits migration and invasion of human colorectal cancer cells. ( Jin, H; Kim, SM; Li, XJ; Park, MH, 2015) |
| " Here we found that the phytochemical 3,3'-Diindolylmethane (DIM) can inhibit the growth and also the invasion of breast cancer, glioma, and non-small cell lung cancer cells regardless of which EGFR mutant is expressed and the drug-resistant phenotype." | 3.76 | 3,3'-Diindolylmethane (DIM) inhibits the growth and invasion of drug-resistant human cancer cells expressing EGFR mutants. ( Huang, KL; Rahimi, M; Tang, CK, 2010) |
| " 3,3'-Diindolylmethane (DIM) is an acid-catalyzed product generated during the consumption of cruciferous vegetables and appears to be chemoprotective for breast cancer." | 3.74 | CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3'-diindolylmethane for breast and ovarian cancers. ( Chen, N; Hankinson, O; Hsu, EL; Taylor, RT; Wang, F; Westbrook, A; Zhang, R, 2008) |
| "Ovarian cancer is a highly lethal gynecological malignancy for which the overall prognosis has remained poor over the past few decades." | 1.43 | IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in ovarian cancer cells. ( Xu, C; Zhang, X; Zou, M, 2016) |
| "Late stage hepatocellular carcinoma (HCC) usually has a low survival rate because it has high potential of metastases and there is no effective cure." | 1.42 | 3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling. ( Chen, LP; Li, JT; Li, WX; Liu, HZ; Sun, MY; Zhu, W, 2015) |
| "Muscle-invasive bladder cancer tissues were characterised by nuclear expression of phosphorylated STAT1, 3 and 5." | 1.39 | Inhibition of STAT signalling in bladder cancer by diindolylmethane: relevance to cell adhesion, migration and proliferation. ( Cheng, MK; Griffiths, TR; Kai, B; Kriajevska, M; Manson, MM; Mellon, JK; Sun, Y, 2013) |
| "Metastasis of cancer is a multifactorial disease and is the main cause of death in patients with malignancy." | 1.37 | 3,3'-diindolylmethane inhibits migration and invasion of human cancer cells through combined suppression of ERK and AKT pathways. ( Geliebter, J; Moscatello, A; Rajoria, S; Schantz, SP; Suriano, R; Tiwari, RK; Wilson, YL, 2011) |
| "The aggressive course of pancreatic cancer is believed to reflect its unusually invasive and metastatic nature, which is associated with epidermal growth factor receptor (EGFR) overexpression and NF-kappaB activation." | 1.36 | miR-146a suppresses invasion of pancreatic cancer cells. ( Ali, S; Kong, D; Li, Y; Philip, PA; Sarkar, FH; Vandenboom, TG; Wang, Z, 2010) |
| " We found that BioResponse DIM (B-DIM), a formulated DIM with higher bioavailability, inhibited angiogenesis and invasion by reducing the bioavailability of vascular endothelial growth factor (VEGF) via repressing extracellular matrix-degrading proteases, such as matrix metalloproteinase (MMP)-9 and urokinase-type plasminogen activator (uPA), in human prostate cancer cells and reduced vascularity (angiogenesis) in vivo using Matrigel plug assay." | 1.34 | Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. ( Banerjee, S; Kong, D; Li, Y; Sarkar, FH; Wang, Z, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Munakarmi, S | 1 |
| Shrestha, J | 1 |
| Shin, HB | 1 |
| Lee, GH | 1 |
| Jeong, YJ | 1 |
| Yu, J | 1 |
| Feng, Y | 1 |
| Wang, Y | 1 |
| An, R | 1 |
| Jin, H | 1 |
| Li, XJ | 1 |
| Park, MH | 1 |
| Kim, SM | 1 |
| Li, WX | 1 |
| Chen, LP | 1 |
| Sun, MY | 1 |
| Li, JT | 1 |
| Liu, HZ | 1 |
| Zhu, W | 1 |
| Zou, M | 1 |
| Zhang, X | 1 |
| Xu, C | 1 |
| Ahmad, A | 1 |
| Kong, D | 4 |
| Wang, Z | 4 |
| Sarkar, SH | 1 |
| Banerjee, S | 3 |
| Sarkar, FH | 4 |
| Kim, EJ | 1 |
| Shin, M | 1 |
| Park, H | 1 |
| Hong, JE | 1 |
| Shin, HK | 1 |
| Kim, J | 1 |
| Kwon, DY | 1 |
| Park, JH | 1 |
| Li, Y | 3 |
| Vandenboom, TG | 1 |
| Ali, S | 1 |
| Philip, PA | 1 |
| Rahimi, M | 1 |
| Huang, KL | 1 |
| Tang, CK | 1 |
| Rajoria, S | 1 |
| Suriano, R | 1 |
| Wilson, YL | 1 |
| Schantz, SP | 1 |
| Moscatello, A | 1 |
| Geliebter, J | 1 |
| Tiwari, RK | 1 |
| Sun, Y | 1 |
| Cheng, MK | 1 |
| Griffiths, TR | 1 |
| Mellon, JK | 1 |
| Kai, B | 1 |
| Kriajevska, M | 1 |
| Manson, MM | 1 |
| Chang, X | 1 |
| Tou, JC | 1 |
| Hong, C | 1 |
| Kim, HA | 1 |
| Riby, JE | 1 |
| Firestone, GL | 1 |
| Bjeldanes, LF | 1 |
| Huang, W | 1 |
| Kim, HR | 1 |
| Hsu, EL | 1 |
| Chen, N | 1 |
| Westbrook, A | 1 |
| Wang, F | 1 |
| Zhang, R | 1 |
| Taylor, RT | 1 |
| Hankinson, O | 1 |
15 other studies available for 3,3'-diindolylmethane and Invasiveness, Neoplasm
| Article | Year |
|---|---|
3,3'-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Carcinoma, He | 2021 |
Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12.
Topics: Cell Proliferation; Disease Progression; Down-Regulation; Gene Knockdown Techniques; Humans; Indoles | 2018 |
FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethane inhibits migration and invasion of human colorectal cancer cells.
Topics: Cadherins; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Forkhead Box Protein M1; Forkhea | 2015 |
3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Mov | 2015 |
IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in ovarian cancer cells.
Topics: Blotting, Western; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival | 2016 |
Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Gene Expressio | 2009 |
Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice.
Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Cell Adhesion; Cell Movement; Enzyme Inhibitors; | 2009 |
miR-146a suppresses invasion of pancreatic cancer cells.
Topics: Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cells, Cultured; Drug Evaluation, Preclinical; | 2010 |
3,3'-Diindolylmethane (DIM) inhibits the growth and invasion of drug-resistant human cancer cells expressing EGFR mutants.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell | 2010 |
3,3'-diindolylmethane inhibits migration and invasion of human cancer cells through combined suppression of ERK and AKT pathways.
Topics: Anticarcinogenic Agents; Cell Movement; Cell Proliferation; Down-Regulation; Drug Evaluation, Precli | 2011 |
Inhibition of STAT signalling in bladder cancer by diindolylmethane: relevance to cell adhesion, migration and proliferation.
Topics: Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Cycle; Cell Nucleus; Gene Silencing; Humans; I | 2013 |
3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice.
Topics: Angiogenesis Inhibitors; Animals; Anticarcinogenic Agents; Breast Neoplasms; Cell Movement; Cell Pro | 2005 |
Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer.
Topics: Anticarcinogenic Agents; Cell Line, Tumor; DNA, Neoplasm; Down-Regulation; Endothelial Cells; Humans | 2007 |
Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells.
Topics: Cell Growth Processes; Cell Line, Tumor; Enzyme Activation; Humans; Indoles; Lymphokines; Male; Neop | 2008 |
CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3'-diindolylmethane for breast and ovarian cancers.
Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Cattle; Cell Hypoxia; Cell Line, Tumor; Chemokin | 2008 |