3,3'-diindolylmethane has been researched along with Disease Models, Animal in 19 studies
3,3'-diindolylmethane: anti-inflammatory from edible cruciferous vegetables; a cytochrome P-450 antagonist
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we examined the effects of 17β-estradiol (E2), two endocrine disrupting chemicals (EDCs), triclosan (TCS) and bisphenol A (BPA), and DIM on epithelial-mesenchymal transition (EMT) and metastatic behaviors of estrogen receptor (ER)-positive MCF-7 breast cancer cells." | 7.85 | Inhibitory effects of 3,3'-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer. ( Choi, KC; Hwang, KA; Lee, GA, 2017) |
| " In this study, we examined the beneficial effects of 3,3'-diindolylmethane (DIM) and indole-3-carbinol (I3C), dietary components found in cruciferous vegetables, on brain inflammation." | 7.80 | 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation. ( Choi, BR; Han, JS; Kim, HW; Kim, J; Lee, HJ; Lee, KW; Lee, S, 2014) |
| "DIM induces apoptosis in prostate cancer cells via the mitochondria- and death receptor-mediated pathways." | 5.37 | 3,3'-Diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model. ( Cho, HJ; Kim, EJ; Kim, JK; Park, JH; Park, SY, 2011) |
| " In this study, we examined the effects of 17β-estradiol (E2), two endocrine disrupting chemicals (EDCs), triclosan (TCS) and bisphenol A (BPA), and DIM on epithelial-mesenchymal transition (EMT) and metastatic behaviors of estrogen receptor (ER)-positive MCF-7 breast cancer cells." | 3.85 | Inhibitory effects of 3,3'-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer. ( Choi, KC; Hwang, KA; Lee, GA, 2017) |
| " In this study, we examined the beneficial effects of 3,3'-diindolylmethane (DIM) and indole-3-carbinol (I3C), dietary components found in cruciferous vegetables, on brain inflammation." | 3.80 | 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation. ( Choi, BR; Han, JS; Kim, HW; Kim, J; Lee, HJ; Lee, KW; Lee, S, 2014) |
| "To determine if DIM has an antiinflammatory effect in vivo, we examined the therapeutic effects of DIM in dextran sodium sulfate (DSS)-induced experimental colitis and colitis-associated colon carcinogenesis induced by azoxymethane (AOM)/DSS in BALB/c mice." | 3.75 | 3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. ( Kang, YH; Kim, DH; Kim, JK; Kim, YH; Kwon, HS; Park, JH; Shin, EK; Shin, HK, 2009) |
| "Psoriasis is a highly inflammatory autoimmune-mediated skin disease." | 1.72 | 3, 3'- diindolylmethane hinders IL-17A/IL-17RA interaction and mitigates imiquimod-induced psoriasiform in mice. ( Rasool, M; Srikanth, M, 2022) |
| "Atopic dermatitis is a severe, chronic relapsing inflammatory disease of the skin with family clustering." | 1.62 | 3,3'-Diindolylmethane alleviates acute atopic dermatitis by regulating T cell differentiation in a mouse model. ( Chen, C; Chen, J; Ding, Z; Dong, L; Huang, Z; Liu, J; Wu, X; Zang, Y; Zhang, J, 2021) |
| "Six human ovarian cancer cell lines and an ovarian tumor xenograft animal model were used to study the effect of diindolylmethane alone or in combination with cisplatin." | 1.38 | Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3). ( Kandala, PK; Srivastava, SK, 2012) |
| "DIM induces apoptosis in prostate cancer cells via the mitochondria- and death receptor-mediated pathways." | 1.37 | 3,3'-Diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model. ( Cho, HJ; Kim, EJ; Kim, JK; Park, JH; Park, SY, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 13 (68.42) | 24.3611 |
| 2020's | 5 (26.32) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ramakrishna, K | 1 |
| Singh, N | 1 |
| Krishnamurthy, S | 1 |
| Madison, CA | 1 |
| Kuempel, J | 1 |
| Albrecht, GL | 1 |
| Hillbrick, L | 1 |
| Jayaraman, A | 1 |
| Safe, S | 1 |
| Chapkin, RS | 1 |
| Eitan, S | 1 |
| Srikanth, M | 1 |
| Rasool, M | 1 |
| Wu, X | 1 |
| Liu, J | 1 |
| Chen, C | 1 |
| Huang, Z | 2 |
| Zang, Y | 1 |
| Chen, J | 2 |
| Dong, L | 2 |
| Zhang, J | 2 |
| Ding, Z | 1 |
| Shi, H | 1 |
| Xu, X | 1 |
| Zhang, B | 1 |
| Xu, J | 1 |
| Pan, Z | 1 |
| Gong, A | 1 |
| Zhang, X | 1 |
| Li, R | 1 |
| Sun, Y | 1 |
| Yan, Y | 1 |
| Mao, F | 1 |
| Qian, H | 1 |
| Xu, W | 1 |
| Lee, GA | 1 |
| Hwang, KA | 1 |
| Choi, KC | 1 |
| Kim, JY | 1 |
| Le, TAN | 1 |
| Lee, SY | 1 |
| Song, DG | 1 |
| Hong, SC | 1 |
| Cha, KH | 1 |
| Lee, JW | 1 |
| Pan, CH | 1 |
| Kang, K | 1 |
| Kim, HW | 1 |
| Kim, J | 2 |
| Lee, S | 1 |
| Choi, BR | 1 |
| Han, JS | 1 |
| Lee, KW | 1 |
| Lee, HJ | 1 |
| Kiselev, VI | 1 |
| Drukh, VM | 1 |
| Muyzhnek, EL | 1 |
| Kuznetsov, IN | 1 |
| Pchelintseva, OI | 1 |
| Paltsev, MA | 1 |
| Song, JM | 1 |
| Qian, X | 1 |
| Teferi, F | 1 |
| Pan, J | 1 |
| Wang, Y | 1 |
| Kassie, F | 2 |
| Deng, W | 1 |
| Zong, J | 1 |
| Wei, L | 1 |
| Guo, H | 1 |
| Cheng, Z | 1 |
| Zhang, R | 1 |
| Lin, Y | 1 |
| Tang, Q | 1 |
| Femia, AP | 1 |
| Soares, PV | 1 |
| Luceri, C | 1 |
| Lodovici, M | 1 |
| Giannini, A | 1 |
| Caderni, G | 1 |
| Fujioka, N | 1 |
| Fritz, V | 1 |
| Upadhyaya, P | 1 |
| Hecht, SS | 1 |
| Kim, YH | 1 |
| Kwon, HS | 1 |
| Kim, DH | 1 |
| Shin, EK | 1 |
| Kang, YH | 1 |
| Park, JH | 2 |
| Shin, HK | 1 |
| Kim, JK | 2 |
| Ali, S | 1 |
| Banerjee, S | 1 |
| Schaffert, JM | 1 |
| El-Rayes, BF | 1 |
| Philip, PA | 1 |
| Sarkar, FH | 1 |
| Cho, HJ | 1 |
| Park, SY | 1 |
| Kim, EJ | 1 |
| Kandala, PK | 1 |
| Srivastava, SK | 1 |
| Jiang, Y | 1 |
| Yang, Y | 1 |
| Shao, J | 1 |
| Sun, X | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-Blinded, Placebo-Controlled Study With Immunotype Specific Dietary Supplements to Improve Inflammatory Age® by Edifice Health[NCT04983017] | 750 participants (Anticipated) | Interventional | 2021-08-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 3,3'-diindolylmethane and Disease Models, Animal
| Article | Year |
|---|---|
Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biomarkers; Brassicaceae; Carcinogens; Cell Line, | 2016 |
18 other studies available for 3,3'-diindolylmethane and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Diindolylmethane ameliorates platelet aggregation and thrombosis: In silico, in vitro, and in vivo studies.
Topics: Animals; Blood Coagulation; Disease Models, Animal; Fibrinolytic Agents; Humans; Indoles; Male; Plat | 2022 |
3,3'-Diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice.
Topics: Anhedonia; Animals; Antidepressive Agents; Disease Models, Animal; Female; Humans; Indoles; Ligands; | 2022 |
3, 3'- diindolylmethane hinders IL-17A/IL-17RA interaction and mitigates imiquimod-induced psoriasiform in mice.
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Indoles; Interleukin-17; Janus Kinases; Kera | 2022 |
3,3'-Diindolylmethane alleviates acute atopic dermatitis by regulating T cell differentiation in a mouse model.
Topics: Acute Disease; Adult; Animals; Cell Differentiation; Cells, Cultured; Dermatitis, Atopic; Disease Mo | 2021 |
3,3'-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing.
Topics: Animals; Burns; Cells, Cultured; Disease Models, Animal; Humans; Indoles; Mesenchymal Stem Cells; Ra | 2017 |
Inhibitory effects of 3,3'-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer.
Topics: Animals; Benzhydryl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation | 2017 |
3,3'-Diindolylmethane Improves Intestinal Permeability Dysfunction in Cultured Human Intestinal Cells and the Model Animal
Topics: Animals; Caco-2 Cells; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Anim | 2019 |
3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antigens, Differentiation; Calcium-Binding Proteins; Cell Death; | 2014 |
Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship | 2014 |
Dietary diindolylmethane suppresses inflammation-driven lung squamous cell carcinoma in mice.
Topics: Animals; Carcinoma, Squamous Cell; Carmustine; Cytokines; Diet; Disease Models, Animal; Female; Gene | 2015 |
3,3'-Diindolylmethane improves myocardial energy metabolism imbalance induced by pressure overload via AMPKα in mice.
Topics: AMP-Activated Protein Kinases; Animals; Anticarcinogenic Agents; Disease Models, Animal; Energy Meta | 2014 |
Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Chemoprevention; Colonic Neoplasms; Curcumin; Diet; Disea | 2015 |
3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Cell Transformation, Neopl | 2009 |
Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line | 2010 |
3,3'-Diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antigens, Polyomavirus Transforming; Apoptosis; Ap | 2011 |
Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3).
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Growth Processes; Cell Line | 2012 |
3,3'-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppression and Treg induction.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Cell Differentiation; Cells, Cultured; Colitis, Ulcer | 2013 |