3,3'-diindolylmethane has been researched along with Colorectal Neoplasms in 6 studies
3,3'-diindolylmethane: anti-inflammatory from edible cruciferous vegetables; a cytochrome P-450 antagonist
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although 3,3'-diindolylmethane (DIM) has been suggested to reduce the risk of colorectal cancer, the underlying biological mechanism is not clearly understood." | 7.81 | FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethane inhibits migration and invasion of human colorectal cancer cells. ( Jin, H; Kim, SM; Li, XJ; Park, MH, 2015) |
| "Although 3,3'-diindolylmethane (DIM) has been suggested to reduce the risk of colorectal cancer, the underlying biological mechanism is not clearly understood." | 3.81 | FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethane inhibits migration and invasion of human colorectal cancer cells. ( Jin, H; Kim, SM; Li, XJ; Park, MH, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, X | 1 |
| Liu, J | 1 |
| Cho, KB | 1 |
| Kedika, S | 1 |
| Guo, B | 1 |
| Zhang, X | 2 |
| Sukamporn, P | 1 |
| Zhang, S | 1 |
| Min, KW | 2 |
| Baek, SJ | 2 |
| Clark, R | 1 |
| Lee, J | 1 |
| Lee, SH | 2 |
| Jin, H | 1 |
| Li, XJ | 1 |
| Park, MH | 1 |
| Kim, SM | 1 |
| Bahrami, A | 1 |
| Amerizadeh, F | 1 |
| ShahidSales, S | 1 |
| Khazaei, M | 1 |
| Ghayour-Mobarhan, M | 1 |
| Sadeghnia, HR | 1 |
| Maftouh, M | 1 |
| Hassanian, SM | 1 |
| Avan, A | 1 |
1 review available for 3,3'-diindolylmethane and Colorectal Neoplasms
| Article | Year |
|---|---|
Therapeutic Potential of Targeting Wnt/β-Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress.
Topics: Animals; Antineoplastic Agents; beta Catenin; Bridged Bicyclo Compounds, Heterocyclic; Cell Prolifer | 2017 |
5 other studies available for 3,3'-diindolylmethane and Colorectal Neoplasms
| Article | Year |
|---|---|
Chemopreventive Agent 3,3'-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells.
Topics: Apoptosis; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colorectal Neop | 2020 |
3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells.
Topics: Animals; Anticarcinogenic Agents; Cell Line, Tumor; Colorectal Neoplasms; Cyclin D1; Down-Regulation | 2017 |
Synergistic anticancer activity of capsaicin and 3,3'-diindolylmethane in human colorectal cancer.
Topics: Antineoplastic Agents; Apoptosis; Capsaicin; Cell Line, Tumor; Cell Proliferation; Colorectal Neopla | 2015 |
FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethane inhibits migration and invasion of human colorectal cancer cells.
Topics: Cadherins; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Forkhead Box Protein M1; Forkhea | 2015 |
3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells.
Topics: Activating Transcription Factor 3; Activating Transcription Factor 4; Cell Line, Tumor; Colorectal N | 2013 |