3,3'-diindolylmethane has been researched along with Colonic Neoplasms in 15 studies
3,3'-diindolylmethane: anti-inflammatory from edible cruciferous vegetables; a cytochrome P-450 antagonist
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if DIM has an antiinflammatory effect in vivo, we examined the therapeutic effects of DIM in dextran sodium sulfate (DSS)-induced experimental colitis and colitis-associated colon carcinogenesis induced by azoxymethane (AOM)/DSS in BALB/c mice." | 3.75 | 3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. ( Kang, YH; Kim, DH; Kim, JK; Kim, YH; Kwon, HS; Park, JH; Shin, EK; Shin, HK, 2009) |
| "Using clinical data from colon cancer patients, activation of β-catenin was found to be significantly associated with patient prognosis by Kaplan-Meir plot analysis." | 1.42 | Genome-wide transcriptome analysis reveals inactivation of Wnt/β-catenin by 3,3'-diindolylmethane inhibiting proliferation of colon cancer cells. ( Kim, SM; Leem, SH; Li, XJ; Park, BH; Park, MH, 2015) |
| "Treatment with sulforaphane (15 microM), PEITC (10 microM), indole-3-carbinol (10 microM) and 3,3'-diindolylmethane (10 microM) induced PARP cleavage after 24 and 48 h in both 40-16 and the 379." | 1.33 | Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. ( Barillari, J; Bartsch, H; Gerhäuser, C; Iori, R; Lichtenberg, M; Pappa, G, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tian, X | 1 |
| Liu, K | 1 |
| Zu, X | 1 |
| Ma, F | 1 |
| Li, Z | 1 |
| Lee, M | 1 |
| Chen, H | 1 |
| Li, Y | 2 |
| Zhao, Y | 1 |
| Liu, F | 1 |
| Oi, N | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
| Kim, DJ | 1 |
| Kandekar, S | 1 |
| Preet, R | 1 |
| Kashyap, M | 1 |
| Renu Prasad, MU | 1 |
| Mohapatra, P | 1 |
| Das, D | 1 |
| Satapathy, SR | 1 |
| Siddharth, S | 1 |
| Jain, V | 1 |
| Choudhuri, M | 1 |
| Kundu, CN | 1 |
| Guchhait, SK | 1 |
| Bharatam, PV | 1 |
| Li, XJ | 2 |
| Leem, SH | 2 |
| Park, MH | 2 |
| Kim, SM | 2 |
| Park, BH | 1 |
| Femia, AP | 1 |
| Soares, PV | 1 |
| Luceri, C | 1 |
| Lodovici, M | 1 |
| Giannini, A | 1 |
| Caderni, G | 1 |
| Kim, YH | 1 |
| Kwon, HS | 1 |
| Kim, DH | 1 |
| Shin, EK | 1 |
| Kang, YH | 1 |
| Park, JH | 3 |
| Shin, HK | 2 |
| Kim, JK | 1 |
| Bhatnagar, N | 1 |
| Li, X | 2 |
| Chen, Y | 1 |
| Zhou, X | 1 |
| Garrett, SH | 1 |
| Guo, B | 2 |
| Choi, HJ | 1 |
| Lim, DY | 1 |
| Lerner, A | 1 |
| Grafi-Cohen, M | 1 |
| Napso, T | 1 |
| Azzam, N | 1 |
| Fares, F | 1 |
| Pappa, G | 2 |
| Lichtenberg, M | 1 |
| Iori, R | 1 |
| Barillari, J | 1 |
| Bartsch, H | 2 |
| Gerhäuser, C | 2 |
| Kim, EJ | 1 |
| Park, SY | 1 |
| Kwon, DY | 1 |
| Surh, YJ | 1 |
| Strathmann, J | 1 |
| Löwinger, M | 1 |
| Lei, P | 1 |
| Abdelrahim, M | 1 |
| Cho, SD | 1 |
| Liu, S | 1 |
| Chintharlapalli, S | 1 |
| Safe, S | 1 |
| Gamet-Payrastre, L | 1 |
| Lumeau, S | 1 |
| Gasc, N | 1 |
| Cassar, G | 1 |
| Rollin, P | 1 |
| Tulliez, J | 1 |
15 other studies available for 3,3'-diindolylmethane and Colonic Neoplasms
| Article | Year |
|---|---|
3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.
Topics: Animals; Anticarcinogenic Agents; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase | 2019 |
Structural elaboration of a natural product: identification of 3,3'-diindolylmethane aminophosphonate and urea derivatives as potent anticancer agents.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; E | 2013 |
Regulation of YAP through an Akt-dependent process by 3, 3'-diindolylmethane in human colon cancer cells.
Topics: Anticarcinogenic Agents; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Chrom | 2013 |
Genome-wide transcriptome analysis reveals inactivation of Wnt/β-catenin by 3,3'-diindolylmethane inhibiting proliferation of colon cancer cells.
Topics: Anticarcinogenic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Gene Expression Re | 2015 |
Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Chemoprevention; Colonic Neoplasms; Curcumin; Diet; Disea | 2015 |
3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Cell Transformation, Neopl | 2009 |
3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin.
Topics: Adenocarcinoma; Adenomatous Polyposis Coli; Animals; Anticarcinogenic Agents; Apoptosis; Butyrates; | 2009 |
Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells.
Topics: Adenocarcinoma; Anticarcinogenic Agents; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cell Line, | 2009 |
Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p2 | 2010 |
The indolic diet-derivative, 3,3'-diindolylmethane, induced apoptosis in human colon cancer cells through upregulation of NDRG1.
Topics: Anticarcinogenic Agents; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cell Differentiation; Ce | 2012 |
Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Brassicaceae; Caspase 7; Caspase 9; Caspases; Cell Lin | 2006 |
Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Caspase 8; Cell Line; Cell Line, Tumor; Colonic Neoplas | 2007 |
Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro.
Topics: Anticarcinogenic Agents; Apoptosis; Brassica; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasm | 2007 |
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Collagen Type XI; Colonic Neopl | 2008 |
Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro.
Topics: Antineoplastic Agents; Caco-2 Cells; Cell Cycle; Cell Division; Colonic Neoplasms; Dose-Response Rel | 1998 |