3,3'-diindolylmethane has been researched along with Cardiomegaly in 2 studies
3,3'-diindolylmethane: anti-inflammatory from edible cruciferous vegetables; a cytochrome P-450 antagonist
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In both experiments, DIM reduced to cardiac hypertrophy and fibrosis induced by aortic banding through the activation of 5'-adenosine monophosphate-activated protein kinase-α2 (AMPKα2) and inhibition of mammalian target of the rapamycin (mTOR) signaling pathway." | 5.39 | 3,3'-Diindolylmethane protects against cardiac hypertrophy via 5'-adenosine monophosphate-activated protein kinase-α2. ( Bian, ZY; Dai, J; Deng, W; Guo, HP; Li, HL; Tang, QZ; Wu, QQ; Yuan, Y; Zhang, JY; Zhang, R; Zhang, Y; Zhou, H; Zong, J, 2013) |
| " In the present study, an in vitro model was established, using 1 µM angiotensin II (Ang II) in cultured rat cardiac H9c2 cells, to observe the effects of DIM on cardiac hypertrophy." | 3.81 | 3,3'-Diindolylmethane attenuates cardiac H9c2 cell hypertrophy through 5'-adenosine monophosphate-activated protein kinase-α. ( Bian, ZY; Dai, J; Deng, W; Fang, Y; Li, FF; Tang, QZ; Wu, QQ; Xu, M; Yuan, Y; Zhang, JY; Zhou, H; Zong, J, 2015) |
| "In both experiments, DIM reduced to cardiac hypertrophy and fibrosis induced by aortic banding through the activation of 5'-adenosine monophosphate-activated protein kinase-α2 (AMPKα2) and inhibition of mammalian target of the rapamycin (mTOR) signaling pathway." | 1.39 | 3,3'-Diindolylmethane protects against cardiac hypertrophy via 5'-adenosine monophosphate-activated protein kinase-α2. ( Bian, ZY; Dai, J; Deng, W; Guo, HP; Li, HL; Tang, QZ; Wu, QQ; Yuan, Y; Zhang, JY; Zhang, R; Zhang, Y; Zhou, H; Zong, J, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zong, J | 2 |
| Wu, QQ | 2 |
| Zhou, H | 2 |
| Zhang, JY | 2 |
| Yuan, Y | 2 |
| Bian, ZY | 2 |
| Deng, W | 2 |
| Dai, J | 2 |
| Li, FF | 1 |
| Xu, M | 1 |
| Fang, Y | 1 |
| Tang, QZ | 2 |
| Zhang, R | 1 |
| Zhang, Y | 1 |
| Guo, HP | 1 |
| Li, HL | 1 |
2 other studies available for 3,3'-diindolylmethane and Cardiomegaly
| Article | Year |
|---|---|
3,3'-Diindolylmethane attenuates cardiac H9c2 cell hypertrophy through 5'-adenosine monophosphate-activated protein kinase-α.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiomegaly; Car | 2015 |
3,3'-Diindolylmethane protects against cardiac hypertrophy via 5'-adenosine monophosphate-activated protein kinase-α2.
Topics: AMP-Activated Protein Kinases; Animals; Cardiomegaly; Cardiotonic Agents; Fibrosis; Indoles; Male; M | 2013 |