3,3'-diindolylmethane has been researched along with Cancer of Cervix in 9 studies
3,3'-diindolylmethane: anti-inflammatory from edible cruciferous vegetables; a cytochrome P-450 antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| "In C33A cervical cancer cells, DIM was more potent than I3C [dose at which the number of viable cells was 50% of that in untreated cultures (LD(50)) = 50-60 micromol/L for DIM and 200 micromol/L for I3C in a mitochondrial function assay] and faster acting." | 1.31 | Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. ( Auborn, KJ; Carter, TH; Chen, DZ; Qi, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Del Priore, G | 1 |
| Gudipudi, DK | 1 |
| Montemarano, N | 1 |
| Restivo, AM | 1 |
| Malanowska-Stega, J | 1 |
| Arslan, AA | 1 |
| Sepkovic, DW | 1 |
| Stein, J | 1 |
| Carlisle, AD | 1 |
| Ksieski, HB | 1 |
| Auborn, K | 1 |
| Raucci, L | 1 |
| Nyirenda, T | 1 |
| Bradlow, HL | 1 |
| Castañon, A | 2 |
| Tristram, A | 2 |
| Mesher, D | 1 |
| Powell, N | 2 |
| Beer, H | 1 |
| Ashman, S | 1 |
| Rieck, G | 1 |
| Fielder, H | 1 |
| Fiander, A | 2 |
| Sasieni, P | 2 |
| Zhu, J | 1 |
| Li, Y | 1 |
| Guan, C | 1 |
| Chen, Z | 1 |
| Lorincz, AT | 1 |
| Brentnall, AR | 1 |
| Vasiljević, N | 1 |
| Scibior-Bentkowska, D | 1 |
| Cuzick, J | 1 |
| Carter, TH | 3 |
| Liu, K | 1 |
| Ralph, W | 1 |
| Chen, D | 1 |
| Qi, M | 2 |
| Fan, S | 1 |
| Yuan, F | 1 |
| Rosen, EM | 1 |
| Auborn, KJ | 4 |
| Savino, JA | 1 |
| Evans, JF | 1 |
| Rabinowitz, D | 1 |
| Chen, DZ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diindolylmethane (DIM) Dietary Supplementation: A Nonsurgical Treatment for Cervical Intraepithelial Neoplasia (CIN)[NCT00212381] | Phase 3 | 62 participants (Anticipated) | Interventional | 2000-09-30 | Completed | ||
| A Single-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of 3,3'-Diindolylmethane (BR-DIM) in Patients With Systemic Lupus Erythematosus (SLE)[NCT02483624] | Phase 1 | 6 participants (Actual) | Interventional | 2016-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for 3,3'-diindolylmethane and Cancer of Cervix
| Article | Year |
|---|---|
Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia.
Topics: Administration, Oral; Adult; Double-Blind Method; Female; Humans; Indoles; Pilot Projects; Placebos; | 2010 |
Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial.
Topics: Adult; Alphapapillomavirus; Anticarcinogenic Agents; Apoptosis; Double-Blind Method; Female; Humans; | 2012 |
HPV16 L1 and L2 DNA methylation predicts high-grade cervical intraepithelial neoplasia in women with mildly abnormal cervical cytology.
Topics: Capsid Proteins; Cervix Uteri; Colposcopy; DNA Methylation; DNA, Viral; Female; Human papillomavirus | 2013 |
6 other studies available for 3,3'-diindolylmethane and Cancer of Cervix
| Article | Year |
|---|---|
Results from a dose-response study using 3,3'-diindolylmethane in the K14-HPV16 transgenic mouse model: cervical histology.
Topics: Animals; Anticarcinogenic Agents; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; | 2011 |
Anti-proliferative and pro-apoptotic effects of 3,3'-diindolylmethane in human cervical cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell P | 2012 |
Diindolylmethane alters gene expression in human keratinocytes in vitro.
Topics: Blotting, Western; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Proteins; Cells, Cult | 2002 |
Multiple, disparate roles for calcium signaling in apoptosis of human prostate and cervical cancer cells exposed to diindolylmethane.
Topics: Apoptosis; Benzylamines; Calcium; Calcium Signaling; Chelating Agents; Cyclosporine; Cytosol; Egtazi | 2006 |
Can indole-3-carbinol-induced changes in cervical intraepithelial neoplasia be extrapolated to other food components?
Topics: Animals; Brassica; Female; Humans; Indoles; Randomized Controlled Trials as Topic; Uterine Cervical | 2006 |
Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; DNA Fragmentati | 2001 |