3,3'-diindolylmethane has been researched along with Angiogenesis, Pathologic in 8 studies
3,3'-diindolylmethane: anti-inflammatory from edible cruciferous vegetables; a cytochrome P-450 antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| "NGD16 suppressed the viability of prostate cancer (PC-3), pancreatic adenocarcinoma (MiaPaca-2), colorectal cancer (COLO-205) and human umbilical vein endothelial cells (HUVECs) effectively with IC50 values 0." | 1.42 | A therapeutically relevant, 3,3'-diindolylmethane derivative NGD16 attenuates angiogenesis by targeting glucose regulated protein, 78kDa (GRP78). ( Amin, H; Goswami, A; Gupta, AP; Kushwaha, M; Mukherjee, D; Nayak, D; Rah, B; Sharma, D; Ur Rasool, R, 2015) |
| "In this study, three human thyroid cancer cells (B-CPAP, CGTH-W-1, ML-1) were treated with estrogen alone or estrogen and anti-estrogens (fulvestrant and 3,3'-diindolylmethane, a natural dietary compound) for 24 hours." | 1.38 | Molecular target based combinational therapeutic approaches in thyroid cancer. ( Geliebter, J; George, AL; Kamat, A; Rajoria, S; Schantz, SP; Suriano, R; Tiwari, RK, 2012) |
| " We found that BioResponse DIM (B-DIM), a formulated DIM with higher bioavailability, inhibited angiogenesis and invasion by reducing the bioavailability of vascular endothelial growth factor (VEGF) via repressing extracellular matrix-degrading proteases, such as matrix metalloproteinase (MMP)-9 and urokinase-type plasminogen activator (uPA), in human prostate cancer cells and reduced vascularity (angiogenesis) in vivo using Matrigel plug assay." | 1.34 | Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. ( Banerjee, S; Kong, D; Li, Y; Sarkar, FH; Wang, Z, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Penta, D | 1 |
| Natesh, J | 1 |
| Mondal, P | 1 |
| Meeran, SM | 1 |
| Ampofo, E | 1 |
| Schmitt, BM | 1 |
| Menger, MD | 1 |
| Laschke, MW | 1 |
| Nayak, D | 1 |
| Amin, H | 1 |
| Rah, B | 1 |
| Ur Rasool, R | 1 |
| Sharma, D | 1 |
| Gupta, AP | 1 |
| Kushwaha, M | 1 |
| Mukherjee, D | 1 |
| Goswami, A | 1 |
| Rajoria, S | 1 |
| Suriano, R | 1 |
| George, AL | 1 |
| Kamat, A | 1 |
| Schantz, SP | 1 |
| Geliebter, J | 1 |
| Tiwari, RK | 1 |
| Chang, X | 2 |
| Tou, JC | 1 |
| Hong, C | 1 |
| Kim, HA | 1 |
| Riby, JE | 1 |
| Firestone, GL | 2 |
| Bjeldanes, LF | 2 |
| Kong, D | 2 |
| Li, Y | 2 |
| Wang, Z | 2 |
| Banerjee, S | 2 |
| Sarkar, FH | 2 |
| Huang, W | 1 |
| Kim, HR | 1 |
1 review available for 3,3'-diindolylmethane and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Targeting the Microcirculation by Indole-3-carbinol and Its Main Derivate 3,3,'-diindolylmethane: Effects on Angiogenesis, Thrombosis and Inflammation.
Topics: Animals; Humans; Indoles; Inflammation; Microcirculation; Neovascularization, Pathologic; Thrombosis | 2018 |
7 other studies available for 3,3'-diindolylmethane and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Dietary Diindolylmethane Enhances the Therapeutic Effect of Centchroman in Breast Cancer by Inhibiting Neoangiogenesis.
Topics: Cell Line, Tumor; Cell Proliferation; Centchroman; Humans; Neovascularization, Pathologic; Triple Ne | 2023 |
A therapeutically relevant, 3,3'-diindolylmethane derivative NGD16 attenuates angiogenesis by targeting glucose regulated protein, 78kDa (GRP78).
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug | 2015 |
Molecular target based combinational therapeutic approaches in thyroid cancer.
Topics: Antibodies, Neutralizing; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Mov | 2012 |
3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice.
Topics: Angiogenesis Inhibitors; Animals; Anticarcinogenic Agents; Breast Neoplasms; Cell Movement; Cell Pro | 2005 |
Inhibition of growth factor-induced Ras signaling in vascular endothelial cells and angiogenesis by 3,3'-diindolylmethane.
Topics: Anticarcinogenic Agents; Cell Culture Techniques; Cell Proliferation; DNA; Endothelial Cells; Humans | 2006 |
Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer.
Topics: Anticarcinogenic Agents; Cell Line, Tumor; DNA, Neoplasm; Down-Regulation; Endothelial Cells; Humans | 2007 |
Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells.
Topics: Cell Growth Processes; Cell Line, Tumor; Enzyme Activation; Humans; Indoles; Lymphokines; Male; Neop | 2008 |