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3,3',5-triiodothyroacetic acid and Hypothyroidism

3,3',5-triiodothyroacetic acid has been researched along with Hypothyroidism in 15 studies

tiratricol : A monocarboxylic acid that is (4-hydroxy-3,5-diiodophenyl)acetic acid in which the phenolic hydroxy group has been replaced by a 4-hydroxy-3-iodophenoxy group. It is a thyroid hormone analogue that has been used in the treatment of thyroid hormone resistance syndrome.

Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.

Research Excerpts

ExcerptRelevanceReference
"Euthyroid goiter is usually treated with TSH-inhibitory doses of levo-T(4) (L-T(4))."6.71Comparative efficacy and side effects of the treatment of euthyroid goiter with levo-thyroxine or triiodothyroacetic acid. ( Blanco, A; Brenta, G; Damilano, S; Facco, E; Fretes, O; Gonzalez, E; Gurfinkel, M; Pacenza, N; Pisarev, MA; Schnitman, M, 2003)
"The diagnosis of fetal hypothyroidism is based at present on measurements of TSH and free thyroxine (FT4) in fetal blood samples obtained by cordocentesis."3.70Maternal compound W serial measurements for the management of fetal hypothyroidsm. ( Beck-Peccoz, P; Cortelazzi, D; Fisher, DA; Morpurgo, PS; Wu, SY; Zamperini, P, 1999)
"Following the diagnosis of fetal goitre at 22 and 24 weeks' gestation in two hyperthyroid pregnant women who underwent treatment with 400-500 mg of propylthiouracil in the first weeks of pregnancy, a total of seven fetal blood samplings were performed to evaluate thyroid function before and after the initiation of two different treatment regimens."3.69Prenatal treatment of fetal hypothyroidism: is there more than one option? ( Acaia, B; Beck-Peccoz, P; Cortelazzi, D; Nicolini, U; Venegoni, E, 1996)
"In order to compare the effect of 3,5,3'-triiodothyroacetic acid (TRIAC) with those of triiodothyronine (T3) and thyroxine (T4), severely hypothyroid rats (n=56) were infused over 13 days with 1, 2 or 4 nmol/100 g body weight (BW) per day of T3 or 2, 4 or 8 nmol/100 g BW per day of T4 or TRIAC."3.69Organ-specific effects of 3,5,3'-triiodothyroacetic acid in rats. ( Burger, AG; Juge-Aubry, CE; Liang, H; O'Connell, M, 1997)
"Euthyroid goiter is usually treated with TSH-inhibitory doses of levo-T(4) (L-T(4))."2.71Comparative efficacy and side effects of the treatment of euthyroid goiter with levo-thyroxine or triiodothyroacetic acid. ( Blanco, A; Brenta, G; Damilano, S; Facco, E; Fretes, O; Gonzalez, E; Gurfinkel, M; Pacenza, N; Pisarev, MA; Schnitman, M, 2003)
"After successful treatment of hyperthyroidism, SHBG levels normalized in patients with nIST, but they did not change in patients with nnIST."1.28Sex hormone-binding globulin measurement in patients with inappropriate secretion of thyrotropin (IST): evidence against selective pituitary thyroid hormone resistance in nonneoplastic IST. ( Beck-Peccoz, P; Brabant, G; Faglia, G; Forloni, F; Marcocci, C; Mariotti, S; Medri, G; Pinchera, A; Roncoroni, R, 1990)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19904 (26.67)18.7374
1990's8 (53.33)18.2507
2000's3 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Scally, MC1
Hodge, A1
Brenta, G1
Schnitman, M1
Fretes, O1
Facco, E1
Gurfinkel, M1
Damilano, S1
Pacenza, N1
Blanco, A1
Gonzalez, E1
Pisarev, MA1
Bentin, J1
Désir, D1
Mockel, J1
Medeiros-Neto, G1
Kallas, WG1
Knobel, M1
Cavaliere, H1
Mattar, E1
Heim, J1
Gavin, LA1
Livermore, BM1
Cavalieri, RR1
Hammond, ME1
Castle, JN1
Juge-Aubry, CE2
Morin, O1
Pernin, AT1
Liang, H2
Philippe, J1
Burger, AG2
Carlin, K1
Carlin, S1
Nicolini, U1
Venegoni, E1
Acaia, B1
Cortelazzi, D3
Beck-Peccoz, P4
Bertola, G1
Bocchia, M1
Milani, D1
Sherman, SI1
Ringel, MD1
Smith, MJ1
Kopelen, HA1
Zoghbi, WA1
Ladenson, PW1
O'Connell, M1
Morpurgo, PS1
Zamperini, P1
Fisher, DA1
Wu, SY1
Ciulla, MM1
Paliotti, R1
Tortora, G1
Barelli, MV1
Buonamici, V1
Magrini, F1
Roncoroni, R1
Mariotti, S1
Medri, G1
Marcocci, C1
Brabant, G1
Forloni, F1
Pinchera, A1
Faglia, G1

Trials

2 trials available for 3,3',5-triiodothyroacetic acid and Hypothyroidism

ArticleYear
Comparative efficacy and side effects of the treatment of euthyroid goiter with levo-thyroxine or triiodothyroacetic acid.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:11

    Topics: Adult; Blood Pressure; Bone and Bones; Goiter; Heart Rate; Humans; Hypothyroidism; Liver; Male; Midd

2003
Augmented hepatic and skeletal thyromimetic effects of tiratricol in comparison with levothyroxine.
    The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:7

    Topics: Adult; Aged; Apolipoproteins; Bone and Bones; Cardiovascular System; Cholesterol; Double-Blind Metho

1997

Other Studies

13 other studies available for 3,3',5-triiodothyroacetic acid and Hypothyroidism

ArticleYear
A report of hypothyroidism induced by an over-the-counter fat loss supplement (Tiratricol).
    International journal of sport nutrition and exercise metabolism, 2003, Volume: 13, Issue:1

    Topics: Adult; Anti-Obesity Agents; Diet, Fat-Restricted; Dietary Supplements; Fatigue; Female; Humans; Hypo

2003
Triac (3,5,3'-triiodo-thyroacetic acid) induced "pseudohypothyroidism".
    Acta clinica Belgica, 1984, Volume: 39, Issue:5

    Topics: Adult; Female; Humans; Hypothyroidism; Obesity; Thyroid Hormones; Thyrotropin; Triiodothyronine

1984
Triac (3,5,3'-triiodothyroacetic acid) partially inhibits the thyrotropin response to synthetic thyrotropin-releasing hormone in normal and thyroidectomized hypothyroid patients.
    The Journal of clinical endocrinology and metabolism, 1980, Volume: 50, Issue:2

    Topics: Adult; Female; Humans; Hypothyroidism; Male; Prolactin; Reference Values; Thyroidectomy; Thyrotropin

1980
[Hypothyroidism of central origin corrected by the cessation of Triac therapy].
    Annales de medecine interne, 1982, Volume: 133, Issue:8

    Topics: Female; Humans; Hypothalamo-Hypophyseal System; Hypothyroidism; Middle Aged; Obesity; Thyroid Hormon

1982
Serum concentration, metabolic clearance, and production rates of 3,5,3'-triiodothyroacetic acid in normal and athyreotic man.
    The Journal of clinical endocrinology and metabolism, 1980, Volume: 51, Issue:3

    Topics: Humans; Hypothyroidism; Kinetics; Male; Metabolic Clearance Rate; Radioimmunoassay; Thyroxine; Triio

1980
Long-lasting effects of Triac and thyroxine on the control of thyrotropin and hepatic deiodinase type I.
    European journal of endocrinology, 1995, Volume: 132, Issue:6

    Topics: Animals; Hypothyroidism; Iodide Peroxidase; Kidney; Liver; Male; Organ Specificity; Pituitary Gland;

1995
Possible etiology for euthyroid sick syndrome.
    Medical hypotheses, 1993, Volume: 40, Issue:1

    Topics: Animals; Euthyroid Sick Syndromes; Feedback; Gluconeogenesis; Humans; Hypothalamo-Hypophyseal System

1993
Prenatal treatment of fetal hypothyroidism: is there more than one option?
    Prenatal diagnosis, 1996, Volume: 16, Issue:5

    Topics: Adult; Amniotic Fluid; Female; Fetal Blood; Gestational Age; Humans; Hyperthyroidism; Hypothyroidism

1996
[Inhibitory effects of triiodothyroacetic acid on TSH secretion. A case of apparent central hypothyroidism].
    Minerva endocrinologica, 1996, Volume: 21, Issue:3

    Topics: Diagnosis, Differential; Female; Humans; Hypothyroidism; Middle Aged; Thyrotropin; Triiodothyronine

1996
Organ-specific effects of 3,5,3'-triiodothyroacetic acid in rats.
    European journal of endocrinology, 1997, Volume: 137, Issue:5

    Topics: Animals; Body Weight; Growth Hormone; Hypothyroidism; Iodide Peroxidase; Myocardium; Organ Size; Rat

1997
Maternal compound W serial measurements for the management of fetal hypothyroidsm.
    European journal of endocrinology, 1999, Volume: 141, Issue:6

    Topics: Biomarkers; Cordocentesis; Diiodothyronines; Female; Fetal Blood; Fetal Diseases; Gestational Age; H

1999
Effects of thyroid hormones on cardiac structure: a tissue characterization study in patients with thyroid disorders before and after treatment.
    Thyroid : official journal of the American Thyroid Association, 2001, Volume: 11, Issue:7

    Topics: Adult; Antithyroid Agents; Collagen; Echocardiography; Electrocardiography; Female; Humans; Hyperthy

2001
Sex hormone-binding globulin measurement in patients with inappropriate secretion of thyrotropin (IST): evidence against selective pituitary thyroid hormone resistance in nonneoplastic IST.
    The Journal of clinical endocrinology and metabolism, 1990, Volume: 71, Issue:1

    Topics: Adenoma; Adolescent; Adult; Child; Diagnosis, Differential; Drug Resistance; Female; Humans; Hyperth

1990