3--hydroxy-5--(4-isobutylpiperazinyl)benzoxazinorifamycin has been researched along with Helicobacter-Infections* in 3 studies
3 other study(ies) available for 3--hydroxy-5--(4-isobutylpiperazinyl)benzoxazinorifamycin and Helicobacter-Infections
| Article | Year |
|---|---|
Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
TNP-2198, a stable conjugate of a rifamycin pharmacophore and a nitroimidazole pharmacophore, has been designed, synthesized, and evaluated as a novel dual-targeted antibacterial agent for the treatment of microaerophilic and anaerobic bacterial infections. TNP-2198 exhibits greater activity than a 1:1 molar mixture of the parent drugs and exhibits activity against strains resistant to both rifamycins and nitroimidazoles. A crystal structure of TNP-2198 bound to a Topics: Anaerobiosis; DNA-Directed RNA Polymerases; Helicobacter Infections; Helicobacter pylori; Humans; Nitroimidazoles; Rifamycins | 2022 |
Rifalazil and derivative compounds show potent efficacy in a mouse model of H. pylori colonization.
The rifamycin rifalazil (RFZ), and derivatives (NCEs) were efficacious in a mouse model of Helicobacter pylori colonization. Select NCEs were more active in vitro and showed greater efficacy than RFZ. A systemic component contributes to efficacy. Topics: Animals; Antibiotics, Antitubercular; Disease Models, Animal; Helicobacter Infections; Helicobacter pylori; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Rifamycins | 2008 |
Detection of rifabutin resistance and association of rpoB mutations with resistance to four rifamycin derivatives in Helicobacter pylori.
Topics: DNA-Directed RNA Polymerases; Drug Resistance, Multiple; Helicobacter Infections; Helicobacter pylori; Humans; Microbial Sensitivity Tests; Mutation; Rifabutin; Rifamycins; Sensitivity and Specificity | 2002 |