3--fluoro-2--3--dideoxyguanosine and Hepatitis--Viral--Animal

3--fluoro-2--3--dideoxyguanosine has been researched along with Hepatitis--Viral--Animal* in 1 studies

Other Studies

1 other study(ies) available for 3--fluoro-2--3--dideoxyguanosine and Hepatitis--Viral--Animal

Article	Year
Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:3 The antiviral activity of 2',3'-dideoxy-3'-fluoroguanosine (FdG) or its triphosphate was evaluated in the duck hepatitis B virus (DHBV) system in vitro and in vivo. In primary DHBV-infected hepatocytes FdG results in a dose-dependent inhibition of viral replication with a nearly complete inhibition at a concentration of 1 microM. Also in vivo, FdG treatment of DHBV-infected ducklings reduces DHBV DNA replication by more than 90%. These data demonstrate that FdG is a strong inhibitor of DHBV replication in vitro and in vivo. Topics: Animals; Antiviral Agents; Blotting, Southern; Cell Survival; Cells, Cultured; Dideoxynucleosides; DNA, Viral; Ducks; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; In Situ Hybridization; Liver; Virus Replication	1996

Article

Year

Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo.

Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:3

The antiviral activity of 2',3'-dideoxy-3'-fluoroguanosine (FdG) or its triphosphate was evaluated in the duck hepatitis B virus (DHBV) system in vitro and in vivo. In primary DHBV-infected hepatocytes FdG results in a dose-dependent inhibition of viral replication with a nearly complete inhibition at a concentration of 1 microM. Also in vivo, FdG treatment of DHBV-infected ducklings reduces DHBV DNA replication by more than 90%. These data demonstrate that FdG is a strong inhibitor of DHBV replication in vitro and in vivo.

Topics: Animals; Antiviral Agents; Blotting, Southern; Cell Survival; Cells, Cultured; Dideoxynucleosides; DNA, Viral; Ducks; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; In Situ Hybridization; Liver; Virus Replication

1996