3-(n-n-dimethylsulfonamido)-4-methyl-nitrobenzene has been researched along with Inflammation* in 1 studies
1 other study(ies) available for 3-(n-n-dimethylsulfonamido)-4-methyl-nitrobenzene and Inflammation
| Article | Year |
|---|---|
New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases.
Herein, we describe the rapid synthesis of a focused library of trisubstituted imidazo[4,5-b]pyridines and imidazo[4,5-c]pyridines from 2,4-dichloro-3-nitropyridine using the combination of solution-phase/solid-phase chemistry as new potential anti-inflammatory agents in the treatment of autoimmune diseases. Structure-activity relationship studies, followed by the structure optimization, provided hit compounds (17 and 28) which inhibited phosphodiesterase 4 (PDE4) with IC Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Female; Humans; Imidazoles; Inflammation; Male; Mice, Inbred BALB C; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pyridines; Rats, Wistar | 2021 |