Compounds > 3-(n-n-dimethylsulfonamido)-4-methyl-nitrobenzene

3-(n-n-dimethylsulfonamido)-4-methyl-nitrobenzene and Dermatitis--Atopic

3-(n-n-dimethylsulfonamido)-4-methyl-nitrobenzene has been researched along with Dermatitis--Atopic* in 1 studies

Other Studies

1 other study(ies) available for 3-(n-n-dimethylsulfonamido)-4-methyl-nitrobenzene and Dermatitis--Atopic

ArticleYear
Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.
    Bioorganic & medicinal chemistry letters, 2009, Apr-15, Volume: 19, Issue:8

    A series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory activity against PDE4 and cytokine release. 5-(4-Cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2728) showed potent activity both in vitro and in vivo. This compound is now in clinical development for the topical treatment of psoriasis and being pursued for the topical treatment of atopic dermatitis.

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dermatitis, Atopic; Dermatologic Agents; Edema; Humans; Mice; Psoriasis; Structure-Activity Relationship; U937 Cells

2009