3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Stroke in 3 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kong, L | 1 |
| Ma, Y | 1 |
| Wang, Z | 1 |
| Liu, N | 1 |
| Ma, G | 1 |
| Liu, C | 1 |
| Shi, R | 1 |
| Du, G | 1 |
| Lee, WT | 1 |
| Tai, SH | 1 |
| Lin, YW | 1 |
| Wu, TS | 1 |
| Lee, EJ | 1 |
| Yan, J | 1 |
| Zhou, B | 1 |
| Taheri, S | 1 |
| Shi, H | 1 |
3 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Stroke
| Article | Year |
|---|---|
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
Topics: Animals; Brain Ischemia; Cerebral Hemorrhage; Endothelial Cells; HMGB1 Protein; Hypoxia-Inducible Fa | 2021 |
YC‑1 reduces inflammatory responses by inhibiting nuclear factor‑κB translocation in mice subjected to transient focal cerebral ischemia.
Topics: Animals; Brain Edema; Brain Ischemia; Indazoles; Interleukin-1beta; Interleukin-6; Matrix Metallopro | 2018 |
Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Endothelial Cells; Gene Expres | 2011 |