3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Squamous Cell Carcinoma of Head and Neck in 1 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Squamous Cell Carcinoma of Head and Neck: The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Head and neck squamous cell carcinoma (HNSCC) is an aggressive and often fatal disease." | 1.46 | Soluble guanylate cyclase stimulators increase sensitivity to cisplatin in head and neck squamous cell carcinoma cells. ( Ben-Jonathan, N; Kumar, B; Kumar, P; Takiar, V; Tuttle, TR, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tuttle, TR | 1 |
| Takiar, V | 1 |
| Kumar, B | 1 |
| Kumar, P | 1 |
| Ben-Jonathan, N | 1 |
1 other study available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Squamous Cell Carcinoma of Head and Neck
| Article | Year |
|---|---|
Soluble guanylate cyclase stimulators increase sensitivity to cisplatin in head and neck squamous cell carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; beta Catenin; Carcinoma, Squamous Cell | 2017 |