3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Pregnancy in 4 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preeclampsia is a serious complication of pregnancy with no medical treatment." | 1.42 | YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia. ( Brownfoot, FC; Cannon, P; Hannan, NJ; Hastie, R; Kaitu'u-Lino, TJ; Tong, S; Tuohey, L, 2015) |
| "We conclude that in preeclampsia, the decrease of relaxation responses and the decrease of cGMP content could be due to the reduction in stimulation of sGC and the decrease in cGMP levels." | 1.39 | Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model. ( Bagcivan, I; Karadas, B; Parlak, M; Temiz, TK; Turgut, B; Turgut, NH, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Turgut, NH | 1 |
| Temiz, TK | 1 |
| Turgut, B | 1 |
| Karadas, B | 3 |
| Parlak, M | 1 |
| Bagcivan, I | 2 |
| Brownfoot, FC | 1 |
| Tong, S | 1 |
| Hannan, NJ | 1 |
| Hastie, R | 1 |
| Cannon, P | 1 |
| Tuohey, L | 1 |
| Kaitu'u-Lino, TJ | 1 |
| Cetin, A | 2 |
| Kaya, T | 2 |
| Demirkoprulu, N | 2 |
| Duran, B | 1 |
| Cetin, M | 2 |
| Soydan, AS | 1 |
4 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Pregnancy
| Article | Year |
|---|---|
Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relation | 2013 |
YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia.
Topics: Adult; Antigens, CD; Endoglin; Female; Human Umbilical Vein Endothelial Cells; Humans; Indazoles; Pl | 2015 |
YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits the spontaneous contractions of isolated pregnant rat myometrium.
Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Enzyme Activators; Female; Glyburid | 2004 |
Comparative relaxant effects of YC-1 and DETA/NO on spontaneous contractions and the levels of cGMP of isolated pregnant rat myometrium.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indazoles; Male; | 2005 |