3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Ovarian Neoplasms in 6 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The molecular mechanisms of ovarian cancer cell invasion under hypoxia remain unclear." | 1.42 | Hypoxia promotes HO-8910PM ovarian cancer cell invasion via Snail-mediated MT1-MMP upregulation. ( Deng, LL; Lin, P; Liu, Y; Lu, C; Qin, Z; Sun, L, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, JC | 1 |
| Chou, LC | 1 |
| Lien, JC | 1 |
| Wu, JC | 1 |
| Huang, CH | 1 |
| Chung, CH | 1 |
| Lee, FY | 1 |
| Huang, LJ | 1 |
| Kuo, SC | 1 |
| Way, TD | 1 |
| Liu, T | 1 |
| Zhao, L | 1 |
| Chen, W | 1 |
| Li, Z | 1 |
| Hou, H | 1 |
| Ding, L | 1 |
| Li, X | 1 |
| Sun, L | 1 |
| Lin, P | 1 |
| Qin, Z | 1 |
| Liu, Y | 1 |
| Deng, LL | 1 |
| Lu, C | 1 |
| Lee, SJ | 1 |
| Kim, YJ | 3 |
| Lee, CS | 3 |
| Bae, J | 1 |
| Kim, W | 2 |
| Myung, SC | 2 |
| Kwak, SW | 1 |
| Lee, SA | 1 |
| Park, ES | 1 |
| Lee, MS | 1 |
| Lee, JJ | 1 |
6 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Ovarian Neoplasms
| Article | Year |
|---|---|
CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo.
Topics: Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal, Humanized; Apoptosis; Breast Neoplasms | 2013 |
Inactivation of von Hippel-Lindau increases ovarian cancer cell aggressiveness through the HIF1α/miR-210/VMP1 signaling pathway.
Topics: Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; I | 2014 |
Hypoxia promotes HO-8910PM ovarian cancer cell invasion via Snail-mediated MT1-MMP upregulation.
Topics: Animals; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chick Embryo; | 2015 |
Combined application of camptothecin and the guanylate cyclase activator YC-1: Impact on cell death and apoptosis-related proteins in ovarian carcinoma cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line, Tumor; DNA Damage; Enzyme Act | 2009 |
Guanylate cyclase activator YC-1 enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells via activation of apoptosis-related proteins.
Topics: Apoptosis; Biomarkers, Tumor; Caspase 8; Cell Line, Tumor; Enzyme Activators; Female; Guanylate Cycl | 2011 |
Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma; Carcinoma, O | 2012 |