3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Neuroblastoma in 3 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Little is known about the importance of hypoxia in pediatric tumors; therefore, we evaluated the effects of hypoxia on the response of the neuroblastoma cell lines SH-EP1 and SH-SY5Y to the clinically relevant drugs, vincristine, etoposide, and cisplatin." | 7.73 | Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells. ( Dive, C; Estlin, EJ; Hussein, D; Makin, GW, 2006) |
| " Little is known about the importance of hypoxia in pediatric tumors; therefore, we evaluated the effects of hypoxia on the response of the neuroblastoma cell lines SH-EP1 and SH-SY5Y to the clinically relevant drugs, vincristine, etoposide, and cisplatin." | 3.73 | Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells. ( Dive, C; Estlin, EJ; Hussein, D; Makin, GW, 2006) |
| "Hep3B hepatoma, NCI-H87 stomach carcinoma, Caki-1 renal carcinoma, SiHa cervical carcinoma, and SK-N-MC neuroblastoma cells were grown as xenografts in immunodeficient mice (69 mice total)." | 1.32 | YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. ( Cho, YS; Chun, YS; Kim, J; Kim, MS; Lee, JC; Park, JW; Yeo, EJ, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chio, CC | 1 |
| Lin, JW | 1 |
| Cheng, HA | 1 |
| Chiu, WT | 1 |
| Wang, YH | 1 |
| Wang, JJ | 1 |
| Hsing, CH | 1 |
| Chen, RM | 1 |
| Yeo, EJ | 1 |
| Chun, YS | 1 |
| Cho, YS | 1 |
| Kim, J | 1 |
| Lee, JC | 1 |
| Kim, MS | 1 |
| Park, JW | 1 |
| Hussein, D | 1 |
| Estlin, EJ | 1 |
| Dive, C | 1 |
| Makin, GW | 1 |
3 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Neuroblastoma
| Article | Year |
|---|---|
MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells.
Topics: 3' Untranslated Regions; Animals; Apoptosis; Binding Sites; Cell Hypoxia; Cell Line, Tumor; Cell Sur | 2013 |
YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Hepatocellular; Cell | 2003 |
Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells.
Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cisplatin; Down-Regulation; Drug Resistance, Neoplasm; Et | 2006 |