3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Neoplasm Metastasis in 6 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Parkin downregulation in breast cancer cells promotes metastasis, which can be inhibited by targeting HIF-1α with RNA interference or the small-molecule inhibitor YC-1." | 1.46 | Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. ( Chen, J; Feng, Z; Gao, J; Gatza, ML; Haffty, BG; Hu, W; Huang, S; Khella, CA; Liu, J; Tomsky, K; White, E; Wu, H; Xia, D; Xie, H; Yue, X; Zhang, C; Zhao, Y, 2017) |
| "The molecular mechanisms of ovarian cancer cell invasion under hypoxia remain unclear." | 1.42 | Hypoxia promotes HO-8910PM ovarian cancer cell invasion via Snail-mediated MT1-MMP upregulation. ( Deng, LL; Lin, P; Liu, Y; Lu, C; Qin, Z; Sun, L, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Zhang, C | 1 |
| Zhao, Y | 1 |
| Yue, X | 1 |
| Wu, H | 1 |
| Huang, S | 1 |
| Chen, J | 1 |
| Tomsky, K | 1 |
| Xie, H | 1 |
| Khella, CA | 1 |
| Gatza, ML | 1 |
| Xia, D | 1 |
| Gao, J | 1 |
| White, E | 1 |
| Haffty, BG | 1 |
| Hu, W | 1 |
| Feng, Z | 1 |
| Zhao, W | 1 |
| Li, X | 1 |
| Li, Z | 1 |
| Sun, L | 1 |
| Lin, P | 1 |
| Qin, Z | 1 |
| Liu, Y | 2 |
| Deng, LL | 1 |
| Lu, C | 1 |
| Cheng, Y | 1 |
| Li, W | 1 |
| Cheng, HC | 1 |
| Ma, J | 1 |
| Qiu, L | 1 |
| Shin, DH | 1 |
| Kim, JH | 1 |
| Jung, YJ | 1 |
| Kim, KE | 1 |
| Jeong, JM | 1 |
| Chun, YS | 1 |
| Park, JW | 1 |
| Chen, CJ | 1 |
| Hsu, MH | 1 |
| Huang, LJ | 1 |
| Yamori, T | 1 |
| Chung, JG | 1 |
| Lee, FY | 1 |
| Teng, CM | 1 |
| Kuo, SC | 1 |
6 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Neoplasm Metastasis
| Article | Year |
|---|---|
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Down-Regulation; Female; Heterografts; H | 2017 |
Combination therapy with local radiofrequency ablation and YC-1 inhibits the proliferation and metastasis of hepatocellular carcinoma through activating β-catenin signaling.
Topics: Animals; Apoptosis; beta Catenin; Catheter Ablation; Cell Line, Tumor; Cell Movement; Cell Prolifera | 2016 |
Hypoxia promotes HO-8910PM ovarian cancer cell invasion via Snail-mediated MT1-MMP upregulation.
Topics: Animals; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chick Embryo; | 2015 |
YC-1 exerts inhibitory effects on MDA-MB-468 breast cancer cells by targeting EGFR in vitro and in vivo under normoxic condition.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Prol | 2012 |
Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Drug S | 2007 |
Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; G1 Phase; Huma | 2008 |