3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Muscle Relaxation in 19 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Guanylyl cyclase converts GTP to cyclic GMP as part of the cascade that results in physiological processes such as smooth muscle relaxation, neurotransmission, inhibition of platelet aggregation and immune response." | 3.72 | A-350619: a novel activator of soluble guanylyl cyclase. ( Brioni, JD; Chang, R; Hsieh, GC; Kolasa, T; Miller, LN; Moreland, RB; Nakane, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 13 (68.42) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aydin, C | 1 |
| Bagcivan, I | 3 |
| Yildirim, S | 1 |
| Koyuncu, A | 1 |
| Topcu, O | 1 |
| Soylu, S | 1 |
| Ozer, H | 1 |
| Triguero, D | 1 |
| Sancho, M | 1 |
| García-Flores, M | 1 |
| García-Pascual, A | 1 |
| Miller, LN | 1 |
| Nakane, M | 1 |
| Hsieh, GC | 1 |
| Chang, R | 1 |
| Kolasa, T | 1 |
| Moreland, RB | 1 |
| Brioni, JD | 1 |
| Che, Y | 2 |
| Rand, MJ | 1 |
| Li, CG | 2 |
| Linder, AE | 2 |
| McCluskey, LP | 1 |
| Cole, KR | 1 |
| Lanning, KM | 1 |
| Webb, RC | 2 |
| Demirkoprulu, N | 1 |
| Cetin, M | 1 |
| Kaya, T | 2 |
| Soydan, AS | 1 |
| Karadas, B | 2 |
| Cetin, A | 1 |
| Ellis, A | 1 |
| Weber, DS | 1 |
| Whitesall, SE | 1 |
| D'Alecy, LG | 1 |
| González-Luis, G | 1 |
| Cogolludo, A | 1 |
| Moreno, L | 1 |
| Lodi, F | 1 |
| Tamargo, J | 1 |
| Pérez-Vizcaíno, F | 1 |
| Villamor, E | 1 |
| Turan, M | 1 |
| Sarac, B | 1 |
| Duman, M | 1 |
| Mülsch, A | 1 |
| Bauersachs, J | 1 |
| Schäfer, A | 1 |
| Stasch, JP | 1 |
| Kast, R | 1 |
| Busse, R | 1 |
| Wegener, JW | 2 |
| Nawrath, H | 2 |
| Galle, J | 1 |
| Zabel, U | 1 |
| Hübner, U | 1 |
| Hatzelmann, A | 1 |
| Wagner, B | 1 |
| Wanner, C | 1 |
| Schmidt, HH | 1 |
| Hwang, TL | 1 |
| Wu, CC | 1 |
| Teng, CM | 1 |
| Seitz, S | 1 |
| Rupp, J | 1 |
| Watanabe, M | 1 |
| Jost, A | 1 |
| Gerhard, R | 1 |
| Shainberg, A | 1 |
| Ochi, R | 1 |
| Wohlfart, P | 1 |
| Malinski, T | 1 |
| Ruetten, H | 1 |
| Schindler, U | 1 |
| Linz, W | 1 |
| Schoenafinger, K | 1 |
| Strobel, H | 1 |
| Wiemer, G | 1 |
| McLaughlin, BE | 2 |
| Chretien, ML | 1 |
| Choi, C | 1 |
| Brien, JF | 2 |
| Nakatsu, K | 2 |
| Marks, GS | 2 |
| O'Reilly, DA | 1 |
| Schroder, A | 1 |
| Hedlund, P | 1 |
| Andersson, KE | 1 |
19 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Muscle Relaxation
| Article | Year |
|---|---|
Effect of nitric oxide/cyclic guanosine mono-phosphate pathway on gallbladder relaxant response in bile duct-ligated guinea pigs.
Topics: Amrinone; Animals; Arginine; Bile Ducts; Cyclic GMP; Gallbladder; Guanidines; Guinea Pigs; Hydrazine | 2009 |
Presence of cyclic nucleotide-gated channels in the rat urethra and their involvement in nerve-mediated nitrergic relaxation.
Topics: Animals; Calcium Channel Blockers; Cyclic Nucleotide-Gated Cation Channels; Diltiazem; Enzyme Inhibi | 2009 |
A-350619: a novel activator of soluble guanylyl cyclase.
Topics: Acrylamides; Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activato | 2003 |
Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle.
Topics: Animals; Aorta; Azoles; Copper; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, D | 2003 |
Dynamic association of nitric oxide downstream signaling molecules with endothelial caveolin-1 in rat aorta.
Topics: Acetylcholine; Animals; beta-Cyclodextrins; Caveolae; Caveolin 1; Caveolins; Cyclic AMP-Dependent Pr | 2005 |
Comparative relaxant effects of YC-1 and DETA/NO on spontaneous contractions and the levels of cGMP of isolated pregnant rat myometrium.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indazoles; Male; | 2005 |
Enhanced responsiveness to nitric oxide, nitroxyl anions, and nitrergic transmitter by 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole in the rat anococcygeus muscle.
Topics: Animals; Electric Stimulation; Indazoles; Male; Muscle Relaxation; Muscle, Skeletal; Neurotransmitte | 2005 |
Altered vascular reactivity in mice made hypertensive by nitric oxide synthase inhibition.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascul | 2005 |
Relaxant effects of the soluble guanylate cyclase activator and NO sensitizer YC-1 in piglet pulmonary arteries.
Topics: Animals; Animals, Newborn; Enzyme Activators; Guanylate Cyclase-Activating Proteins; Indazoles; Musc | 2006 |
Comparative relaxant effects of YC-1 and DEA/NO on the sheep sphincter of Oddi.
Topics: Animals; Cyclic GMP; Hydrazines; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Neuromuscu | 2006 |
Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators.
Topics: Animals; Cells, Cultured; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Ind | 1997 |
Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle.
Topics: Aldehyde Reductase; Animals; Carotid Arteries; Chalcone; Chalcones; Dose-Response Relationship, Drug | 1997 |
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vi | 1999 |
YC-1 potentiates nitric oxide-induced relaxation in guinea-pig trachea.
Topics: Animals; Cyclic AMP; Cyclic GMP; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indazoles; | 1999 |
Involvement of K(+) channels in the relaxant effects of YC-1 in vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Carotid Arteries; Dose-Response Relationship, Drug; Drug Interactions; Fem | 1999 |
Release of nitric oxide from endothelial cells stimulated by YC-1, an activator of soluble guanylyl cyclase.
Topics: Animals; Aorta, Thoracic; Bradykinin; Calcimycin; Cattle; Cells, Cultured; Cyclic GMP; Dose-Response | 1999 |
Potentiation of carbon monoxide-induced relaxation of rat aorta by YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole].
Topics: Animals; Aorta, Thoracic; Carbon Monoxide; Drug Synergism; Guanylate Cyclase; In Vitro Techniques; I | 2000 |
YC-1 enhances the responsiveness of tolerant vascular smooth muscle to glyceryl trinitrate.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; Enzyme Activators; In Vitro Techniques; Indazo | 2001 |
Carbon monoxide relaxes the female pig urethra as effectively as nitric oxide in the presence of YC-1.
Topics: Animals; Carbon Monoxide; Electric Stimulation; Enzyme Activators; Female; Indazoles; Muscle Relaxat | 2002 |