3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Muscle Contraction in 6 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Triguero, D | 1 |
| Sancho, M | 1 |
| García-Flores, M | 1 |
| García-Pascual, A | 1 |
| Hsieh, GC | 1 |
| O'Neill, AB | 1 |
| Moreland, RB | 1 |
| Sullivan, JP | 1 |
| Brioni, JD | 1 |
| Wegener, JW | 1 |
| Nawrath, H | 1 |
| Hebeiss, K | 1 |
| Kilbinger, H | 1 |
| Galle, J | 1 |
| Zabel, U | 1 |
| Hübner, U | 1 |
| Hatzelmann, A | 1 |
| Wagner, B | 1 |
| Wanner, C | 1 |
| Schmidt, HH | 1 |
| O'Reilly, DA | 1 |
| McLaughlin, BE | 1 |
| Marks, GS | 1 |
| Brien, JF | 1 |
| Nakatsu, K | 1 |
6 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Muscle Contraction
| Article | Year |
|---|---|
Presence of cyclic nucleotide-gated channels in the rat urethra and their involvement in nerve-mediated nitrergic relaxation.
Topics: Animals; Calcium Channel Blockers; Cyclic Nucleotide-Gated Cation Channels; Diltiazem; Enzyme Inhibi | 2009 |
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats.
Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhib | 2003 |
Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle.
Topics: Aldehyde Reductase; Animals; Carotid Arteries; Chalcone; Chalcones; Dose-Response Relationship, Drug | 1997 |
Nitric oxide-sensitive guanylyl cyclase inhibits acetylcholine release and excitatory motor transmission in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Depression, Chemical; Electric Stimulation; Enzyme Inhibitors; Female; Guany | 1998 |
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vi | 1999 |
YC-1 enhances the responsiveness of tolerant vascular smooth muscle to glyceryl trinitrate.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; Enzyme Activators; In Vitro Techniques; Indazo | 2001 |