3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Liver Neoplasms in 11 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hep3B hepatoma, NCI-H87 stomach carcinoma, Caki-1 renal carcinoma, SiHa cervical carcinoma, and SK-N-MC neuroblastoma cells were grown as xenografts in immunodeficient mice (69 mice total)." | 1.32 | YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. ( Cho, YS; Chun, YS; Kim, J; Kim, MS; Lee, JC; Park, JW; Yeo, EJ, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, W | 1 |
| Shi, X | 1 |
| Lu, S | 1 |
| Wu, L | 1 |
| Wang, Y | 1 |
| Kong, J | 3 |
| Kong, F | 1 |
| Gao, J | 1 |
| Zhang, Q | 1 |
| Dong, S | 2 |
| Gu, F | 1 |
| Ke, S | 2 |
| Pan, B | 2 |
| Shen, Q | 1 |
| Sun, H | 1 |
| Zheng, L | 2 |
| Sun, W | 1 |
| Wang, SX | 1 |
| Pei, ZZ | 1 |
| Wu, XH | 1 |
| Li, JK | 1 |
| Yang, YJ | 1 |
| Jiao, M | 1 |
| Nan, KJ | 1 |
| Li, X | 1 |
| Zhou, A | 1 |
| Sun, WB | 1 |
| Yeo, EJ | 2 |
| Chun, YS | 3 |
| Cho, YS | 2 |
| Kim, J | 2 |
| Lee, JC | 1 |
| Kim, MS | 2 |
| Park, JW | 3 |
| Wang, SW | 1 |
| Pan, SL | 1 |
| Guh, JH | 1 |
| Chen, HL | 1 |
| Huang, DM | 1 |
| Chang, YL | 1 |
| Kuo, SC | 1 |
| Lee, FY | 1 |
| Teng, CM | 1 |
| Ryu, JH | 1 |
| Jang, IJ | 1 |
| Cho, H | 1 |
| Lau, CK | 2 |
| Yang, ZF | 2 |
| Lam, CT | 2 |
| Tam, KH | 2 |
| Poon, RT | 2 |
| Fan, ST | 2 |
| Shin, DH | 1 |
| Kim, JH | 1 |
| Jung, YJ | 1 |
| Kim, KE | 1 |
| Jeong, JM | 1 |
| Lam, SP | 1 |
| Ngai, P | 1 |
11 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Liver Neoplasms
| Article | Year |
|---|---|
Hypoxia-induced overexpression of DEC1 is regulated by HIF-1α in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Regulation, Neopl | 2013 |
YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, He | 2014 |
[Effect of YC-1 on HIF-1 alpha and VEGF expression in human hepatocarcinoma cell lines].
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Gene Expression Regulation, Neoplastic | 2009 |
Activation of PI3 kinase/Akt/HIF-1α pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell | 2012 |
Insufficient radiofrequency ablation promotes angiogenesis of residual hepatocellular carcinoma via HIF-1α/VEGFA.
Topics: Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Carcinoma, Hepatocellular; Catheter Ablatio | 2012 |
YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Hepatocellular; Cell | 2003 |
YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Proliferation; Cyclic GM | 2005 |
YC-1 induces S cell cycle arrest and apoptosis by activating checkpoint kinases.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Line, Tumor; Checkpoint Kinase 1; | 2006 |
Suppression of hypoxia inducible factor-1alpha (HIF-1alpha) by YC-1 is dependent on murine double minute 2 (Mdm2).
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Down-Regulation; H | 2006 |
Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Drug S | 2007 |
Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Caspase 9; Cell | 2007 |