3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Hypoxia in 14 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 9 (64.29) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Uno, M | 1 |
| Ban, HS | 1 |
| Nakamura, H | 1 |
| Harada, T | 1 |
| Hirose, K | 1 |
| Wada, Y | 1 |
| Sato, M | 1 |
| Ichise, K | 1 |
| Aoki, M | 1 |
| Kato, T | 1 |
| Takeda, K | 1 |
| Takai, Y | 1 |
| Hsieh, KY | 1 |
| Wei, CK | 1 |
| Wu, CC | 1 |
| Wu, J | 1 |
| Ke, X | 1 |
| Fu, W | 1 |
| Gao, X | 1 |
| Zhang, H | 1 |
| Wang, W | 1 |
| Ma, N | 1 |
| Zhao, M | 1 |
| Hao, X | 1 |
| Zhang, Z | 1 |
| Zhuo, Y | 1 |
| Yuan, T | 1 |
| Duan, D | 1 |
| Wang, L | 1 |
| Ge, L | 1 |
| Wu, P | 1 |
| Wang, H | 1 |
| Lu, M | 1 |
| Kimura, K | 1 |
| Iwano, M | 1 |
| Higgins, DF | 1 |
| Yamaguchi, Y | 1 |
| Nakatani, K | 1 |
| Harada, K | 1 |
| Kubo, A | 1 |
| Akai, Y | 1 |
| Rankin, EB | 1 |
| Neilson, EG | 1 |
| Haase, VH | 1 |
| Saito, Y | 1 |
| Liu, L | 1 |
| Yu, Q | 1 |
| Lin, J | 1 |
| Lai, X | 1 |
| Cao, W | 1 |
| Du, K | 1 |
| Wang, Y | 1 |
| Wu, K | 1 |
| Hu, Y | 1 |
| Zhang, L | 1 |
| Xiao, H | 1 |
| Duan, Y | 1 |
| Huang, H | 1 |
| Yuan, G | 1 |
| Khan, SA | 1 |
| Luo, W | 1 |
| Nanduri, J | 1 |
| Semenza, GL | 1 |
| Prabhakar, NR | 1 |
| Huh, JW | 1 |
| Kim, SY | 1 |
| Lee, JH | 1 |
| Lee, YS | 1 |
| Zampell, JC | 1 |
| Yan, A | 1 |
| Avraham, T | 1 |
| Daluvoy, S | 1 |
| Weitman, ES | 1 |
| Mehrara, BJ | 1 |
| Deniro, M | 1 |
| Al-Mohanna, FA | 1 |
| Harrison, H | 1 |
| Rogerson, L | 1 |
| Gregson, HJ | 1 |
| Brennan, KR | 1 |
| Clarke, RB | 1 |
| Landberg, G | 1 |
| Yeo, EJ | 1 |
| Chun, YS | 1 |
| Park, JW | 1 |
| Funasaka, T | 1 |
| Yanagawa, T | 1 |
| Hogan, V | 1 |
| Raz, A | 1 |
1 review available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Hypoxia
| Article | Year |
|---|---|
New anticancer strategies targeting HIF-1.
Topics: Adaptation, Physiological; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; DNA-Bind | 2004 |
13 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Hypoxia
| Article | Year |
|---|---|
1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1alpha inhibitors.
Topics: Cell Line; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitory Concen | 2009 |
YC-1 sensitizes the antitumor effects of boron neutron capture therapy in hypoxic tumor cells.
Topics: Antineoplastic Agents; Boron Neutron Capture Therapy; Cell Hypoxia; Cell Line, Tumor; Cell Survival; | 2020 |
YC-1 Prevents Tumor-Associated Tissue Factor Expression and Procoagulant Activity in Hypoxic Conditions by Inhibiting p38/NF-κB Signaling Pathway.
Topics: Blood Coagulation; Blood Platelets; Cell Line, Tumor; Cyclic Nucleotide-Regulated Protein Kinases; G | 2019 |
Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.
Topics: Angiogenesis Inhibitors; Animals; Cell Hypoxia; Cell Line; Cobalt; Diabetic Retinopathy; Disease Mod | 2016 |
[Hypoxic condition promotes olfactory mucosa mesenchymal stem cells to differentiate into neurons and
underlying mechanisms].
Topics: Blotting, Western; Cell Differentiation; Cells, Cultured; Culture Media, Conditioned; Flow Cytometry | 2016 |
Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.
Topics: Aging; Animals; Disease Models, Animal; Enzyme Activators; Epithelial Cells; Female; Fibrosis; Gene | 2008 |
Hypoxia-inducible factor-1α is essential for hypoxia-induced mesenchymal stem cell mobilization into the peripheral blood.
Topics: Animals; Blood Cells; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cell Movement; Cells, Cu | 2011 |
Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia.
Topics: Animals; Carotid Body; Central Nervous System; Deferoxamine; Digoxin; Enzyme Inhibitors; Fibroblasts | 2011 |
YC-1 attenuates hypoxia-induced pulmonary arterial hypertension in mice.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Endothelin-1; E | 2011 |
HIF-1α coordinates lymphangiogenesis during wound healing and in response to inflammation.
Topics: Animals; Blotting, Western; CD4 Antigens; Cell Hypoxia; Edema; Female; Gene Expression; Hypoxia; Hyp | 2012 |
Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy.
Topics: Animals; Cation Transport Proteins; Cell Line; Enzyme Activators; Gene Expression Regulation; Hypoxi | 2012 |
Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status.
Topics: Animals; Blotting, Western; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Estrogen Antagonists; | 2013 |
Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia.
Topics: Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Neoplastic; Glucose-6-Phosphate Isomera | 2005 |