3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Hypertension in 4 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypertension was induced in four additional groups of WKY rats by 3 weeks of oral treatment with L-NAME." | 1.31 | Acute blood pressure effects of YC-1-induced activation of soluble guanylyl cyclase in normotensive and hypertensive rats. ( Friebe, A; Koesling, D; Kreutz, R; Paul, M; Rothermund, L, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mónica, FZ | 1 |
| Antunes, E | 1 |
| Ndisang, JF | 1 |
| Zhao, W | 1 |
| Wang, R | 1 |
| Linder, AE | 1 |
| Weber, DS | 1 |
| Whitesall, SE | 1 |
| D'Alecy, LG | 1 |
| Webb, RC | 1 |
| Rothermund, L | 1 |
| Friebe, A | 1 |
| Paul, M | 1 |
| Koesling, D | 1 |
| Kreutz, R | 1 |
1 review available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Hypertension
| Article | Year |
|---|---|
Stimulators and activators of soluble guanylate cyclase for urogenital disorders.
Topics: Aging; Animals; Benzoates; Diabetes Complications; Enzyme Activators; Humans; Hypertension; Indazole | 2018 |
3 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Hypertension
| Article | Year |
|---|---|
Selective regulation of blood pressure by heme oxygenase-1 in hypertension.
Topics: Animals; Blood Pressure; Culture Techniques; Cyclic GMP; Guanylate Cyclase; Heme Oxygenase (Decycliz | 2002 |
Altered vascular reactivity in mice made hypertensive by nitric oxide synthase inhibition.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascul | 2005 |
Acute blood pressure effects of YC-1-induced activation of soluble guanylyl cyclase in normotensive and hypertensive rats.
Topics: Animals; Blood Pressure; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; | 2000 |